Polydopamine-coated mesoporous silica nanoparticles for multi-responsive drug delivery and combined chemo-photothermal therapy

Lei, Wei; Sun, Changshan; Jiang, Tongying; Gao, Yikun; Yang, Yang; Zhao, Qinfu; Wang, Siling

doi:10.1016/j.msec.2019.110103

Cited by 146 publications

(61 citation statements)

References 40 publications

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“…Mesoporous silica nanoparticle carriers are a type of SNPs which are suitable for drug delivery (Almeida et al, 2014;Gao et al, 2019). The large internal pore volume enables them to encapsulate the maximum amount of anticancer drugs, and the supramolecular components act as a cap, allowing capture and release of drugs (Cheng et al, 2019;Lei et al, 2019). Due to better pharmacokinetics and treatment efficacy, as well as high stability, SNPs are considered one of the best vehicles for drug delivery (Zhang F. et al, 2017;Xu et al, 2019).…”

Section: Inorganic Npsmentioning

confidence: 99%

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Yao

Zhou

Liu

et al. 2020

Front. Mol. Biosci.

599

346

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Nanotechnology has been extensively studied and exploited for cancer treatment as nanoparticles can play a significant role as a drug delivery system. Compared to conventional drugs, nanoparticle-based drug delivery has specific advantages, such as improved stability and biocompatibility, enhanced permeability and retention effect, and precise targeting. The application and development of hybrid nanoparticles, which incorporates the combined properties of different nanoparticles, has led this type of drug-carrier system to the next level. In addition, nanoparticle-based drug delivery systems have been shown to play a role in overcoming cancer-related drug resistance. The mechanisms of cancer drug resistance include overexpression of drug efflux transporters, defective apoptotic pathways, and hypoxic environment. Nanoparticles targeting these mechanisms can lead to an improvement in the reversal of multidrug resistance. Furthermore, as more tumor drug resistance mechanisms are revealed, nanoparticles are increasingly being developed to target these mechanisms. Moreover, scientists have recently started to investigate the role of nanoparticles in immunotherapy, which plays a more important role in cancer treatment. In this review, we discuss the roles of nanoparticles and hybrid nanoparticles for drug delivery in chemotherapy, targeted therapy, and immunotherapy and describe the targeting mechanism of nanoparticle-based drug delivery as well as its function on reversing drug resistance.

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Section: Inorganic Npsmentioning

confidence: 99%

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Yao

Zhou

Liu

et al. 2020

Front. Mol. Biosci.

599

346

View full text Add to dashboard Cite

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“…After the CS polymer was further grafted onto the surface of the HMSS to form HMSS-N=N-CS, the ξ potential reverted to +32. The LE of HMSS-N=N-CS/DOX was 35.2%, which was much larger than that of other DOX-loaded mesoporous silica delivery systems [16,43]. The high LE of DOX in HMSS nanocarriers was attributed to the hollow cavity, large surface area and mesoporous network, which could be used as a drug reservoir.…”

Section: Resultsmentioning

confidence: 84%

“…Over the past two decades, mesoporous silica spheres (MSSs) with mesopores ranging from 2-50 nm in size have been established as stimuli-responsive drug carriers [7,8] since MSSs have a remarkably large pore volume and high surface area for high drug loading capacity, well-organized pore structure, an easily functionalized surface and good biocompatibility [9,10]. Furthermore, hollow mesoporous silica sphere (HMSS) nanoparticles with a mesoporous shell structure and a hollow cavity are superior to conventional MSSs because the hollow structure can efficiently hold more drugs with a higher storage capacity than MSSs carriers [11,12].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-capped enzyme-responsive hollow mesoporous silica nanoplatforms for colon-specific drug delivery

Cai

Han

Liu

et al. 2020

Preprint

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An enzyme-responsive colon-specific delivery system was developed based on hollow mesoporous silica spheres (HMSS) to which biodegradable chitosan (CS) was attached via cleavable azo bonds (HMSS-N=N-CS). Doxorubicin (DOX) was encapsulated in a noncrystalline state in the hollow cavity and mesopores of HMSS with the high loading amount of 35.2%. In vitro drug release proved that HMSS-N=N-CS/DOX performed enzyme-responsive drug release. The grafted CS could increase the biocompatibility and stability, and reduce the protein adsorption on HMSS. Gastrointestinal mucosa irritation and cell cytotoxicity results indicated the good biocompatibility of HMSS and HMSS-N=N-CS. Cellular uptake results indicated that the uptake of DOX was obviously increased after HMSS-N=N-CS/DOX was preincubated with a colonic enzyme mixture. HMSS-N=N-CS/DOX incubated with colon enzymes showed increased cytotoxicity, and its IC 50 value was three times lower than that of HMSS-N=N-CS/DOX group without colon enzymes. The present work lays the foundation for subsequent research on mesoporous carriers for oral colon-specific drug delivery.

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“…PDA-modified MOFs have been reported and applied in biosensors [ 33 ], the removal of environmental pollutants [ 34 , 35 , 36 ], CO 2 capture [ 37 ], and cancer therapy [ 38 , 39 , 40 ]. Considering the sensitivity of PDA to experimental stimuli [ 41 , 42 , 43 ], PDA-modified Fe-MOFs have great potential in delivering pesticides to address the limitations mentioned above.…”

Section: Introductionmentioning

confidence: 99%

Polydopamine-Modified Metal–Organic Frameworks, NH2-Fe-MIL-101, as pH-Sensitive Nanocarriers for Controlled Pesticide Release

Shan

Zhang

et al. 2020

Nanomaterials

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Recently, metal–organic frameworks (MOFs) have become a dazzling star among porous materials used in many fields. Considering their intriguing features, MOFs have great prospects for application in the field of sustainable agriculture, especially as versatile pesticide-delivery vehicles. However, the study of MOF-based platforms for controlled pesticide release has just begun. Controlled pesticide release responsive to environmental stimuli is highly desirable for decreased agrochemical input, improved control efficacy and diminished adverse effects. In this work, simple, octahedral, iron-based MOFs (NH2-Fe-MIL-101) were synthesized through a microwave-assisted solvothermal method using Fe3+ as the node and 2-aminoterephthalic acid as the organic ligand. Diniconazole (Dini), as a model fungicide, was loaded into NH2-Fe-MIL-101 to afford Dini@NH2-Fe-MIL-101 with a satisfactory loading content of 28.1%. The subsequent polydopamine (PDA) modification could endow Dini with pH-sensitive release patterns. The release of Dini from PDA@Dini@NH2-Fe-MIL-101 was much faster in an acidic medium compared to that in neutral and basic media. Moreover, Dini@NH2-Fe-MIL-101 and PDA@Dini@NH2-Fe-MIL-101 displayed good bioactivities against the pathogenic fungus causing wheat head scab (Fusarium graminearum). This research sought to reveal the feasibility of versatile MOFs as a pesticide-delivery platform in sustainable crop protection.

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Polydopamine-coated mesoporous silica nanoparticles for multi-responsive drug delivery and combined chemo-photothermal therapy

Cited by 146 publications

References 40 publications

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Chitosan-capped enzyme-responsive hollow mesoporous silica nanoplatforms for colon-specific drug delivery

Polydopamine-Modified Metal–Organic Frameworks, NH2-Fe-MIL-101, as pH-Sensitive Nanocarriers for Controlled Pesticide Release

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