Polyether-polyester block copolymers by non-catalysed polymerization of ɛ-caprolactone with poly(ethylene glycol)

Cerrai, P.; Tricoli, M.; Andruzzi, F.; Paci, Maurizio; Paci, Massimo

doi:10.1016/0032-3861(89)90126-2

Cited by 108 publications

(60 citation statements)

References 6 publications

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“…They obtained copolymers by anionic polymerization using naphthalene-sodium complex as catalyst. Later, catalyst-free polymerization was introduced to synthesize the PCL/PEG copolymer by Cerrai et al [98].…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

et al. 2011

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Self-assembling block copolymers (poloxamers, PEG/PLA and PEG/PLGA diblock and triblock copolymers, PEG/polycaprolactone, polyether modified poly(Acrylic Acid)) with large solubility difference between hydrophilic and hydrophobic moieties have the property of forming temperature dependent micellar aggregates and, after a further temperature increase, of gellifying due to micelle aggregation or packing. This property enables drugs to be mixed in the sol state at room temperature then the solution can be injected into a target tissue, forming a gel depot in-situ at body temperature with the goal of providing drug release control. The presence of micellar structures that give rise to thermoreversible gels, characterized by low toxicity and mucomimetic properties, makes this delivery system capable of solubilizing water-insoluble or poorly soluble drugs and of protecting labile molecules such as proteins and peptide drugs.

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Section: Synthesis and Characterizationmentioning

confidence: 99%

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

et al. 2011

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“…36 Therefore, the degradation properties of a polymer can be adjusted by changing the monomer composition. Several IR studies have been reported on different copolymers containing LA, GA, CL and -O-CH 2 -CH 2 -O-oxyethylene (OE) units: PLA-POE-PLA 38 -43 and PCL-POE-PCL 44,45 block copolymers, PCL-POE multiblock copolymers, 46 -47 PLAGA-PCL-PLAGA block copolymers, 48 PCL-POE-PLA three-component copolymers 49 and three-component copolymers derived from GA, LA and CL. 50 A Raman study on chain folding in PCL provided a strategy for blending PCL and POE in the crystalline state.…”

Section: Pcl-containing Block Copolymers: Vibrational Characterizatiomentioning

confidence: 99%

Vibrational spectroscopy of polymeric biomaterials

Taddei

Tinti

Fini

2001

J Raman Spectroscopy

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This review highlights the potential of vibrational spectroscopy for investigating the molecular structure of some polymeric materials used in biomedical applications in relation to their biocompatibility. Many types of polymers are used for biomedical purposes; depending on the application, bioresorbable or non-bioresorbable (semi-crystalline or amorphous) polymers are used. Among bioresorbable polymers, we focused on homopolymers and copolymers based on poly(lactic acid), poly(glycolic acid) and poly(ecaprolactone). Being a nondestructive technique, Raman spectroscopy proved particularly suitable for evaluating the molecular structure and crystallinity of bioresorbable polymers and their degradation products. For various biomedical applications, non-degradable semi-crystalline polymers have been widely employed; in this class of polymers, we concentrated on ultra-high molecular weight polyethylene (UHMWPE) used in orthopaedic implants (total hip and knee joints). Vibrational spectroscopy appeared particularly suitable in studying the oxidation and crystallinity of UHMWPE.

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“…When a crystallizable component is confined within a large number of small isolated microdomains, a substantial decrease in crystallinity as compared to the corresponding homopolymers can sometimes be observed as a result of larger supercooling that are required for crystallization as well as the topological restrictions caused by the confinement. The factors that affect the crystallization properties of PEO-b-PCL block copolymers have been reported and typically depend on the block length and the crystallization temperature [33][34][35]. Intuitively, the block with higher molecular weight crystallizes first in PEO-b-PCL crystalline-crystalline diblock copolymers whereas there are not any relevant reports on following the crystallization process of a symmetric diblock copolymer.…”

Section: Crystallization Transitions In Peo-b-pcl Diblock Copolymers mentioning

confidence: 99%

Crystallization Behaviors and Structure Transitions of Biocompatible and Biodegradable Diblock Copolymers

Xue

Jiang

2014

Polymers

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Biocompatible and biodegradable block copolymers (BBCPs) containing crystalline blocks become increasingly important in polymer science, and have great potential applications in polymer materials. Crystallization in polymers is accompanied by the adoption of an extended conformation, or often by chain folding. It is important to distinguish between crystallization in homopolymers and in block copolymers. In homopolymers, chain folding leads to metastable structures introduced by the crystallization kinetics. In contrast, equilibrium chain folding in diblocks can be achieved as the equilibrium number of the folds is controlled by the size of the second block. The structures of BBCPs, which are determined by the competition between crystallization, microphase separation, kinetics and processing, have a tremendous influence on the final properties and applications. In this review, we present the recent advances on crystalline-crystalline diblock copolymer in our group.

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Polyether-polyester block copolymers by non-catalysed polymerization of ɛ-caprolactone with poly(ethylene glycol)

Cited by 108 publications

References 6 publications

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

Vibrational spectroscopy of polymeric biomaterials

Crystallization Behaviors and Structure Transitions of Biocompatible and Biodegradable Diblock Copolymers

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