“…Oxidative degradation also increases surface wear and osteolysis [7]. It is important to differentiate the delamination wear mechanisms, which produce fatigue failure [6,19], from the surface wear mechanisms, which produce submicron-and nanometer-sized wear particles and result in long-term osteolysis [16,17,24]. Surface wear leading to the potential of osteolysis is considered the longer-term risk factor, particularly since increased kinematics with more active patients substantially increases wear rates and the total wear volume in fixed-bearing knees [4,22].…”