Polydopamine: a bioinspired adhesive and surface modification platform

Abstract

Polydopamine is a biopolymer that is gaining widespread interest as a surface modifying agent due to its simplicity of preparation, versatility and biocompatibility. The material was first described during electrochemical studies of dopamine, but recognition of its structural similarity to key components of mussel adhesive proteins, which are able to adhere to a diverse range of surfaces in water, has led to its incorporation into a host of composite materials. This review will examine some of the emerging investigations into the complex mechanism of polydopamine formation, proposed structures and potential applications, with an emphasis on its use in biomedicine. © 2021 Society of Industrial Chemistry.

Melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy

“…Moreover, melanin coatings can be used as a secondary reaction platform to adhere functional components such as long-chain molecules, biomolecules, and metal films to their surfaces to form functional coatings. Due to these benefits, the application of melanin coatings in the field of surface modification has become an important research direction and is widely used in biomedical, energy, and industrial settings [ 69 – 71 ]. As PDA-based surface modification is the most widely studied among MNPs, this subsection focuses on PDA-based surface modification strategies.…”

The effects of process parameters on polydopamine coatings employed in tissue engineering applications

“…Compared to other coating substances, including proteins ( Gennadios, 2002 ), particular peptide sequences ( Pagel and Beck-Sickinger, 2017 ), ceramics ( Montazerian et al, 2022 ), and metals ( Yin et al, 2021 ), polydopamine (PDA), a melanin-like mussel-inspired coating polymer ( Ghorbani et al, 2022 ), possesses a variety of desirable properties, such as outstanding adhesion features ( Ghalandari et al, 2021 ; Feinberg and Hanks, 2022 ), extraordinary hydrophilicity ( Li et al, 2018 ), biodegradability ( Zhang and King, 2020 ), uniform shape ( Saeed et al, 2021 ), biocompatibility ( Zeng et al, 2020 ), and thermal stability ( Yim et al, 2022 ). Furthermore, its biological properties, including enhanced cellular proliferation, improved bioactivity, free-radical scavenging activities, metal ion chelating capacity, and anti-bacterial capability, originate from its catecholamine and hydroxyl functional groups ( Yu et al, 2017 ; Ghorbani et al, 2019b , 2019a ; Deng et al, 2021 ).…”

Thermoresponsive catechol end‐functionalized polymers/CBPQT4+, 4Cl− supramolecular assembly

“…Nature is a fascinating source of inspiration for stimulating research in materials science. Indeed, recent progress in the adhesion mechanism of marine mussels 1 has led to the emergence of a new generation of materials mimicking the properties of these natural systems and finding various applications in coatings, 2 adhesives 3 and biomaterials 4 . In these materials, the catechol moiety, according to its ability to strongly binds onto organic and inorganic substrates, was used as versatile building block for the design of a large range of macromolecular architectures featuring fascinating properties and functions 5 .…”