Polycystic liver in two adult llamas

Watanabe, Tatiane Terumi Negrão; Chaigneau, Francisco R. Carvallo; Adaska, John M.; Doncel-Díaz, Benjamín; Uzal, Francisco A.

doi:10.1177/1040638718824736

Cited by 4 publications

(2 citation statements)

References 22 publications

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“… 11 , 14 , 15 In contrast, isolated PCLD, in which only liver cysts are present, is rare, and a genetic cause remains undiscovered in cats. 1 , 4 , 6 – 8 PCLD has also been reported in hamsters, 16 llamas, 17 alpacas 18 and chamois. 19 PCLD is well characterized in hamsters; it may be associated with concurrent cysts in the epididymis, seminal vesicles, pancreas and endometrium, and in some reports has been shown to affect >75% of a population.…”

Section: Discussionmentioning

confidence: 77%

Severe polycystic liver disease in a cat

King,

Pappano,

Lorbach

et al. 2023

Journal of Feline Medicine and Surgery Open Reports

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Case summary Ductal plate malformations (DPMs) are poorly documented in the veterinary literature, particularly those of the polycystic liver disease (PCLD) phenotype. A 13-year-old female spayed cat presented with progressive icterus, abdominal distension, weight loss and elevated liver enzymes. Initial empirical treatment consisting of amoxicillin/clavulanate, ursodiol and later prednisolone was attempted; however, clinical signs progressed. On abdominal ultrasound, numerous large hepatic cystic masses were noted, characterized by an anechoic center with a heterogeneous, hyperechoic wall. A post-mortem examination confirmed numerous hepatic cysts, the larger of which resulted in hemorrhage and subsequent hemoabdomen. Histologically, these cysts were determined to be of biliary origin, and a diagnosis of PCLD was assigned. Relevance and novel information Herein, we present a detailed report of clinical, gross and histologic findings in a cat clinically affected by PCLD. This case demonstrates that cysts present in this congenital disease can ultimately lead to hepatobiliary malfunction and clinical decline via marked expansion of cysts, compression of the liver and hemoabdomen from cyst rupture. DPMs, specifically PCLD, should be considered in cats presenting with multifocal large hepatic cysts.

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Section: Discussionmentioning

confidence: 77%

Severe polycystic liver disease in a cat

King,

Pappano,

Lorbach

et al. 2023

Journal of Feline Medicine and Surgery Open Reports

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“…In addition to the benign and proliferative lesions previously discussed, there were a number of non-neoplastic proliferative lesions diagnosed in the CSU-VDL submissions and in the literature including polyps; hamartomas; bone cysts; polycystic liver; cystic rete testes; and thyroid, adrenocortical, lobular mammary, and endometrial hyperplasia (5,15,(78)(79)(80)(81)(82)(83).…”

Section: Other Non-neoplastic Proliferative Lesionsmentioning

confidence: 99%

Neoplasia and Proliferative Lesions of New World Camelids: A Systematic Literature Review and Retrospective Study of Cases Submitted to Colorado State University From 1995 to 2020

et al. 2021

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Camelid pathology submissions to veterinary diagnostic laboratories are on the rise given the increasing popularity and population of llamas and alpacas especially in the western United States. When compared to other animals, the field of camelid neoplasia has a relative paucity of cases reported in the literature. The Colorado State University Veterinary Diagnostic Laboratories (CSU-VDL) has had a steady increase in the numbers of camelid pathology submissions allowing for a robust review of diagnoses of neoplasia in new world camelids. Here we present a retrospective analysis of camelid neoplastic and proliferative lesions diagnosed at the CSU-VDL from 1995 to 2020, followed by an extensive literature review. Results show increasing incidence of camelid neoplasia reported in the literature, therefore becoming a common diagnosis in llamas and alpacas. Proliferative and neoplastic lesions were diagnosed in 8.8% of new world camelid submissions to CSU-VDL with the most common tumors being lymphomas, squamous cell carcinomas, fibromas, and adenocarcinomas. Risk factors are female sex and increased age except in the case of lymphoma, which tends to occur in younger camelids. Lymphomas, melanomas, and adenocarcinomas (especially of gastrointestinal tract) carry an increased risk of multiple-organ system involvement often with widespread metastases. Conditions described in camelids for the first time include osteosarcoma, cutaneous hemangiosarcoma, myxosarcoma, pilomatricoma, ovarian theca cell tumor, congenital nevus with malignant transformation, and various other neoplasia. This article will provide an operational guide for camelid neoplasia to further assist veterinary laboratory diagnosticians, researchers, and practicing veterinarians in the field of camelid medicine and pathology.

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Digestive System and Abdomen

Niehaus¹,

Mora²

2022

Medicine and Surgery of Camelids

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Polycystic liver in two adult llamas

Cited by 4 publications

References 22 publications

Severe polycystic liver disease in a cat

Severe polycystic liver disease in a cat

Neoplasia and Proliferative Lesions of New World Camelids: A Systematic Literature Review and Retrospective Study of Cases Submitted to Colorado State University From 1995 to 2020

Digestive System and Abdomen

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