Polycomb repression in the regulation of growth and development in Arabidopsis

Xiao, Jun; Wagner, Doris

doi:10.1016/j.pbi.2014.10.003

Cited by 153 publications

(115 citation statements)

References 113 publications

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“…While chromatin states are a critical part of transcriptional responses during development (reviewed in He et al, 2011;Holec and Berger, 2012;Grimanelli and Roudier, 2013;Pikaard and Mittelsten Scheid, 2014;Xiao and Wagner, 2015) or in response to the environment (reviewed in Baulcombe and Dean, 2014;Bond and Baulcombe, 2014;Pikaard and Mittelsten Scheid, 2014;Probst and Mittelsten Scheid, 2015;Vriet et al, 2015), they also play critical roles in creating order in the genome, allowing for the maintenance of proper transcription and genome stability in the face of varying TE landscapes and polyploid changes. We suggest that diverse plant species have evolved variations in the specific mechanisms of chromatin regulation that have allowed them to survive the repeated transposon bursts or polyploidy fusions.…”

Section: Resultsmentioning

confidence: 99%

“…In some cases, chromatin modifiers are likely to be recruited to achieve and stabilize alterations in transcription. Several recent reviews have provided excellent summaries of these activities and point toward the conservation of these pathways among flowering plants (Baulcombe and Dean, 2014;Bond and Baulcombe, 2014;Pikaard and Mittelsten Scheid, 2014;Probst and Mittelsten Scheid, 2015;Vriet et al, 2015;Xiao and Wagner, 2015). In this Review, we focus on aspects of chromatin regulation that might be variable or drive variation among closely related species.…”

Section: Introductionmentioning

confidence: 99%

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Creating Order from Chaos: Epigenome Dynamics in Plants with Complex Genomes

Springer

Lisch

2016

Plant Cell

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ORCID IDs: 0000-0002-7301-4759 (N.M.S.); 0000-0003-3232-9479 (Q.L.)Flowering plants have strikingly distinct genomes, although they contain a similar suite of expressed genes. The diversity of genome structures and organization is largely due to variation in transposable elements (TEs) and whole-genome duplication (WGD) events. We review evidence that chromatin modifications and epigenetic regulation are intimately associated with TEs and likely play a role in mediating the effects of WGDs. We hypothesize that the current structure of a genome is the result of various TE bursts and WGDs and it is likely that the silencing mechanisms and the chromatin structure of a genome have been shaped by these events. This suggests that the specific mechanisms targeting chromatin modifications and epigenomic patterns may vary among different species. Many crop species have likely evolved chromatin-based mechanisms to tolerate silenced TEs near actively expressed genes. These interactions of heterochromatin and euchromatin are likely to have important roles in modulating gene expression and variability within species.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Creating Order from Chaos: Epigenome Dynamics in Plants with Complex Genomes

Springer

Lisch

2016

Plant Cell

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“…As PcG function is involved in the repression of master regulatory genes (Xiao and Wagner, 2015), misregulation in the different atbmi1 mutants may be an indirect or direct consequence of the loss of AtBMI1 function, or a mix of both. Conversely, a considerable number of AtBMI1 direct target genes may not display altered expression in the absence of their upstream transcriptional activators, as has been reported for other PcG loss of function mutants (Bouyer et al, 2011;Kim et al, 2012;Derkacheva et al, 2013).…”

Section: Genome-wide Transcriptomic Data Analysis Of Atbmi1 Mutantsmentioning

confidence: 99%

The Arabidopsis Polycomb Repressive Complex 1 (PRC1) Components AtBMI1A, B, and C Impact Gene Networks throughout All Stages of Plant Development

et al. 2016

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Polycomb Group regulation in Arabidopsis (Arabidopsis thaliana) is required to maintain cell differentiation and allow developmental phase transitions. This is achieved by the activity of three PcG repressive complex 2s (PRC2s) and the participation of a yet poorly defined PRC1. Previous results showed that apparent PRC1 components perform discrete roles during plant development, suggesting the existence of PRC1 variants; however, it is not clear in how many processes these components participate. We show that AtBMI1 proteins are required to promote all developmental phase transitions and to control cell proliferation during organ growth and development, expanding their proposed range of action. While AtBMI1 function during germination is closely linked to B3 domain transcription factors VAL1/2 possibly in combination with GT-box binding factors, other AtBMI1 regulatory networks require participation of different factor combinations. Conversely, EMF1 and LHP1 bind many H3K27me3 positive genes up-regulated in atbmi1a/b/c mutants; however, loss of their function affects expression of a different subset, suggesting that even if EMF1, LHP1, and AtBMI1 exist in a common PRC1 variant, their role in repression depends on the functional context.

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“…They are subject to a vast array of posttranslational modifications that can occur alone or in a combinatorial fashion known as the histone code, which dictates DNA accessibility and genome function (Rothbart and Strahl, 2014). The language of histone modifications is exemplified in Polycomb (Pc) silencing, a major epigenetic mechanism conserved in both animals and plants (Simon and Kingston, 2013;de la Paz Sanchez et al, 2015;Mozgova and Hennig, 2015;Xiao and Wagner, 2015). Polycomb Group (PcG) proteins, originally identified in Drosophila spp.…”

mentioning

confidence: 99%