Polydopamine Nanocoating for Effective Photothermal Killing of Bacteria and Fungus upon Near‐Infrared Irradiation

Lei, Wenhui; Ren, Keke; Chen, Tingting; Chen, Xia‐Chao; Li, Bochao; Chang, Hao; Ji, Jian

doi:10.1002/admi.201600767

Cited by 101 publications

(74 citation statements)

References 36 publications

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“…After fixed with 200 µL of glutaraldehyde (2.5%) for 4 h, the cells were dehydrated in alcohol with gradient concentrations (10,20,50,75,80,95, and 100%) sequentially. After fixed with 200 µL of glutaraldehyde (2.5%) for 4 h, the cells were dehydrated in alcohol with gradient concentrations (10,20,50,75,80,95, and 100%) sequentially.…”

Section: Methodsmentioning

confidence: 99%

Highly Effective and Noninvasive Near‐Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min

et al. 2019

Advanced Science

219

138

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Biofilms have been related to the persistence of infections on medical implants, and these cannot be eradicated because of the resistance of biofilm structures. Therefore, a biocompatible phototherapeutic system is developed composed of MoS 2 , IR780 photosensitizer, and arginine–glycine–aspartic acid–cysteine (RGDC) to safely eradicate biofilms on titanium implants within 20 min. The magnetron‐sputtered MoS 2 film possesses excellent photothermal properties, and IR780 can produce reactive oxygen species (ROS) with the irradiation of near‐infrared (NIR, λ = 700–1100 nm) light. Consequently, the combination of photothermal therapy (PTT) and photodynamic therapy (PDT), assisted by glutathione oxidation accelerated by NIR light, can provide synergistic and rapid killing of bacteria, i.e., 98.99 ± 0.42% eradication ratio against a Staphylococcus aureus biofilm in vivo within 20 min, which is much greater than that of PTT or PDT alone. With the assistance of ROS, the permeability of damaged bacterial membranes increases, and the damaged bacterial membranes become more sensitive to heat, thus accelerating the leakage of proteins from the bacteria. In addition, RGDC can provide excellent biosafety and osteoconductivity, which is confirmed by in vivo animal experiments.

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Section: Methodsmentioning

confidence: 99%

Highly Effective and Noninvasive Near‐Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min

et al. 2019

Advanced Science

219

138

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“…Moreover, localized NIR irradiation can promote blood circulation and relieve inflammation of tissues [15], which is beneficial for wound healing. Up to now, various types of photothermal nanomaterials have been explored for applications in the antibacterial therapy, including carbon-based nanoparticles [9,16], metal nanoparticles [12,17] and polymeric nanoparticles [10,18]. Among of them, graphene, as a monolayer of carbon atoms packed into a dense honeycomb crystal structure, has drawn much attention owing to its special two-dimensional structure, strong mechanical property, high photothermal conversion efficiency and excellent biocompatibility [9,19].…”

Section: Introductionmentioning

confidence: 99%

A multifunctional platform with single-NIR-laser-triggered photothermal and NO release for synergistic therapy against multidrug-resistant Gram-negative bacteria and their biofilms

et al. 2020

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Background: Infectious diseases caused by multidrug-resistant (MDR) bacteria, especially MDR Gram-negative strains, have become a global public health challenge. Multifunctional nanomaterials for controlling MDR bacterial infections via eradication of planktonic bacteria and their biofilms are of great interest. Results: In this study, we developed a multifunctional platform (TG-NO-B) with single NIR laser-triggered PTT and NO release for synergistic therapy against MDR Gram-negative bacteria and their biofilms. When located at the infected sites, TG-NO-B was able to selectively bind to the surfaces of Gram-negative bacterial cells and their biofilm matrix through covalent coupling between the BA groups of TG-NO-B and the bacterial LPS units, which could greatly improve the antibacterial efficiency, and reduce side damages to ambient normal tissues. Upon single NIR laser irradiation, TG-NO-B could generate hyperthermia and simultaneously release NO, which would synergistically disrupt bacterial cell membrane, further cause leakage and damage of intracellular components, and finally induce bacteria death. On one hand, the combination of NO and PTT could largely improve the antibacterial efficiency. On the other hand, the bacterial cell membrane damage could improve the permeability and sensitivity to heat, decrease the photothermal temperature and avoid damages caused by high temperature. Moreover, TG-NO-B could be effectively utilized for synergistic therapy against the in vivo infections of MDR Gram-negative bacteria and their biofilms and accelerate wound healing as well as exhibit excellent biocompatibility both in vitro and in vivo. Conclusions: Our study demonstrates that TG-NO-B can be considered as a promising alternative for treating infections caused by MDR Gram-negative bacteria and their biofilms.

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“…As a result, Chinese black ink as the solar absorber coating was required to be further stabilized by atomic layer deposition (ALD) technique to improve the interfacial adhesion to the substrate and prevent the ink dispersing into the water. [71] Beyond above report, a series of PDA coatings have been developed as the photothermal agents for various applications, including photothermal therapy, [101] photothermal antibacteria, [102] photothermal-assisted MD, [103] photo thermalassisted water evaporation, [104,105] and photothermal-assisted crude oil cleanup. [97][98][99] It is well known that the structure of PDA is similar to eumelanin in organism, and thus it would enable PDA coating with excellent light absorption ability.…”

Section: Black-carbon-based Coatingsmentioning

confidence: 99%

Harnessing Solar‐Driven Photothermal Effect toward the Water–Energy Nexus

et al. 2019

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Producing affordable freshwater has been considered as a great societal challenge, and most conventional desalination technologies are usually accompanied with large energy consumption and thus struggle with the trade‐off between water and energy, i.e., the water–energy nexus. In recent decades, the fast development of state‐of‐the‐art photothermal materials has injected new vitality into the field of freshwater production, which can effectively harness abundant and clean solar energy via the photothermal effect to fulfill the blue dream of low‐energy water purification/harvesting, so as to reconcile the water–energy nexus. Driven by the opportunities offered by photothermal materials, tremendous effort has been made to exploit diverse photothermal‐assisted water purification/harvesting technologies. At this stage, it is imperative and important to review the recent progress and shed light on the future trend in this multidisciplinary field. Here, a brief introduction of the fundamental mechanism and design principle of photothermal materials is presented, and the emerging photothermal applications such as photothermal‐assisted water evaporation, photothermal‐assisted membrane distillation, photothermal‐assisted crude oil cleanup, photothermal‐enhanced photocatalysis, and photothermal‐assisted water harvesting from air are summarized. Finally, the unsolved challenges and future perspectives in this field are emphasized. It is envisioned that this work will help arouse future research efforts to boost the development of solar‐driven low‐energy water purification/harvesting.

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Polydopamine Nanocoating for Effective Photothermal Killing of Bacteria and Fungus upon Near‐Infrared Irradiation

Cited by 101 publications

References 36 publications

Highly Effective and Noninvasive Near‐Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min

Highly Effective and Noninvasive Near‐Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min

A multifunctional platform with single-NIR-laser-triggered photothermal and NO release for synergistic therapy against multidrug-resistant Gram-negative bacteria and their biofilms

Harnessing Solar‐Driven Photothermal Effect toward the Water–Energy Nexus

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