Polydopamine-Modified Metal–Organic Frameworks, NH2-Fe-MIL-101, as pH-Sensitive Nanocarriers for Controlled Pesticide Release

Shan, Yongpan; Xu, Chunli; Zhang, Hongjun; Chen, Huiping; Bilal, Muhammad; Shujun, Niu; Cao, Lidong; Huang, Qiliang

doi:10.3390/nano10102000

Cited by 35 publications

(14 citation statements)

References 52 publications

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“…A previously published method was adopted to generate PDA-coated CUR-Zn-MOFs, with minor changes (Shan et al., 2020 ). Briefly, 19 mg of dopamine was dissolved in a Tris buffer solution (10 mM, pH 8.5) while stirring.…”

Section: Methodsmentioning

confidence: 99%

Improving curcumin bactericidal potential against multi-drug resistant bacteria via its loading in polydopamine coated zinc-based metal–organic frameworks

et al. 2023

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Multi-drug resistant (MDR) bactearial strains have posed serious health issues, thus leading to a significant increase in mortality, morbidity, and the expensive treatment of infections. Metal-organic frameworks (MOFs), comprising metal ions and a variety of organic ligands, have been employed as an effective drug deliveryy vehicle due to their low toxicity, biodegradability, higher structural integrity and diverse surface functionalities. Polydopamine (PDA) is a versatile biocompatible polymer with several interesting properties, including the ability to adhere to biological surfaces. As a result, modifying drug delivery vehicles with PDA has the potential to improve their antimicrobial properties. This work describes the preparation of PDA-coated Zn-MOFs for improving curcumin’s antibacterial properties against S. aureus and E. coli. Powder X-ray diffraction (P-XRD), FT-IR, scanning electron microscopy (SEM), and DLS were utilized to characterize PDA-coated Zn-MOFs. The curcumin loading and in vitro release of the prepared MOFs were also examined. Finally, the MOFs were tested for bactericidal ability against E. coli and S. aureus using an anti-bacterial assay and surface morphological analysis. Smaller size MOFs were capable of loading and releasing curcumin. The findings showed that as curcumin was encapsulated into PDA-coated MOFs, its bactericidal potential was significantly enhanced, and the findings were further supported by SEM which indicated the complete morphological distortion of the bacteria after treatment with PDA-Cur-Zn-MOFs. These studies clearly indicate that the PDA-Cur-Zn-MOFs developed in this study are extremely promising for long-term release of drugs to treat a wide range of microbial infections.

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Section: Methodsmentioning

confidence: 99%

Improving curcumin bactericidal potential against multi-drug resistant bacteria via its loading in polydopamine coated zinc-based metal–organic frameworks

et al. 2023

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“…In a later study by Shan et al, 67 controlled release properties were enhanced by the elimination of burst effects, by integrating diniconazole-loaded NH 2 -MIL-101 with polydopamine (PDA). Loading of diniconazole into the amine-functionalized NH 2 -MIL-101 was performed at a ratio of 1:1 in dichloromethane at room temperature, achieving a loading of 28% by weight.…”

Section: Mofs For Pesticide Deliverymentioning

confidence: 99%

Metal–Organic Frameworks as Potential Agents for Extraction and Delivery of Pesticides and Agrochemicals

et al. 2022

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Pesticide contamination is a global issue, affecting nearly 44% of the global farming population, and disproportionately affecting farmers and agricultural workers in developing countries. Despite this, global pesticide usage is on the rise, with the growing demand of global food production with increasing population. Different types of porous materials, such as carbon and zeolites, have been explored for the remediation of pesticides from the environment. However, there are some limitations with these materials, especially due to lack of functional groups and relatively modest surface areas. In this regard, metal–organic frameworks (MOFs) provide us with a better alternative to conventionally used porous materials due to their versatile and highly porous structure. Recently, a number of MOFs have been studied for the extraction of pesticides from the environment as well as for targeted and controlled release of agrochemicals. Different types of pesticides and conditions have been investigated, and MOFs have proved their potential in agricultural applications. In this review, the latest studies on delivery and extraction of pesticides using MOFs are systematically reviewed, along with some recent studies on greener ways of pest control through the slow release of chemical compounds from MOF composites. Finally, we present our insights into the key issues concerning the development and translational applications of using MOFs for targeted delivery and pesticide control.

