Polydatin (PD) inhibits IgE-mediated passive cutaneous anaphylaxis in mice by stabilizing mast cells through modulating Ca2+ mobilization

Yuan, Mei‐Chun; Li, Jianjie; JingZhang, Lv; Mo, Xucheng; Yang, Chengbin; Chen, Xiangdong; Liu, Zhigang; Liu, Jie

doi:10.1016/j.taap.2012.08.024

Cited by 25 publications

(16 citation statements)

References 30 publications

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“…The possible mechanism is that PD suppresses high-affinity IgE receptors-mediated Ca 2þ mobilization by inhibiting Ca 2þ entry through Ca 2þ release-activated Ca 2þ channel, which are the major contributors to PD-induced mast cell stabilization (Yuan et al, 2012).…”

Section: Immunoregulatory Effectsmentioning

confidence: 99%

Polydatin: A review of pharmacology and pharmacokinetics

Peng

Zhang

2013

Pharmaceutical Biology

210

162

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Context: Polydatin, also named piceid (3,4 0 ,5-trihydroxystilbene-3-b-D-glucoside, PD), is a monocrystalline compound isolated from Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae), but is also detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. There are numerous investigations reported of PD in the past 22 years, but they are usually scattered across various publications, which may block further research and clinical use of PD. Objective: The article summarizes and evaluates the published scientific information of PD pharmacological effects and pharmacokinetics since 1990. Materials and methods: The information from 98 cases included in this review was compiled using major databases such as MEDLINE, Elsevier, Springer, PubMed, Scholar and CNKI. Results: Numerous pharmacological investigations of PD mainly focus on cardiovascular effects, neuroprotection, anti-inflammatory and immunoregulatory effects, anti-oxidation, anti-tumor, liver and lung protection, etc. Conclusion: A great number of pharmacological and pharmacokinetic investigations in the past 22 years have demonstrated that PD has favorable therapeutic properties, indicating its potential as an effective material. However, further research is needed to explore its molecular mechanisms of action and definitive target proteins.

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Section: Immunoregulatory Effectsmentioning

confidence: 99%

Polydatin: A review of pharmacology and pharmacokinetics

Peng

Zhang

2013

Pharmaceutical Biology

210

162

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“…Previous studies have demonstrated that PD has many bioactivities such as anti-platelet aggregation, against shock [4,9], anti-ischemia/reperfusion injury [7], hepato-protective effect [10,11], neuroprotective activity [12,13], lung protective effects [14], anti-inflammatory [15], immune-regulating functions [16], and anti-tumor activity [17,18]. But most of the anti-tumor studies are concerning solid tumors, little is known concerning the acute monocytic leukemia.…”

Section: Discussionmentioning

confidence: 99%

Polydatin Induces Apoptosis and Inhibits Growth of Acute Monocytic Leukemia Cells

Wang

Luo

Lü

et al. 2015

J Biochem & Molecular Tox

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Polydatin (PD), a component isolated from Polygonum cuspidatum, has various activities such as inhibiting platelet aggregation, lowering level of blood lipid, reducing lipid peroxidation, and so on. However, the antitumor activity of PD has been poorly reported. In the present study, effect of PD on cell proliferation was evaluated by Cell Counting Kit-8, and cell cycle and apoptosis were investigated by flow cytometry. Meanwhile, the protein expression level of Bc1-2, Bax, cyclin A, cyclin B, and cyclin D1, which associated with apoptosis and cell cycle were analyzed by Western blotting. Results show that PD could effectively inhibit the growth, arrest cells in S phase, and induce apoptosis of acute monocytic leukemia cell line THP-1; meanwhile, expression of cyclin D1 and Bc1-2 decreased significantly, and expression of Bax and cyclin A increased notably. All results suggest that PD maybe a potential therapeutic strategy for acute monocytic leukemia.

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“…polydatin (Yuan et al, 2012). The phenylethanoid hydroxytyrosol and its ester derivative, oleuropein, inhibited degranulation elicited by various stressors at a relatively high concentration of 100 M (Persia et al, 2014).…”

Section: Phenolsmentioning

confidence: 98%