Polyethyleneimine Capped Silver Nanoclusters as Efficient Antibacterial Agents

Xu, Dong; Wang, Qingyun; Yang, Tao; Cao, Jian; Lin, Qinlu; Yuan, Zhiqin; Li, Le

doi:10.3390/ijerph13030334

Cited by 37 publications

(21 citation statements)

References 38 publications

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“…[83,84] However, as with chemo drugs, the toxicity effect of AgNPs can be used as a strategy against cancer cells and tumors. [86][87][88][89][90] Eventually, with these fundamental understandings of structural-antibacterial activities, we believe more potent AgNPs can be developed by precise control of their size, shape, and surface chemistry, which are expected to achieve with recent breakthroughs in the precision nanochemistry. These Ag nanomaterials possess an ultrasmall hydrodynamic diameter (HD) (below 5.5 nm, kidney filtration threshold) and thus can be rapidly cleared out of body in a reasonable time period through the urinary system, which can significantly reduce the risk of long-term cytotoxicity.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Silver Nanoparticles: Structural Effects

Tang

Zheng

2018

Adv Healthcare Materials

749

432

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The increase of antibiotic resistance in bacteria has become a major concern for successful diagnosis and treatment of infectious diseases. Over the past few decades, significant progress has been achieved on the development of nanotechnology-based medicines for combating multidrug resistance in microorganisms. Among this, silver nanoparticles (AgNPs) hold great promise in addressing this challenge due to their broad-spectrum and robust antimicrobial properties. This review illustrates the antibacterial mechanisms of silver nanoparticles and further elucidates how different structural factors including surface chemistry, size, and shape, impact their antibacterial activities, which are expected to promote the future development of more potent silver nanoparticle-based antibacterial agents.

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Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Silver Nanoparticles: Structural Effects

Tang

Zheng

2018

Adv Healthcare Materials

749

432

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“…Silver has been extensively applied in daily life, and is well known for its antibacterial effect since antiquity [21]. Ultrasmall-sized silver nanoparticles (SNPs) generated through silver-ion reduction have enormous potential towards inhibiting the growth of a broad range of bacteria along with impeding the acquired multidrug resistance (MDR) [22][23][24][25][26]. These positively-charged ultrasmall nanoparticles can attach specifically to the bacterial surface through electrostatic interactions and internalize through damaging the cell wall.…”

Section: Introductionmentioning

confidence: 99%

Combating Antibiotic Resistance through the Synergistic Effects of Mesoporous Silica-Based Hierarchical Nanocomposites

2020

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The enormous influence of bacterial resistance to antibiotics has led researchers toward the development of various advanced antibacterial modalities. In this vein, nanotechnology-based devices have garnered interest owing to their excellent morphological as well as physicochemical features, resulting in augmented therapeutic efficacy. Herein, to overcome the multidrug resistance (MDR) in bacteria, we demonstrate the fabrication of a versatile design based on the copper-doped mesoporous silica nanoparticles (Cu-MSNs). Indeed, the impregnated Cu species in the siliceous frameworks of MSNs establish pH-responsive coordination interactions with the guest molecules, tetracycline (TET), which not only enhance their loading efficiency but also assist in their release in the acidic environment precisely. Subsequently, the ultrasmall silver nanoparticles-stabilized polyethyleneimine (PEI-SNP) layer is coated over Cu-MSNs. The released silver ions from the surface-deposited SNPs are capable of sensitizing the resistant strains through establishing the interactions with the biomembranes, and facilitate the generation of toxic free radicals, damaging the bacterial components. In addition to SNPs, Cu species impregnated in MSN frameworks synergistically act through the production of free radicals by participating in the Fenton-like reaction. Various physical characterization techniques for confirming the synthesis and successful surface modification of functional nanomaterials, as well as different antibacterial tests performed against MDR bacterial strains, are highly commendable. Remarkably, this versatile formulation has shown no significant toxic effects on normal mammalian fibroblast cells accounting for its high biocompatibility. Together, these biocompatible MSN-based trio-hybrids with synergistic efficacy and pH-responsive delivery of antibiotics potentially allow for efficient combat against MDR in bacteria.

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“…6,7 Specifically, NS has a broad-spectrum antimicrobial activity and highly killing efficacy by destroying the bacterial DNA and membrane, as well as inhibiting respiratory enzyme activity. 8 More importantly, few studies have reported that bacteria were resistant to NS, so NS is a promising candidate to replace antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Optimization and integration of nanosilver on polycaprolactone nanofibrous mesh for bacterial inhibition and wound healing in vitro and in vivo

Liu¹,

Luo²,

Wang³

et al. 2017

IJN

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Bacterial infection is a major hurdle to wound healing, and the overuse of antibiotics have led to global issue, such as emergence of multidrug-resistant bacteria, even “super bacteria”. On the contrary, nanosilver (NS) can kill bacteria without causing resistant bacterial strains. In this study, NS was simply generated in situ on the polycaprolactone (PCL) nanofibrous mesh using an environmentally benign and mussel-inspired dopamine (DA). Scanning electron microscopy showed that NS uniformly formed on the nanofibers of PCL mesh. Fourier transform infrared spectroscopy revealed the step-by-step preparation of pristine PCL mesh, including DA coating and NS formation, which were further verified by water contact angle changing from hydrophobic to hydrophilic. To optimize the NS dose, the antibacterial activity of PCL/NS against Staphylococcus aureus , Escherichia coli and Acinetobacter baumannii was detected by bacterial suspension assay, and the cytotoxicity of NS was evaluated using cellular morphology observation and Cell Counting Kit-8 (CCK8) assay. Then, inductively coupled plasma atomic emission spectrometry exhibited that the optimized PCL/NS had a safe and sustained silver release. Moreover, PCL/NS could effectively inhibit bacterial infection in an infectious murine full-thickness skin wound model. As demonstrated by the enhanced level of proliferating cell nuclear antigen (PCNA) in keratinocytes and longer length of neo-formed epidermis, PCL/NS accelerated wound healing by promoting re-epithelialization via enhancing keratinocyte proliferation in infectious wounds.

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Polyethyleneimine Capped Silver Nanoclusters as Efficient Antibacterial Agents

Cited by 37 publications

References 38 publications

Antibacterial Activity of Silver Nanoparticles: Structural Effects

Antibacterial Activity of Silver Nanoparticles: Structural Effects

Combating Antibiotic Resistance through the Synergistic Effects of Mesoporous Silica-Based Hierarchical Nanocomposites

Optimization and integration of nanosilver on polycaprolactone nanofibrous mesh for bacterial inhibition and wound healing in vitro and in vivo

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