Polycystic ovary syndrome and postpartum depression: A systematic review and meta-analysis of observational studies

Schoretsanitis, Georgios; Gastaldon, Chiara; Kalaitzopoulos, Dimitrios Rafail; Ochsenbein-Koelble, N.; Barbui, Corrado; Seifritz, Erich

doi:10.1016/j.jad.2021.12.044

Cited by 15 publications

(9 citation statements)

References 38 publications

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“…A single-center study could have some selection bias, although our unit covers a large population in northern Greece with a representative number of low-risk pregnancies. The lack of some relevant information about the history of infertility, such as the history of miscarriage, duration of infertility, and other potential confounders, is also a certain limitation [ 22 ]. Last but not least, the self-reported type of our study could also hide a recall bias.…”

Section: Discussionmentioning

confidence: 99%

Is Conception by Means In Vitro Fertilization Associated With Increased Risk of Antenatal Anxiety and Depression?

Arvanitidou¹,

Kalaitzopoulos²,

Samartzis³

et al. 2023

Cureus

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Mental health during pregnancy is a very important public health issue with negative effects on both maternal and child outcomes. The aim of our study is to examine the possible association between conception via in vitro fertilization (IVF) and anxiety or depression during the third pregnancy trimester in the Greek population during the years of financial crisis. Materials and MethodsThis single-center prospective cohort study was conducted in a tertiary university hospital during the period 2017-2018. Pregnant women attending the Antenatal Care Program between 30th-32nd gestational week were asked to complete Hamilton Anxiety Rating Scale (HAM-A) and Beck Depression Inventory (BDI). A propensity score match for 10 variables was conducted in a 1:3 ratio. ResultsOf the 521 eligible patients, 446 women were included in our study. Four hundred fourteen of them conceived spontaneously, and 32 via IVF. After propensity score matching, 76 remained in the analysis, of whom 57 conceived spontaneously and 19 with IVF. The IVF group had a higher rate of anxiety (18.8%) and a lower rate of depression (9.4%) than the spontaneous conception group (13.5% and 13.5%, respectively), but the differences were not statistically significant before and after propensity score matching. ConclusionOur study showed that pregnancies after IVF had a higher incidence of antenatal anxiety and a lower incidence of antenatal depression in comparison to pregnancies that were conceived naturally, although the differences did not reach statistical significance.

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Section: Discussionmentioning

confidence: 99%

Is Conception by Means In Vitro Fertilization Associated With Increased Risk of Antenatal Anxiety and Depression?

Arvanitidou¹,

Kalaitzopoulos²,

Samartzis³

et al. 2023

Cureus

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“…PCOS is the most common endocrine disorder in women of reproductive age with a reported prevalence varying between 6% and 10% according to the applied diagnostic criteria. 1,[4][5][6]27 The Rotterdam consensus (ESHRE/ASRM) is the most widely used PCOS diagnostic classification, which requires at least two of the following criteria for the diagnosis of PCOS: oligo-anovulation, clinical and/or biochemical hyperandrogenism, and polycystic ovary morphology (PCOM). 28 The National Institutes of Health (NIH/NICHD) criteria require both clinical and/or biochemical hyperandrogenism and chronic anovulation and androgen excess.…”

Section: Pathogenesis Of Pcosmentioning

confidence: 99%

“…[1][2][3] The principal characteristics of PCOS include hyperandrogenism, oligo-anovulation and/or polycystic ovary morphology (PCOM). [1][2][3][4][5][6] PCOS is mainly observed in women with obesity; nevertheless, there are also many lean PCOS patients. 7 The exact aetiology of PCOS remains unknown, arising from multifactorial influences, including genetic, epigenetic, and environmental factors.…”

