Polyethylene Glycol–Based Nanocerium Improves Healing Responses in Excisional and Incisional Wound Models in Rats

Kardan, Tara; Mohammadi, Rahim; Taghavifar, Saeed; Cheraghi, Marzieh; Yahoo, Ashkan; Mohammadnejad, Kianoush

doi:10.1177/1534734620912102

Cited by 9 publications

(10 citation statements)

References 28 publications

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“…INFCTD-HMLT-CNM animals showed significantly higher new vessel formation in comparison with INFCTD-CNM and INFCTD-HAMLET groups. Enhanced new vessel formation after wound creation indicated that cinnamon nanoparticles as well as HAMLET could promote the healing process due to enhancement in cellular infiltration [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…We followed the methods of others for biochemical investigations [ 16 , 17 ]. To do this, we took the specimens of wound tissue and assessed their enzyme activities.…”

Section: Methodsmentioning

confidence: 99%

“…Image analyzing software (Image-Pro Express, version 6.0.0.319, Media Cybernetics) was adopted to score morphological results. Using a five-step scoring system, the histological parameters were classified based on the intensity of occurrence (−, absence; +, discrete; ++, moderate; +++, intense; and ++++, very intense) [ 16 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…We followed the methods of others to measure contents of hydroxyproline in the tissue [ 17 ]. To dry the harvested tissues to constant weight, a hot air oven at 60 to 70°C was used.…”

Section: Methodsmentioning

confidence: 99%

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Accelerative Effect of Cinnamon Nanoparticles as well as HAMLET on Healing of Wounds Infected with MRSA in Diabetic Rats

Ali

Najafpour

Farahpour

et al. 2021

BioMed Research International

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Objective. The aim of the present study was to investigate the effect of cinnamon nanoparticles (CNPs) on healing of wounds infected with methicillin-resistant Staphylococcus aurous with human alpha-lactalbumin made lethal to tumor cells sensitization in diabetic rats. Methods. We included fifty diabetic male rats and divided them into 5 groups. There were 10 rats in each group as follows: CONTROL group: we did not infect the CONTROL group. The wound was only covered with sterile saline 0.9% solution (0.1 mL). INFCTD group: in this group, the wounds were infected with MRSA and covered with sterile saline 0.9% solution (0.1 mL). INFCTD-HMLT group: in this group, the wounds were infected with MRSA and HAMLET (100 μg). INFCTD-CNM group: in this group, the wounds were infected with MRSA and 0.1 mL CNPs (1 mg/mL) were applied topically to wounds. INFCTD-HMLT-CNM group: in this group, the wounds were infected with MRSA, HAMLET (100 μg), and 0.1 mL CNPs (1 mg/mL). Results. Bacteriology, wound area reduction measurements, biochemistry, histomorphometrical studies, hydroxyproline levels, and reverse transcription polymerase chain reaction for caspase-3, Bcl-2, and p53 showed significant difference between rats in the INFCTD-HMT-CNM group in comparison with other groups ( P < 0.05 ). Conclusions. Accelerated healing of diabetic wounds infected with MRSA showed that local application of cinnamon nanoparticles along with HAMLET sensitization on S. aureus-infected wound could be taken into consideration.

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Section: Discussionmentioning

confidence: 99%

“…We followed the methods of others for biochemical investigations [ 16 , 17 ]. To do this, we took the specimens of wound tissue and assessed their enzyme activities.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…We followed the methods of others to measure contents of hydroxyproline in the tissue [ 17 ]. To dry the harvested tissues to constant weight, a hot air oven at 60 to 70°C was used.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Accelerative Effect of Cinnamon Nanoparticles as well as HAMLET on Healing of Wounds Infected with MRSA in Diabetic Rats

Ali

Najafpour

Farahpour

et al. 2021

BioMed Research International

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“…In rats, Kardan et al 15 have demonstrated that polyethylene glycol-based nanocerium facilitates healing in excisional and incisional wounds. Again in rats, Javanmardi et al 16 have examined the effect of Gundelia tournefortii L extract and milk cream on burns.…”

mentioning

confidence: 99%

Autumn Issue: Praise of Mighty Harmonies

Παπάνας

Papi²

2021

The International Journal of Lower Extremity Wounds

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Efficacy of co-loading Ag nanoparticles and metronidazole in PEG–gelatin-based sponges for the treatment of chronic wounds

Alven,

Adeyemi,

Ubanako

et al. 2023

Polym. Bull.

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Polymer-based sponges loaded with antibacterial agents are potential wound dressings ideal for treating bacteria-infected wounds. Gelatin/poly (ethylene glycol) (PEG) sponge-based wound dressings loaded with metronidazole and Ag nanoparticles with different degrees of cross-linking were prepared, and their capability to treat infected wounds in vitro was evaluated. The degree of cross-linking of the sponges varied, and the porosity of the sponges was in the range of 15.64–91.10%. The amount of gelatin used to prepare the sponges influenced the porosity of the sponges. The sponges displayed an initial burst drug release of metronidazole followed by a sustained release profile. The sponges exhibited considerable antibacterial activity against Gram-positive and Gram-negative bacteria. The % cell viability of the sponges was in the range of 71.17–86.10%, indicating distinguished biocompatibility. The in vitro experiment showed that the sponge loaded with metronidazole, SAM2%, displayed a significant reduction of 66.68% in the scratch area compared to the sponge loaded with a combination of silver nanoparticles and metronidazole with a closure rate of 46.61% at 96 h. The promising features of the sponges indicate that they are potential wound dressings for treating infected wounds.

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Polyethylene Glycol–Based Nanocerium Improves Healing Responses in Excisional and Incisional Wound Models in Rats

Cited by 9 publications

References 28 publications

Accelerative Effect of Cinnamon Nanoparticles as well as HAMLET on Healing of Wounds Infected with MRSA in Diabetic Rats

Accelerative Effect of Cinnamon Nanoparticles as well as HAMLET on Healing of Wounds Infected with MRSA in Diabetic Rats

Autumn Issue: Praise of Mighty Harmonies

Efficacy of co-loading Ag nanoparticles and metronidazole in PEG–gelatin-based sponges for the treatment of chronic wounds

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