Polycystic Ovarian Syndrome;

Abstract

Background: Polycystic ovarian syndrome is a common disease among the women in reproductive age group and morecommon in South Asian women. Clinical presentations include menstrual disorders, subfertility, obesity,hirsutism, acne vulgaris andacanthosis. Objectives: The objective of study was to investigate co relation between acne and polycystic ovaries and its relation tomenstrual irregularity. Methodology: A total of 56women were enrolled in the study from Outpatient Department of Obs&Gynae andDermatology, Dow University Hosptial, Ojha campus by convenient sampling. It was cross sectional study, conducted from July 2012 toNovember 2012.Verbal consent was taken. Sociodemographic information,Anthropometric measurement (height, weight, BMI) andacne severity with affected area, menstrual irregularities were administered on pre designed questionnaire.Pelvic ultrasound forpolycystic ovaries and serum LH, FSH in follicular phase of menstrual cycle (2nd day) advised from Dow Radiology and Dow Labrespectively. Results: A total of56 patients of PCOS were enrolled during five month period. The mean age of patient was 21.1+_SD0.994. Frequency of acne was 32 (57.1%).The mean BMI was 19.66 +_SD 4.54. Face was the commonest area involved in 24 (42.9%).menstrual irregularity was found in 50 (89.4%) women. There was no statistically significant relation seen between acne andoligomenorrhea. (X2 = 0.55 , P = 0.45). It was also determined that there was no co relation seen between the acne and serumtestosterone level calculated by independent sample t test.(P = 0.17) but statistically significant association seen between severity ofacne and serum LH/FSH ratio. (t test =3.28, p= 0.004) Conclusion: Acne was found in 32 (57.1%) women with PCOS. The study resultsrevealed a significant association seen between severity of acne and serum LH/FSH ratio. Relation between acne and serum testosteronelevel was statistically insignificant.