Polyethyleneglycol diacrylate hydrogels with plasmonic gold nanospheres incorporated via functional group optimization

Abstract

We present a facile method for the preparation of polyethyleneglycol diacrylate (PEG-DA) hydrogels with plasmonic gold (Au) nanospheres incorporated for various biological and chemical sensing applications. Plasmonic Au nanospheres were prepared ex situ using the standard citrate reduction method with an average diameter of 3.5 nm and a standard deviation of 0.5 nm, and evaluated for their surface functionalization process intended for uniform dispersion in polymer matrices. UV-Visible spectroscopy reveals the existence of plasmonic properties for pristine Au nanospheres, functionalized Au nanospheres, and PEG-DA with uniformly dispersed functionalized Au nanospheres (hybrid Au/PEG-DA hydrogels). Hybrid Au/PEG-DA hydrogels examined by using Fourier transform infra-red spectroscopy (FT-IR) exhibit the characteristic bands at 1635, 1732 and 2882 cm −1 corresponding to reaction products of OH − originating from oxidized product of citrate, -C=O stretching from ester bond, and C-H stretching of PEG-DA, respectively. Thermal studies of hybrid Au/PEG-DA hydrogels show three-stage decomposition with their stabilities up to 500 °C. Optical properties and thermal stabilities associated with the uniform dispersion of Au nanospheres within hydrogels reported herein will facilitate various biological and chemical sensing applications.

An Ingestible Self-Polymerizing System for Targeted Sampling of Gut Microbiota and Biomarkers

“…The band at 1635 cm –1 can be attributed to a reaction product of OH – and oxidized products of ascorbate produced during the Fe 3+ reduction. , A similar observation was also made by Lee et al . for reducing PEGDA hydrogel formation in the presence of citric acid and Au 3+ reduction . Polymer chain extension was further confirmed with the shifting of a carbonyl band (1730 cm –1 ) of the acrylate group (Figure B inset).…”

“…24,25 A similar observation was also made by Lee et al for reducing PEGDA hydrogel formation in the presence of citric acid and Au 3+ reduction. 26 Polymer chain extension was further confirmed with the shifting of a carbonyl band (1730 cm −1 ) of the acrylate group (Figure 2B inset). Finally, characteristic hydrogel swelling (OH peak) was confirmed at 3360 cm −1 region, growing gradually over a period of time (ca.…”

Biosynthesis and Characteristics of Polyhydroxyalkanoates. 1. Polyhydroxybutyrates of Azotobacter vinelandii N-15

“…Various polyethylene glycol (PEG) macromonomers have been reported in the scientific literature for many years. These PEG macromonomers were prepared from block copolymers between PEG and biodegradable polyesters [5] or by acrylation and methacrylation of PEG [6][7][8][9]. One of the main advantages of using PEG macromonomers is the preparation of biomaterials hydrogel.…”

Study on the preparation and drug release property of Modified PEG-DA based hydrogels

“…Polyethylene glycol diacrylate is nonvolatile, non-toxic, environmentally friendly, and also tailor-made into various shapes. Polyethylene glycol diacrylate acts as potential stabilizers and matrices for the formation of functional hydrogels (7)(8)(9)(10).…”