Polycystic Kidney Disease Is a Risk Factor for New-Onset Diabetes After Transplantation

Hamer, Rizwan; Chow, Chern L; Ong, Albert; McKane, William

doi:10.1097/01.tp.0000248759.37146.3d

Cited by 93 publications

(51 citation statements)

References 16 publications

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“…18,19 However, corticosteroids, with their dose-dependent effect to stimulate insulin resistance, are associated with the highest risk of PTDM. 19,20 The drug regimen administered to both study groups was comparable, including steroid administration, therefore it seems that medication factor did not influenced the study results. The present study revealed a significant association between PTDM and CAPN10 gene SNP-63 (rs5030952:C4T) polymorphism, as well as 1-1-2 haplotype (derived from SNP-43 (rs3792267), SNP-19 (rs3842570) and SNP-63 (rs5030952)).…”

Section: Discussionmentioning

confidence: 99%

Association of calpain-10 gene polymorphism and posttransplant diabetes mellitus in kidney transplant patients medicated with tacrolimus

Kurzawski

Dziewanowski²,

Kędzierska

et al. 2009

Pharmacogenomics J

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New-onset, posttransplant diabetes mellitus (PTDM) has a high incidence after kidney transplantation in patients medicated with tacrolimus, and may adversely affect the patient and graft survival. The pathophysiology of PTDM closely mimics that of type II diabetes mellitus (T2DM). One of possible genetic factors predisposing to PTDM might be polymorphism in calpain-10 gene (CAPN10), previously associated with increased risk of T2DM in general population. Therefore, the present study was aimed at evaluation of CAPN10 gene polymorphisms in PTDM in kidney transplant patients medicated with tacrolimus. A total of 214 nondiabetic kidney transplant patients medicated with tacrolimus (56 patients with PTDM and 158 patients without PTDM were genotyped for the presence of CAPN10 gene variants (SNP-43: rs3792267:G4A, SNP-19: rs3842570 ins/del and SNP-63: rs5030952:C4T) using PCR-based assays. Frequency of SNP-63 minor allele was slightly increased in PTDM patients (P ¼ 0.056), and an association of SNP-63 heterozygosity and the risk of PTDM (odds ratios (OR) ¼ 2.45, P ¼ 0.023) was observed. An increased odds for PTDM development in patients carrying 1-1-2 haplotype (rs3792267:G-rs3842570:ins-rs5030952:T) compared to noncarriers was also noted (OR ¼ 2.35, P ¼ 0.026). Patients' higher body mass index and SNP-63 minor T allele carrier status were identified as independent PTDM risk factors, confirmed by multivariate regression analysis. This is the first study of CAPN10 polymorphism in relation to PTDM risk. However, the application of SNP-63 (rs5030952:C4T) as a marker of PTDM should be verified by further independent studies.

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Section: Discussionmentioning

confidence: 99%

Association of calpain-10 gene polymorphism and posttransplant diabetes mellitus in kidney transplant patients medicated with tacrolimus

Kurzawski

Dziewanowski²,

Kędzierska

et al. 2009

Pharmacogenomics J

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“…17 However, several other risk factors such as age, pre-transplant weight, certain infections and genetic predisposition have also been identified or suggested. [18][19][20][21][22][23] To the best of our knowledge, the role of hyperparathyroidism in developing NODAT has not been studied. This association could have important implications in the assessment of the individual patient risk of NODAT and in how to handle hyperparathyroidism in transplanted patients.…”

Section: Introductionmentioning

confidence: 99%

Hyperparathyroidism and New Onset Diabetes After Renal Transplantation

Ivarsson¹,

Clyne²,

Almquist³

et al. 2014

Transplantation Proceedings

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Hyperparathyroidism and new onset diabetes after renal transplantation.Ivarsson, Kerstin; Clyne, Naomi; Almquist, Martin; Akaberi, Shahriar General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. (21) AbstractHyperparathyroidism and New Onset Diabetes after Renal TransplantationBackground: Secondary hyperparathyroidism (sHPT) persists after renal transplantation in a

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“…15 However a threefold increased risk of developing new-onset diabetes after transplantation in ADPKD has recently been reported. 19 …”

Section: Chronic Kidney Disease and Renal Replacement Therapymentioning

confidence: 99%

Autosomal dominant polycystic kidney disease

Chow

Ong

2009

Clinical Medicine

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Polycystic Kidney Disease Is a Risk Factor for New-Onset Diabetes After Transplantation

Abstract: We conclude that ADPKD is a significant risk factor for the development of NODAT. This may influence the follow up and management choices of these patients in the future.

Cited by 93 publications

References 16 publications

Association of calpain-10 gene polymorphism and posttransplant diabetes mellitus in kidney transplant patients medicated with tacrolimus

Association of calpain-10 gene polymorphism and posttransplant diabetes mellitus in kidney transplant patients medicated with tacrolimus

Hyperparathyroidism and New Onset Diabetes After Renal Transplantation

Autosomal dominant polycystic kidney disease

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