Section: Introductionmentioning

confidence: 99%

“…Polycystic ovary syndrome (PCOS) constitutes a heterogeneous endocrinopathy, mainly affecting women of reproductive age with a prevalence varying from 5% to 20% 1–3 . The principal characteristics of PCOS include hyperandrogenism, oligo‐anovulation and/or polycystic ovary morphology (PCOM) 1–6 . PCOS is mainly observed in women with obesity; nevertheless, there are also many lean PCOS patients 7 .…”

Section: Introductionmentioning

confidence: 99%

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Cardiometabolic effects of SGLT2 inhibitors on polycystic ovary syndrome

Lempesis

Apple

Duarte

et al. 2023

Diabetes Metabolism Res

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Polycystic ovary syndrome (PCOS) is a complex endocrinopathy affecting many women of reproductive age. Although its physiology is poorly understood, hyperandrogenemia and insulin resistance play a pivotal role in this complex syndrome, predisposing patients to a variety of cardiovascular and metabolic modalities. Current therapeutic options, including lifestyle modifications and medications, often do not satisfactorily improve clinical outcomes. SGLT2 inhibitors (SGLT‐2i) are a novel option which can potentially improve many hormonal and metabolic parameters for patients with PCOS, though the net cardiovascular effects remain under investigation in this population of patients with PCOS. Overall, the use of SGLT‐2i may be associated with beneficial somatometric, metabolic and hormonal outcomes of PCOS. To date, all available studies have recorded body mass index, waist and hip circumference, and fat mass reductions, improved insulin and androgen levels, and reduced blood pressure. The aim of the present review is to summarise PCOS‐related manifestations and mechanisms leading to cardiovascular disease, to explore the cardiometabolic impact of SGLT2i on PCOS, and to critically analyse the cardiometabolic and hormonal outcomes of the recent studies on the use of SGLT2i in women with PCOS.

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“…The major clinical manifestations of PCOS consist of ovulatory dysfunction, hyperandrogenism, and polycystic ovaries, along with insulin resistance, obesity, and metabolic dysfunction (4,5). In addition, PCOS is also linked with other complications, such as type 2 diabetes, endometrial dysfunction and cancer, cardiovascular disease, depression, and pregnancy complications (6)(7)(8)(9)(10). The current standard treatment for PCOS includes lifestyle change, pharmacological therapy, and surgical modalities, but the effect is less than satisfactory (11,12).…”

Section: Introductionmentioning

confidence: 99%

Underlying mechanisms of acupuncture therapy on polycystic ovary syndrome: Evidences from animal and clinical studies

Yang

Zhou²,

Hu³

et al. 2022

Front. Endocrinol.

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Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among women of reproductive age. Current standard treatment includes lifestyle change, oral pharmacological agents, and surgical modalities. However, the efficacy of current therapies is less than satisfactory. Clinical evidence has shown that acupuncture is effective for regulating hormone levels, promoting ovulation, and attenuating insulin resistance in patients with PCOS. Acupuncture may affect the production of β‐endorphin, which may lead to gonadotropin-releasing hormone secretion and then affect ovulation, menstrual cycle, and fertility. The mechanism of acupuncture for patients with PCOS has not been comprehensively reviewed so far. Better understanding of the mechanisms of acupuncture would help popularize the use of acupuncture therapy for patients with PCOS. In this narrative review, we aimed to overview the potential mechanisms and evidence-based data of acupuncture on PCOS, and analyze the most frequently used acupoints based on animal and clinical studies. The results of this study will contribute to a better understanding of the current situation in this field.

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Polycystic ovary syndrome and postpartum depression: A systematic review and meta-analysis of observational studies

Cited by 15 publications

References 38 publications

Is Conception by Means In Vitro Fertilization Associated With Increased Risk of Antenatal Anxiety and Depression?

Is Conception by Means In Vitro Fertilization Associated With Increased Risk of Antenatal Anxiety and Depression?

Cardiometabolic effects of SGLT2 inhibitors on polycystic ovary syndrome

Underlying mechanisms of acupuncture therapy on polycystic ovary syndrome: Evidences from animal and clinical studies

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