Polydopamine/cysteine surface modified hemocompatible poly(vinylidene fluoride) hollow fiber membranes for hemodialysis

Abstract

Membrane surface design is significant for the development and application of synthetic polymer hemodialysis membranes. In this study, the influence of zwitterionic cysteine on poly(vinylidene fluoride) (PVDF) hollow fiber membrane was investigated. The polydopamine layer was formed through dopamine self-polymerization on PVDF membrane surface, and then cysteine was covalent grafted onto the layer to improve the anti-biofouling property and hemocompatibility. The elementary composition of membrane surfaces was characterized by X-ray photoelectron spectroscopy. The influence of polydopamine and cysteine on modified membrane surface morphologies was studied by field emission scanning electron microscopy. The modified PVDF membranes were confirmed to have excellent hydrophilicity, stable mechanical properties and good hemocompatibility (dynamic and static anti-protein adsorption, hemolysis ratio, plasma coagulation). And these properties were increased with the incorporation of polydopamine and cysteine. The optimized modified membranes exhibited high pure water flux (∼ 195.5 L/m h at 0.1 MPa) and selectivity (clearance ratio of urea and lysozyme was 75.1 and 55.4%, and rejection rate of bovine serum albumin was 98.8%). This work provides a surface modification method of PVDF hollow fiber membranes and suggests a potential application of PVDF membranes in hemodialysis field. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2869-2877, 2018.

Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO)

“…Grafting polymer onto the surface by chemical methods is the most common approaches in material modification. Initially, the researchers conducted a series of hydrophobic modification studies to reduce blood leakage, including poly (L-lactide) (PLLA), poly (choline phosphate methacrylate) copolymers, and poly (2-methoxyethyl acrylate) (PMEA) [67]; however, hydrophobic surface can aggravate protein adhesion fouling [68]. Hydrophilic modification is an effective method to enhance the biocompatibility, such as polyethylene oxide (PEO) or poly (ethylene glycol) (PEG), which are employed to enhance the surface hydrophilicity of materials and achieve antifouling ability [69][70][71].…”

Chemical Degradation of PSF-PUR Blend Hollow Fiber Membranes—Assessment of Changes in Properties and Morphology after Hydrolysis

“…Furthermore, helpful methods to eliminate fouling can be, for example, heat and plasma treatment [ 4 , 34 , 35 , 36 , 37 ], coating or grafting of hydrophilic polymers onto membranes’ surfaces [ 33 , 35 , 38 , 39 , 40 , 41 , 42 , 43 ], or through the addition of hydrophilic pore precursors to a polymer solution or other admixture like nanoparticles [ 6 , 19 , 25 , 44 , 45 , 46 , 47 , 48 ]. The modification could be influenced by an increase of the hydraulic permeability and/or the hydrophilicity of membranes.…”

Effects of mussel‐inspired co‐deposition of 2‐hydroxymethyl methacrylate and poly (2‐methoxyethyl acrylate) on the hydrophilicity and binding tendency of common hemodialysis membranes: Molecular dynamics simulations and molecular docking studies

“…The co-deposition of PDA and the ZW structure of cysteine on polyvinylidene fluoride (PVDF) hollow fiber membranes was suggested by An et al 14 Methacrylate ZW-PDA modification through a one-step co-deposition was also reported by Shahkaramipour et al 21 for wastewater treatment applications. The methodology introduced sulfobetaine methacrylate (SBMA)-PDA immobilized on a polyether sulfone (PES) ultrafiltration membrane.…”

“…As an alternative to bulk casting solution modification, PDA can be coated on polymeric structure surfaces. 14 Several membrane materials and different membrane geometries can be enhanced with such a middle adhesive structure; indeed, DA-assisted immobilization of different structures has been reported for a variety of different polymers and zwitterionic (ZW) structures. [15][16][17][18] The mechanism through which the adhesive nature of DA works is as follows, amino and catechol groups on the surface of the DA monomers oxypolymerize to PDA within a basic environment and in the absence of air.…”