Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting

Cole, Adam; David, Allan E.; Wang, Jianxin; Galbán, Craig J.; Hill, Hannah; Yang, Victor C.

doi:10.1016/j.biomaterials.2010.11.040

Cited by 275 publications

(184 citation statements)

References 36 publications

(65 reference statements)

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“…20,41 Polyethylene glycol-modified, cross-linked, and starchcoated iron oxide nanoparticles have been found to enhance magnetic tumor targeting. 92 Because surface modification or coating can sometimes significantly reduce the superparamagnetic properties of SPIONs, a novel approach of delivering drug-loaded SPIONs by encapsulating them within submit your manuscript | www.dovepress.com…”

Section: Role In Cancer Therapymentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Wahajuddin¹,

Arora²

2012

IJN

866

574

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Section: Role In Cancer Therapymentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Wahajuddin¹,

Arora²

2012

IJN

866

574

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“…Various polyethylene glycol (PEG)-coated nano-formulations have shown prolonged circulation time in vivo. [16][17][18][19] On the other hand, the enhancement of drug retention in long circulating NPs increases drug uptake and accumulation in the tumor tissue. To study the retention of drugs in the NPs, many in vitro release studies have been conducted in aqueous buffers (eg, phosphate buffered saline [PBS]) and are expected to predict the in vivo retention behaviors of the nano-formulation.…”

Section: Introductionmentioning

confidence: 99%

Development and optimization of oil-filled lipid nanoparticles containing docetaxel conjugates designed to control the drug release rate in vitro and in vivo

Feng¹,

Wu²,

Ma³

et al. 2011

IJN

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Three docetaxel (DX) lipid conjugates: 2′-lauroyl-docetaxel (C12-DX), 2′-stearoyl-docetaxel (C18-DX), and 2′-behenoyl-docetaxel (C22-DX) were synthesized to enhance drug loading, entrapment, and retention in liquid oil-filled lipid nanoparticles (NPs). The three conjugates showed ten-fold higher solubility in the liquid oil phase Miglyol 808 than DX. To further increase the drug entrapment efficiency in NPs, orthogonal design was performed. The optimized formulation was composed of Miglyol 808, Brij 78, and Vitamin E tocopheryl polyethylene glycol succinate (TPGS). The conjugates were successfully entrapped in the reduced-surfactant NPs with entrapment efficiencies of about 50%–60% as measured by gel permeation chromatography (GPC) at a final concentration of 0.5 mg/mL. All three conjugates showed 45% initial burst release in 100% mouse plasma. Whereas C12-DX showed another 40% release over the next 8 hours, C18-DX and C22-DX in NPs showed no additional release after the initial burst of drug. All conjugates showed significantly lower cytotoxicity than DX in human DU-145 prostate cancer cells. The half maximal inhibitory concentration values (IC 50 ) of free conjugates and conjugate NPs were comparable except for C22-DX, which was nontoxic in the tested concentration range and showed only vehicle toxicity when entrapped in NPs. In vivo, the total area under the curve (AUC 0–∞ ) values of all DX conjugate NPs were significantly greater than that of Taxotere, demonstrating prolonged retention of drug in the blood. The AUC 0–∞ value of DX in Taxotere was 8.3-fold, 358.0-fold, and 454.5-fold lower than that of NP-formulated C12-DX, C18-DX, and C22-DX, respectively. The results of these studies strongly support the idea that the physical/chemical properties of DX conjugates may be fine-tuned to influence the affinity and retention of DX in oil-filled lipid NPs, which leads to very different pharmacokinetic profiles and blood exposure of an otherwise potent chemo-therapeutic agent. These studies and methodologies may allow for improved and more potent nanoparticle-based formulations.

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“…6,7 Several studies have indicated that the particle biodistribution is dependent on the sizes and surface properties of the particles. 3,[8][9][10] However, in many cases the conclusion was made using SPIOs, which differ in more than one parameter, making it difficult to differentiate the influence of an individual parameter. We also believe that it is important to compare a set of three or more SPIOs in order to draw a consistent picture.…”

mentioning

confidence: 99%

Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles

Roohi

Lohrke²,

Ide³

et al. 2012

IJN

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Purpose: Magnetic resonance imaging (MRI), one of the most powerful imaging techniques available, usually requires the use of an on-demand designed contrast agent to fully exploit its potential. The blood kinetics of the contrast agent represent an important factor that needs to be considered depending on the objective of the medical examination. For particulate contrast agents, such as superparamagnetic iron oxide nanoparticles (SPIOs), the key parameters are particle size and characteristics of the coating material. In this study we analyzed the effect of these two properties independently and systematically on the magnetic behavior and blood half-life of SPIOs. Methods: Eleven different SPIOs were synthesized for this study. In the first set (a), seven carboxydextran (CDX)-coated SPIOs of different sizes (19-86 nm) were obtained by fractionating a broadly size-distributed CDX-SPIO. The second set (b) contained three SPIOs of identical size (50 nm) that were stabilized with different coating materials, polyacrylic acid (PAA), polyethylene glycol, and starch. Furthermore, small PAA-SPIOs (20 nm) were synthesized to gain a global insight into the effects of particle size vs coating characteristics. Saturation magnetization and proton relaxivity were determined to represent the magnetic and imaging properties. The blood half-life was analyzed in rats using MRI, time-domain nuclear magnetic resonance, and inductively coupled plasma optical emission spectrometry. Results: By changing the particle size without modifying any other parameters, the relaxivity r 2 increased with increasing mean particle diameter. However, the blood half-life was shorter for larger particles. The effect of the coating material on magnetic properties was less pronounced, but it had a strong influence on blood kinetics depending on the ionic character of the coating material. Conclusion:In this report we systematically demonstrated that both particle size and coating material influence blood kinetics and magnetic properties of SPIO independently. These data provide key information for the selection of a contrast agent for a defined application and are additionally valuable for other nano areas, such as hyperthermia, drug delivery, and nanotoxicology.

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Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting

Cited by 275 publications

References 36 publications

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Development and optimization of oil-filled lipid nanoparticles containing docetaxel conjugates designed to control the drug release rate in vitro and in vivo

Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles

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