Polyetheretherketone/poly (glycolic acid) blend scaffolds with biodegradable properties

Shuai, Chenying; Wu, Ping; Zhong, Yan; Feng, Pei; Gao, Chengde; Huang, Wei; Zhou, Zhiyang; Chen, Li; Shuai, Cijun

doi:10.1080/09205063.2016.1210420

Cited by 30 publications

(23 citation statements)

References 42 publications

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“…For more than 5 years, the patient was monitored and during this period, no complications were observed (Scolozzi 2012). Thus, PEEK is a biocompatible polymer that meets the functional requirement for implant materials is useful for bone scaffolding, and does not degrade at normal conditions (Shuai et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Mechanical properties of highly porous PEEK bionanocomposites incorporated with carbon and hydroxyapatite nanoparticles for scaffold applications

2019

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Bone regeneration is of great importance worldwide, because of various bone diseases, such as infections, tumors, and resultant fracture, birth defects, and bone loss due to trauma, explosion, or accident. Bone regeneration can be achieved by several materials and templates manufactured through various fabrication techniques. Uses of different materials and scaffold fabrication techniques have been explored over the past 20 years. In this research, polyetheretherketone (PEEK) was used to fabricate highly porous bionanocomposite foams for bone scaffolding. Melt casting and salt porogen (200–500 µm size) leaching methods were adapted to create an adequate pore size and the necessary percent of porosity, because pore size plays a vital role in cell implantation and growth. Porosity (75% and 85%) of the prepared scaffolds was adjusted by changing salt concentrations in the PEEK powder. Hydroxyapatite (HA) and carbon particles were used to improve cell attachments and interactions with the porous PEEK and to increase the mechanical properties of the scaffold materials. Carbon fiber (CF) and carbon nanotubes (CNTs) were uniformly dispersed into the PEEK powder before melt casting to enhance the mechanical properties and to observe the influence of the carbon particles on the properties of PEEK bionanocomposite foam. Compression test results of the fabricated bionanocomposites showed that HA and carbon particles are the potential filler materials for the enhancement of bionanocomposite mechanical properties. About 186% enhancement of compression modulus and 43% enhancement of yield strength were observed while incorporating only 0.5 wt% of CNTs into PEEK/HA bionanocomposites having 75% porosity, compared to PEEK/HA 20 wt% bionanocomposites. Micro-computed tomography (micro-CT) test results reveal that pore size and interconnectivity of the nanocomposite foams are in order and within the designed sizes. Mechanical tests proved that PEEK bionanocomposite foam has the potential for use in bone scaffolding and other biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Mechanical properties of highly porous PEEK bionanocomposites incorporated with carbon and hydroxyapatite nanoparticles for scaffold applications

2019

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“…Beyond the referred printed polymers, other components such as collagen [106] or MgO [115] have been added to promote bioactivity of the printed composites, while the incorporation of graphene nanoplatelets [116] and nanodiamonds [110] has been used to improve the mechanical properties of final scaffolds. In addition, surface properties [117] and degradation rate [118] of the matrix should also be taken into account in view of cell colonization. SLS still has some limitations, such as the shrinkage of scaffolds [119] but in the context of cellularized materials, the high melting temperatures [120] is the main limitation regarding cytocompatibility of the technique.…”

Section: (C) Three-dimensional Printingmentioning

confidence: 99%

Colonization versus encapsulation in cell-laden materials design: porosity and process biocompatibility determine cellularization pathways

Parisi

Qin

Fernandes

2021

Phil. Trans. R. Soc. A.

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Seeding materials with living cells has been—and still is—one of the most promising approaches to reproduce the complexity and the functionality of living matter. The strategies to associate living cells with materials are limited to cell encapsulation and colonization, however, the requirements for these two approaches have been seldom discussed systematically. Here we propose a simple two-dimensional map based on materials' pore size and the cytocompatibility of their fabrication process to draw, for the first time, a guide to building cellularized materials. We believe this approach may serve as a straightforward guideline to design new, more relevant materials, able to seize the complexity and the function of biological materials. This article is part of the theme issue ‘Bio-derived and bioinspired sustainable advanced materials for emerging technologies (part 1)’.

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“…PEEK is non-toxic [156] but biologically inert [155] with a long biodegradation time [162]. To control degradation rates, PEEK has been blended with other polymers such as PGA (percentage weight loss after 28 days of 10.57% for 20% PGA, 12.88% for 40% PGA, 8.64% without nano-TiO 2 , and 9.72% with nano-TiO 2 [163,164]) and poly-L-lactide (PLLA) (up to 14% weight loss over 28 days for 50 wt% PLLA [165]) although further studies on its degradation products and their bio-absorbability are required. SLS was used to fabricate scaffolds in both cases, with incorporated nano-TiO 2 particles for an anti-bacterial function and β-TCP particles for bioactivity and biodegradability, respectively.…”

Section: Biocompatibility Biodegradability and Bioactivitymentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at different scales. Moreover, it is now possible to tailor their biomechanical and topological properties while taking inspiration from the characteristics of the extracellular matrix, the three-dimensional scaffold in which cells proliferate, migrate, and differentiate. In such context, there is therefore a continuous quest for synthetic and nature-derived composite materials that must hold biocompatible, biodegradable, bioactive features and also be compatible with the envisioned fabrication strategy. The structure of the current review is intended to provide to both micro-engineers and cell biologists a comparative overview of the characteristics, advantages, and drawbacks of the major 3D printing techniques, the most promising biomaterials candidates, and the trade-offs that must be considered in order to replicate the properties of natural microenvironments.

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Polyetheretherketone/poly (glycolic acid) blend scaffolds with biodegradable properties

Cited by 30 publications

References 42 publications

Mechanical properties of highly porous PEEK bionanocomposites incorporated with carbon and hydroxyapatite nanoparticles for scaffold applications

Mechanical properties of highly porous PEEK bionanocomposites incorporated with carbon and hydroxyapatite nanoparticles for scaffold applications

Colonization versus encapsulation in cell-laden materials design: porosity and process biocompatibility determine cellularization pathways

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

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