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“…It has been widely used in material storage, separation, purification, catalysis, sensing, biological imaging, energy storage, and drug delivery. − Compared with traditional materials, MOFs have many unique properties in drug delivery systems. The large porosity, high porosity, and huge specific surface area of MOFs contribute to improved drug loading efficiency, while its easy surface functionalization, good stability, and biocompatibility further expand its availability. , Based on the extensive research of MOFs in drug delivery and biomedicine, MOF-based multifunctional PDS has attracted more and more attention in recent years. − For example, Shan et al synthesized a Fe-based MOF (NH 2 -Fe-MIL-101) for diniconazole (Dini) delivery. They found that the NH 2 -Fe-MIL-101 nanocarrier exhibited a good pesticide loading effect, with a loading rate of 28.1% for Dini.…”

Section: Introductionmentioning

confidence: 99%

“…They found that the NH 2 -Fe-MIL-101 nanocarrier exhibited a good pesticide loading effect, with a loading rate of 28.1% for Dini. After surface modification of polydopamine, this PDS exhibits pH responsive controlled release performance . UiO-66 is a Zr-based MOF with excellent stability and high pesticide loading capacity.…”

Section: Introductionmentioning

confidence: 99%

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Environmentally Friendly Zr-Based MOF for Pesticide Delivery: Ultrahigh Loading Capacity, pH-Responsive Release, Improved Leaf Affinity, and Enhanced Antipest Activity

et al. 2022

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The stimuli responsive pesticide delivery system (PDS) has drawn increasing attention in recent years, a system which can effectively improve the utilization of pesticides. In the current research, we report a pH responsive PDS by using carboxymethyl cellulose (CMC) modified Zr-based metal organic frameworks (UiO-66-NH2) as the nanocarrier for acetamiprid (ATP). UiO-66-NH2-CMC possesses a large surface area and abundant pores, which can effectively load ATP, and the loading rate is as high as 90.79%. Compared with free ATP, the ATP@UiO-66-NH2-CMC nanopesticide exhibits pH responsive controlled release behavior, and the pesticide can sustained release to the medium. In addition, it also shows improved leaf affinity, which makes it easier to wet the leaf surface and improve the utilization of pesticide. Therefore, ATP@UiO-66-NH2-CMC displays better antipest activity against aphids than free ATP does. Meanwhile, ATP@UiO-66-NH2-CMC shows no negative effects on the germination and growth of maize, showing good biosafety. Moreover, the ATP@UiO-66-NH2-CMC nanopesticide does not contain any toxic organic solvents or additives. Therefore, we hope that it can be a suitable candidate for plant protection and sustainable agriculture.

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Polydopamine-Modified Metal–Organic Frameworks, NH2-Fe-MIL-101, as pH-Sensitive Nanocarriers for Controlled Pesticide Release

Cited by 35 publications

References 52 publications

Improving curcumin bactericidal potential against multi-drug resistant bacteria via its loading in polydopamine coated zinc-based metal–organic frameworks

Improving curcumin bactericidal potential against multi-drug resistant bacteria via its loading in polydopamine coated zinc-based metal–organic frameworks

Metal–Organic Frameworks as Potential Agents for Extraction and Delivery of Pesticides and Agrochemicals

Environmentally Friendly Zr-Based MOF for Pesticide Delivery: Ultrahigh Loading Capacity, pH-Responsive Release, Improved Leaf Affinity, and Enhanced Antipest Activity

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