Polydatin Attenuates Hypoxic Pulmonary Hypertension and Reverses Remodeling through Protein Kinase C Mechanisms

Miao, Qing; Shi, Xiaopeng; Ye, Ming-Xiang; Zhang, Jin; Miao, Song; Wang, Siwang; Li, Bo; Jiang, Xingxing; Zhang, Song; Hu, Nan; Li, Juan; Zhang, Jiän

doi:10.3390/ijms13067776

Cited by 20 publications

(16 citation statements)

References 33 publications

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“…Intravenous administration of PD (20 mg/kg) causes a significant decrease in the release of creatine phosphokinase and LDH from the damaged myocardium by activation of protein kinase C-ATP-sensitive K þ channel-dependent signaling (Miao et al, 2011(Miao et al, , 2012. The electrophysiological mechanism is that PD shortens the duration of 50% repolarization (APD 50 ) and 90% repolarization (APD 90 ), but has no effects on resting potential, overshoot (OS), amplitude of action potential (APA) and the maximal rate of depolarization in phase 0 (Vmax) in normal papillary muscles.…”

Section: Pharmacological Effectsmentioning

confidence: 99%

“…On the other hand, PD also ameliorates SOD activity and injured alveoli rate and reduces MDA content to protect against lung I/R injury (Wang et al, 2008). Moreover, PD regulates the levels of NO, Ang II and ET, which are closely related to pulmonary hypertension remodeling system, and abates the forced activation of PKC signaling by thymeleatoxin (Miao et al, 2012). PD significantly protects against rat pulmonary micro VECs injury in vitro induced by hypoxia through preventing the increases of LDH activity and vascular endothelial growth factor (VEGF) expression (Wang et al, 2001).…”

Section: Lung Protective Effectsmentioning

confidence: 99%

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Polydatin: A review of pharmacology and pharmacokinetics

Peng

Zhang

2013

Pharmaceutical Biology

201

150

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Context: Polydatin, also named piceid (3,4 0 ,5-trihydroxystilbene-3-b-D-glucoside, PD), is a monocrystalline compound isolated from Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae), but is also detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. There are numerous investigations reported of PD in the past 22 years, but they are usually scattered across various publications, which may block further research and clinical use of PD. Objective: The article summarizes and evaluates the published scientific information of PD pharmacological effects and pharmacokinetics since 1990. Materials and methods: The information from 98 cases included in this review was compiled using major databases such as MEDLINE, Elsevier, Springer, PubMed, Scholar and CNKI. Results: Numerous pharmacological investigations of PD mainly focus on cardiovascular effects, neuroprotection, anti-inflammatory and immunoregulatory effects, anti-oxidation, anti-tumor, liver and lung protection, etc. Conclusion: A great number of pharmacological and pharmacokinetic investigations in the past 22 years have demonstrated that PD has favorable therapeutic properties, indicating its potential as an effective material. However, further research is needed to explore its molecular mechanisms of action and definitive target proteins.

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Section: Pharmacological Effectsmentioning

confidence: 99%

Section: Lung Protective Effectsmentioning

confidence: 99%

Polydatin: A review of pharmacology and pharmacokinetics

Peng

Zhang

2013

Pharmaceutical Biology

201

150

View full text Add to dashboard Cite

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“…It is a glycoside of resveratrol. Previous studies have shown that polydatin exerts several pharmacological effects, including anti-inflammation [ 20 – 23 ], anti-oxidant [ 24 , 25 ], anti-allergy [ 26 ], anti-cancer [ 27 ], lipid-lowering [ 28 , 29 ], and cardiovascular- protection effects [ 30 , 31 ]. We found that polydatin could improve lipid and glucose metabolism in STZ-induced diabetic rats and regulate GCK and LDLR expression [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9)

Wang

et al. 2016

Cardiovasc Diabetol

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BackgroundAbnormalities in lipid and glucose metabolism are constantly observed in type 2 diabetes. However, these abnormalities can be ameliorated by polydatin. Considering the important role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in metabolic diseases, we explore the possible mechanism of polydatin on lipid and glucose metabolism through its effects on PCSK9.MethodsAn insulin-resistant HepG2 cell model induced by palmitic acid (PA) and a db/db mice model were used to clarify the role of polydatin on lipid and glucose metabolism.ResultsIn insulin-resistant HepG2 cells, polydatin upregulated the protein levels of LDLR and GCK but repressed PCSK9 protein expression, besides, polydatin also inhibited the combination between PCSK9 and LDLR. Knockdown and overexpression experiments indicated that polydatin regulated LDLR and GCK expressions through PCSK9. In the db/db mice model, we found that polydatin markedly enhanced GCK and LDLR protein levels, and inhibited PCSK9 expression in the liver. Molecular docking assay was further performed to analyze the possible binding mode between polydatin and the PCSK9 crystal structure (PDB code: 2p4e), which indicated that steady hydrogen bonds formed between polydatin and PCSK9.ConclusionsOur study indicates that polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating PCSK9.

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“…Previous studies have demonstrated that PD has many bioactivities such as anti-platelet aggregation, against shock [4,9], anti-ischemia/reperfusion injury [7], hepato-protective effect [10,11], neuroprotective activity [12,13], lung protective effects [14], anti-inflammatory [15], immune-regulating functions [16], and anti-tumor activity [17,18]. But most of the anti-tumor studies are concerning solid tumors, little is known concerning the acute monocytic leukemia.…”

Section: Discussionmentioning

confidence: 99%

Polydatin Induces Apoptosis and Inhibits Growth of Acute Monocytic Leukemia Cells

Wang

Luo

Lü

et al. 2015

J Biochem & Molecular Tox

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Polydatin (PD), a component isolated from Polygonum cuspidatum, has various activities such as inhibiting platelet aggregation, lowering level of blood lipid, reducing lipid peroxidation, and so on. However, the antitumor activity of PD has been poorly reported. In the present study, effect of PD on cell proliferation was evaluated by Cell Counting Kit-8, and cell cycle and apoptosis were investigated by flow cytometry. Meanwhile, the protein expression level of Bc1-2, Bax, cyclin A, cyclin B, and cyclin D1, which associated with apoptosis and cell cycle were analyzed by Western blotting. Results show that PD could effectively inhibit the growth, arrest cells in S phase, and induce apoptosis of acute monocytic leukemia cell line THP-1; meanwhile, expression of cyclin D1 and Bc1-2 decreased significantly, and expression of Bax and cyclin A increased notably. All results suggest that PD maybe a potential therapeutic strategy for acute monocytic leukemia.

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Polydatin Attenuates Hypoxic Pulmonary Hypertension and Reverses Remodeling through Protein Kinase C Mechanisms

Cited by 20 publications

References 33 publications

Polydatin: A review of pharmacology and pharmacokinetics

Polydatin: A review of pharmacology and pharmacokinetics

Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9)

Polydatin Induces Apoptosis and Inhibits Growth of Acute Monocytic Leukemia Cells

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