Polydopamine/keratin complexes as gatekeepers of mesoporous silica nanoparticles for pH and GSH dual responsive drug delivery

Du, Jinsong; Wang, Lijuan; Han, Xiao; Dou, Jun; Jiang, Xuefeng; Yuan, Jiang

doi:10.1016/j.matlet.2021.129676

Cited by 23 publications

(12 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MSNs@PDA@keratin nanoparticles from Yuan and colleagues, discussed in the previous section, were further loaded with DOX, displaying a loading content of 24.5% and an encapsulating efficiency of 71.3%. MSNs-DOX@PDA@keratin showed good pH and GSH responsiveness, as well as selective toxicity against A549 tumor cells as opposed to normal L929 cells (Figure 8), thus representing a promising approach to promote MSN-based drug delivery [26]. In a previous paper, the same authors further deepened the production of DOXloaded human hair KPNs with high GSH and pH responsiveness [47].…”

Section: Doxorubicin-loaded Human Hair Keratin-based Nanoparticlesmentioning

confidence: 90%

“…Overall, the work by Li and coworkers demonstrates that human hair keratin-EGCG nanoparticles are promising systems for the protection of cells from inflammation due to imbalanced ROS/NOS production. Human hair keratin intrinsic responsiveness to pH, GSH, and trypsin was exploited by Yuan and colleagues to fabricate drug carriers where keratin/poly-dopamine (PDA) complexes functioned as gatekeepers of mesoporous silica nanoparticles (MSNs) [26]. In more detail, PDA was self-polymerized and complexed with iron (III), followed by conjugation with keratin.…”

Section: Human Hair Keratin-based Nanoparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Keratin-Based Nanoparticles as Drug Delivery Carriers

Ferroni

Varchi

2021

Applied Sciences

View full text Add to dashboard Cite

Keratin is a structural protein of mammalian tissues and birds, representing the principal constituent of hair, nails, skin, wool, hooves, horns, beaks, and feathers, and playing an essential role in protecting the body from external harassment. Due to its intrinsic features such as biocompatibility, biodegradability, responsiveness to specific biological environment, and physical–chemical properties, keratin has been extensively explored in the production of nanocarriers of active principles for different biomedical applications. In the present review paper, we aimed to give a literature overview of keratin-based nanoparticles produced starting from human hair, wool, and chicken feathers. Along with the chemical and structural description of keratin nanoparticles, selected in vitro and in vivo biological data are also discussed to provide a more comprehensive framework of possible fields of application of this protein. Despite the considerable number of papers describing the production and use of keratin nanoparticles as carries of anticancer and antimicrobial drugs or as hemostatic and wound healing materials, still, efforts are needed to implement keratin nanoparticles towards their clinical application.

show abstract

Section: Doxorubicin-loaded Human Hair Keratin-based Nanoparticlesmentioning

confidence: 90%

Section: Human Hair Keratin-based Nanoparticlesmentioning

confidence: 99%

Keratin-Based Nanoparticles as Drug Delivery Carriers

Ferroni

Varchi

2021

Applied Sciences

View full text Add to dashboard Cite

show abstract

“…Apart from a single trigger, several studies have explored the utilization of multiple stimuli (two or more) either to control the release of therapeutic guests by unlocking the capping or the conveyance of the MSNs [ 297 ]. In this regard, various multiple stimuli combinations employed in the fabrication of advanced prototypes of MSNs include pH, GSH, or H 2 O 2 -responsive [ 298 ], redox-enhanced pH-responsive [ 297 , 299 ], thermos- and pH-responsive [ 261 ], pH- and GSH-responsive [ 300 , 301 ], GSH- and NIR-triggered [ 302 ] nanocomposites. These composites with multiple stimuli-triggered delivery or degradation offer more advantages than the single stimuli-based composites.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications

et al. 2022

View full text Add to dashboard Cite

Despite exceptional morphological and physicochemical attributes, mesoporous silica nanoparticles (MSNs) are often employed as carriers or vectors. Moreover, these conventional MSNs often suffer from various limitations in biomedicine, such as reduced drug encapsulation efficacy, deprived compatibility, and poor degradability, resulting in poor therapeutic outcomes. To address these limitations, several modifications have been corroborated to fabricating hierarchically-engineered MSNs in terms of tuning the pore sizes, modifying the surfaces, and engineering of siliceous networks. Interestingly, the further advancements of engineered MSNs lead to the generation of highly complex and nature-mimicking structures, such as Janus-type, multi-podal, and flower-like architectures, as well as streamlined tadpole-like nanomotors. In this review, we present explicit discussions relevant to these advanced hierarchical architectures in different fields of biomedicine, including drug delivery, bioimaging, tissue engineering, and miscellaneous applications, such as photoluminescence, artificial enzymes, peptide enrichment, DNA detection, and biosensing, among others. Initially, we give a brief overview of diverse, innovative stimuli-responsive (pH, light, ultrasound, and thermos)- and targeted drug delivery strategies, along with discussions on recent advancements in cancer immune therapy and applicability of advanced MSNs in other ailments related to cardiac, vascular, and nervous systems, as well as diabetes. Then, we provide initiatives taken so far in clinical translation of various silica-based materials and their scope towards clinical translation. Finally, we summarize the review with interesting perspectives on lessons learned in exploring the biomedical applications of advanced MSNs and further requirements to be explored. Graphical Abstract

show abstract

“…For instance, keratin is the major structural fibrous protein to form hair. It can be employed to seal the mesopores of MSNs, as it presents cysteine residues throughout its structure able to form disulfide bonds, providing stimuli-responsiveness and non-immunogenicity [ 16 ]. A rather simple strategy to avoid premature drug release involves taking advantage of having a silica framework to promote further silica condensation.…”

Section: Redox-responsive Gatekeepersmentioning

confidence: 99%

Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates

Gisbert-Garzarán

Vallet‐Regí

2021

Nanomaterials

View full text Add to dashboard Cite

Mesoporous silica nanoparticles have been widely applied as carriers for cancer treatment. Among the different types of stimuli-responsive drug delivery systems, those sensitive to redox stimuli have attracted much attention. Their relevance arises from the high concentration of reductive species that are found within the cells, compared to bloodstream, which leads to the drug release taking place only inside cells. This review is intended to provide a comprehensive overview of the most recent trends in the design of redox-responsive mesoporous silica nanoparticles. First, a general description of the biological rationale of this stimulus is presented. Then, the different types of gatekeepers that are able to open the pore entrances only upon application of reductive conditions will be introduced. In this sense, we will distinguish among those targeted and those non-targeted toward cancer cells. Finally, a new family of bridged silica nanoparticles able to degrade their structure upon application of this type of stimulus will be presented.

show abstract

Polydopamine/keratin complexes as gatekeepers of mesoporous silica nanoparticles for pH and GSH dual responsive drug delivery

Cited by 23 publications

References 16 publications

Keratin-Based Nanoparticles as Drug Delivery Carriers

Keratin-Based Nanoparticles as Drug Delivery Carriers

Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications

Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates

Contact Info

Product

Resources

About