Polycystic ovary syndrome, infertility, familial thrombophilia, familial hypofibrinolysis, recurrent loss of in vitro fertilized embryos, and miscarriage

Glueck, Charles J.; Awadalla, Sherif G.; Phillips, Harvey; Cameron, Dan; Wang, Ping; Fontaine, R

doi:10.1016/s0015-0282(00)00630-0

Cited by 58 publications

(33 citation statements)

References 4 publications

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“…In other studies of women with PCOS, we have previously shown that the 4G4G PAI-1 mutation [19] was an independent determinant of serious pregnancy complications and that PAI-1 activity was an independent determinant of miscarriage [20][21][22][23] and recurrent pregnancy loss [24]. Elevated levels of PAI-1 have been associated with increased cardiovascular risk and increased thrombogenic tendency [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

4G/5G Polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome

Karadeniz

Erdoğan

Berdelı

et al. 2007

J Assist Reprod Genet

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Purpose Polycystic ovary syndrome (PCOS) is one of the most encountered endocrine malfunctions. PCOS patients have enhanced activation of the blood coagulation system. Methods Eighty-six young women with PCOS and 70 healthy control women were included in our study. PCOS patients and controls were matched for age, body mass index, and allele frequency. Genetic analysis of TPAI and PAI-1 were performed in all subjects. Results and conclusions No statistically significant differences have been detected about the ratios of genotypes resulting from PAI-1 promotor 4G/5G gene polymorphism. PAI-1 765 4G/5G gene polymorphism and TPA gene's Alurepeat insertion/deletion (I/D) polymorphism ratios were not different from the controls. In this study it is shown by the analysis of TPA gene's Alu-repeat insertion/deletion (I/D) polymorphism the PCOS patients with genotype II had lowers total cholesterol and LDL-cholesterol levels.

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Section: Discussionmentioning

confidence: 99%

4G/5G Polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome

Karadeniz

Erdoğan

Berdelı

et al. 2007

J Assist Reprod Genet

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“…DHEA is a biosynthetic precursor of virtually all steroid hormones, including testosterone and estradiol [26,27] . In the plasma, DHEA is predominantly present as DHEAS, the stored form.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Dehydroepiandrosterone on Early Pregnancy in Mice

Sander¹,

Solano²,

Elia³

et al. 2005

Neuroimmunomodulation

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The aim of the present report was to study the role of high levels of dehydroepiandrosterone (DHEA) on the ovarian function and embryonic resorption during early pregnancy in BALB/c mice. Pregnant animals were injected with DHEA following both the post-implantatory (DHEA-2) and peri-implantatory (DHEA-6) models. Morphological studies of implantation sites showed 40% of embryonic resorption in the DHEA-2 group while 100% of resorption was observed in the DHEA-6 group. Serum samples of both DHEA-2 and DHEA-6 groups showed higher estradiol levels and a lower progesterone concentration than those of control groups. Ovarian prostaglandin E levels after both DHEA-2 and DHEA-6 treatments increased when compared to control groups. The antioxidant metabolite glutathione diminished during both DHEA treatments. In summary, the data presented here suggest that DHEA treatment during early pregnancy modulates the ovarian function and is responsible for embryonic resorption with different degrees depending on when it is administered.

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“…Using a combination of clinical, ultrasonographic, and biochemical criteria, the diagnosis of PCOS is usually reserved for those women who display one or more clinical symptoms including chronic anovulation, an ultrasonographical morphology of polycystic ovaries, inappropriate gonadotropin secretion, and hyperandrogenism (Franks, 1995;Dunaif, 1997). It is reported that women with PCOS have adverse pregnancy outcome including miscarriage (Abbott et al, 2002;Doldi et al, 1998;Glueck et al, 1999;Wang et al, 2001;Diejomaoh et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Vascular Dysfunction in Women with Recurrent Pregnancy Loss

Nakastuka¹

2012

Recent Advances in Cardiovascular Risk Factors

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Polycystic ovary syndrome, infertility, familial thrombophilia, familial hypofibrinolysis, recurrent loss of in vitro fertilized embryos, and miscarriage

Cited by 58 publications

References 4 publications

4G/5G Polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome

4G/5G Polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome

The Influence of Dehydroepiandrosterone on Early Pregnancy in Mice

Vascular Dysfunction in Women with Recurrent Pregnancy Loss

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