Polyelectrolyte complexes based on alginate/tanfloc: Optimization, characterization and medical application

Facchi, Débora P.; Lima, Amanda Camerini; Oliveira, Jean Halison de; Lazarin-Bidóia, Danielle; Nakamura, Celso V.; Canesin, Edmilson Antônio; Bonafé, Elton Guntendorfer; Monteiro, Johny P.; Visentainer, Jesuí V.; Muniz, Edvani C.; Martins, Alessandro F.

doi:10.1016/j.ijbiomac.2017.05.033

Cited by 51 publications

(31 citation statements)

References 35 publications

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“…Moreover, these complexes are also of interest for many other applications, including the production of flexible electronic devices and electronic inks, as potential drug delivery systems and tissue regeneration scaffolds, or for the development of improved membrane separation technologies, among others (Zhao et al 2011;Marciel et al 2017;Facchi et al 2017;Zhao et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Self-assembled gelatin-ι-carrageenan encapsulation structures for intestinal-targeted release applications

Gómez‐Mascaraque

Llavata-Cabrero

Martínez‐Sanz

et al. 2018

Journal of Colloid and Interface Science

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In this work, natural biopolymeric encapsulation structures were developed through the self-assembly of gelatin and ι-carrageenan in aqueous solutions. The interactions of this binary system and of a ternary system containing a polyphenol-rich extract were deeply explored for the development of intestinal delivery systems. The processing of the structures (extrusion vs. freeze-drying) greatly influenced release properties, explained by the specific interactions between gelatin and polyphenols, thus allowing for tuning the processing conditions depending on the desired target application. Release was further controlled by incorporating a divalent salt, giving raise to extract-loaded ι-carrageenan/gelatin capsules with adequate release profiles for intestinal targeted delivery. These results demonstrate the potential of exploiting biopolymer interactions for designing bioactive delivery systems using environmentally friendly processes which do not involve the use of toxic or harsh solvents or cross-linkers.

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Section: Introductionmentioning

confidence: 99%

Self-assembled gelatin-ι-carrageenan encapsulation structures for intestinal-targeted release applications

Gómez‐Mascaraque

Llavata-Cabrero

Martínez‐Sanz

et al. 2018

Journal of Colloid and Interface Science

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“…Alginate is an anionic polysaccharide that is extracted mainly from brown seaweed [90]. Similar to unmodified starch, this material can be used also as a second flocculant to improve flocculation efficiency and reduce the dosage of the main chemical flocculant.…”

Section: Organic Flocculantmentioning

confidence: 99%

Flocculation Harvesting Techniques for Microalgae: A Review

et al. 2019

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Microalgae have been considered as one of the most promising biomass feedstocks for various industrial applications such as biofuels, animal/aquaculture feeds, food supplements, nutraceuticals, and pharmaceuticals. Several biotechnological challenges associated with algae cultivation, including the small size and negative surface charge of algal cells as well as the dilution of its cultures, need to be circumvented, which increases the cost and labor. Therefore, efficient biomass recovery or harvesting of diverse algal species represents a critical bottleneck for large-scale algal biorefinery process. Among different algae harvesting techniques (e.g., centrifugation, gravity sedimentation, screening, filtration, and air flotation), the flocculation-based processes have acquired much attention due to their promising efficiency and scalability. This review covers the basics and recent research trends of various flocculation techniques, such as auto-flocculation, bio-flocculation, chemical flocculation, particle-based flocculation, and electrochemical flocculation, and also discusses their advantages and disadvantages. The challenges and prospects for the development of eco-friendly and economical algae harvesting processes have also been outlined here.

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“…Recently, tanfloc (TA) has attracted considerable interest due to its promising cytocompatibility, biodegradability, and antimicrobial properties (Facchi et al, ). TA is a hydrophilic, cationic (pK a ≈ 6.0), and condensed amino‐functionalized tannin derivative (Martins et al, ).…”

Section: Introductionmentioning

confidence: 99%

Enhanced hemocompatibility and antibacterial activity on titania nanotubes with tanfloc/heparin polyelectrolyte multilayers

Sabino

Kauk

Madruga

et al. 2020

J Biomedical Materials Res

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Biomaterial-associated thrombus formation and bacterial infection remain major challenges for blood-contacting devices. For decades, titanium-based implants have been largely used for different medical applications. However, titanium can neither suppress blood coagulation, nor prevent bacterial infections. To address these challenges, tanfloc/heparin polyelectrolyte multilayers on titania nanotubes array surfaces (NT) were developed. The surfaces were characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and water contact angle measurements. To evaluate the hemocompatibility of the surfaces, fibrinogen adsorption, Factor XII activation, and platelet adhesion and activation were analyzed.The antibacterial activity was investigated against Gram-negative P. aeruginosa and Gram-positive S. aureus. Bacterial adhesion and morphology, as well as biofilm formation, were analyzed using fluorescence microscopy and SEM. The anti-thrombogenic properties of the surfaces were demonstrated by significant decreases in fibrinogen adsorption, Factor XII activation, and platelet adhesion and activation. Modifying NT with tanfloc/heparin also reduces the adhesion and proliferation of P. aeruginosa and S. aureus bacteria after 24 hr of incubation, with no biofilm formation. The modified NT surfaces with tanfloc/heparin polyelectrolyte multilayers are a promising biomaterial for use on implant surfaces because of their enhanced blood biocompatibility and antibacterial properties.

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Polyelectrolyte complexes based on alginate/tanfloc: Optimization, characterization and medical application

Cited by 51 publications

References 35 publications

Self-assembled gelatin-ι-carrageenan encapsulation structures for intestinal-targeted release applications

Self-assembled gelatin-ι-carrageenan encapsulation structures for intestinal-targeted release applications

Flocculation Harvesting Techniques for Microalgae: A Review

Enhanced hemocompatibility and antibacterial activity on titania nanotubes with tanfloc/heparin polyelectrolyte multilayers

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