Polyelectrolyte multilayer surface functionalization of poly(dimethylsiloxane) (PDMS) for reduction of yeast cell adhesion in microfluidic devices

Schmolke, Hannah; Demming, Stefanie; Edlich, Astrid; Magdanz, Veronika; Büttgenbach, S.; Franco‐Lara, Ezequiel; Krull, Rainer; Klages, Claus‐Peter

doi:10.1063/1.3523059

Cited by 42 publications

(35 citation statements)

References 38 publications

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“…34 However, to the best of our knowledge, no study has explored the combination of PDMS microstructuration and PEM coating that provides a substrate for muscle differentiation over a long time period (typically a week) for muscle tissue engineering. The deposit of a (PLL/ The red line corresponds to the cross-section line.…”

Section: Filmsmentioning

confidence: 99%

Engineering Muscle Tissues on Microstructured Polyelectrolyte Multilayer Films

Monge

Ren

Berton

et al. 2012

Tissue Engineering Part A

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Section: Filmsmentioning

confidence: 99%

Engineering Muscle Tissues on Microstructured Polyelectrolyte Multilayer Films

Monge

Ren

Berton

et al. 2012

Tissue Engineering Part A

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“…Studies showed that PEMs based on the combination of PDADMAC/PAA and PAH/PAA already decrease the adhesion strength of the yeast Saccharomyces cerevisiae. However, a further reduction in initial cell attachment and adhesion strength can be observed after adsorption of PAA-g-PEG copolymer onto PEMs [42].…”

Section: Surface Hydrophobicitymentioning

confidence: 99%

Biofunctionalization of surfaces using polyelectrolyte multilayers

Hartmann¹,

Krastev²

2018

Nano Online

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Biomaterials play a central role in modern strategies in regenerative medicine and tissue engineering to restore the structure and function of damaged or dysfunctional tissue and to direct cellular behavior. Both biologically derived and synthetic materials have been extensively explored in this context. However, most materials when implanted into living tissue initiate a host response. Modern implant design therefore aims to improve implant integration while avoiding chronic inflammation and foreign body reactions, and thus loss of the intended implant function. Directing these processes requires an in-depth understanding of the immunological processes that take place at the interface between biomaterials and the host tissue. The physicochemical properties of biomaterial surfaces (charge, charge density, hydrophilicity, functional molecular domains, etc.) are decisive, as are their stiffness, roughness and topography. This review outlines specific strategies, using polyelectrolyte multilayers to modulate the interactions between biomaterial surfaces and biological systems. The described coatings have the potential to control the adhesion of proteins, bacteria and mammalian cells. They can be used to decrease the risk of bacterial infections occurring after implantation and to achieve better contact between biological tissue and implants. In summary, these results are important for further development and modification of surfaces from different medical implants.

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“…Studies showed that PEMs based on the combination of PDAD-MAC/PAA and PAH/PAA already decrease the adhesion strength of the yeast Saccharomyces cerevisiae. However, a further reduction in initial cell attachment and adhesion strength can be observed after adsorption of PAA-g-PEG copolymer onto PEMs [42].…”

Section: Correlation Between Surface Physicochemical Properties Of Pementioning

confidence: 99%

Biofunctionalization of surfaces using polyelectrolyte multilayers

Hartmann

Krastev

2017

BioNanoMaterials

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Abstract:Biomaterials play a central role in modern strategies in regenerative medicine and tissue engineering to restore the structure and function of damaged or dysfunctional tissue and to direct cellular behavior. Both biologically derived and synthetic materials have been extensively explored in this context. However, most materials when implanted into living tissue initiate a host response. Modern implant design therefore aims to improve implant integration while avoiding chronic inflammation and foreign body reactions, and thus loss of the intended implant function. Directing these processes requires an in-depth understanding of the immunological processes that take place at the interface between biomaterials and the host tissue. The physicochemical properties of biomaterial surfaces (charge, charge density, hydrophilicity, functional molecular domains, etc.) are decisive, as are their stiffness, roughness and topography. This review outlines specific strategies, using polyelectrolyte multilayers to modulate the interactions between biomaterial surfaces and biological systems. The described coatings have the potential to control the adhesion of proteins, bacteria and mammalian cells. They can be used to decrease the risk of bacterial infections occurring after implantation and to achieve better contact between biological tissue and implants. In summary, these results are important for further development and modification of surfaces from different medical implants.

show abstract

Polyelectrolyte multilayer surface functionalization of poly(dimethylsiloxane) (PDMS) for reduction of yeast cell adhesion in microfluidic devices

Cited by 42 publications

References 38 publications

Engineering Muscle Tissues on Microstructured Polyelectrolyte Multilayer Films

Engineering Muscle Tissues on Microstructured Polyelectrolyte Multilayer Films

Biofunctionalization of surfaces using polyelectrolyte multilayers

Biofunctionalization of surfaces using polyelectrolyte multilayers

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