Polychromatic LED in Oval Full-Thickness Wound Healing in Non-diabetic and Diabetic Rats

Al-Watban, Farouk A.H.; Andres, Bernard L.

doi:10.1089/pho.2006.24.10

Cited by 33 publications

(21 citation statements)

References 11 publications

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“…However, there are no studies in the literature using LED light on wound healing in hypothyroid rats. Several studies, both in vitro and in vivo, have shown that LED phototherapy influences tissue repair [9,[12][13][14][15][16][17] and consists in an alternative for the treatment of both cutaneous and mucosal wounds [15,18], but we do not yet have a full understanding of the mechanisms involved in this process. It seems that the LED light treatment (630-1000nm) stimulates the photoacceptor cytochrome c oxidase and the mitochondrial metabolism, resulting in increased energy metabolism and production of adenosine triphosphate (ATP) by target cells, such as increased collagen synthesis by fibroblasts, accelerating tissue repair [10,11,16,19,20].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of LED photobiomodulation on wound healing in hypothyroid and euthyroid rats

Paraguassú¹,

Xavier²,

Rodriguez³

et al. 2012

AIP Conference Proceedings

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Articles you may be interested inAssessment of the effects of laser or LED photobiomodulation on hypothyroid rats of cutaneous wound healing: A morphometric study.Evaluation of the effect of LED radiation in the repair of skin wounds on the dorsum of rats with iron deficiency anemia AIP Conf.Abstract. Thyroid hormone deficiency has been associated to disruption of the body's metabolism, including healing process. LED phototherapy has been shown to be effective in improving healing in many situations, but their usefulness in the improvement of hypothyroidism wound healing remains unknown. The aim of this study was to assess histologically the effect of LED (λ630 ± 20nm, 150mW, CW, φ=0.5 cm², 24J/cm² per session) on wounds healing in hypothyroid and euthyroid Wistar rats. Standard cutaneous wound (1cm²) was created on the dorsum of 24 animals divided into four groups of 6 animals each: G1: Euthyroid; G2: Euthyroid + LED; G3: Hypothyroid; G4: Hypothyroid + LED. Hypothyroidism was induced in rats with propylthiouracil (0.05g/100mL) administered orally for 4 weeks and maintained until the end of the experiment. The irradiation started immediately after surgery and was repeated every other day for 7 days. Animals were killed 8 days after surgery. The specimens were removed, routinely processed and stained with H&E and Sirius red. Statistical analysis was performed using the Fisher´s Test and significance level was 5%. The results of the present investigation showed delayed wounds healing process in hypothyroid rats characterized by incomplete reepithelialization and formation of disorganized collagen fibers (p<0.05) when compared to the euthyroid group, and that in the irradiated groups the reepithelialization was statistically higher when compared with non-irradiated ones (p<0.05). There was improved collagen fibers deposition on irradiated animals (euthyroid and hypothyroid) when compared to non-irradiated ones, but no statistically significant difference (p>0.05). It is concluded that LED light has a positive biomodulative effect on the wound healing process, even when hipothyroidism was present.

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Section: Discussionmentioning

confidence: 99%

Evaluation of LED photobiomodulation on wound healing in hypothyroid and euthyroid rats

Paraguassú¹,

Xavier²,

Rodriguez³

et al. 2012

AIP Conference Proceedings

View full text Add to dashboard Cite

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“…One potential candidate is the light-emitting diode (LED) light source which has the advantages of portability, high luminance, a relatively narrow spectrum, long lifespan, and low cost. In fact, LEDs in the visible spectrum have been applied to phototherapy in several other skin diseases such as wound healing, 21 acne, 22 and photodynamic therapy. 23 In this study, we tested the efficacy of UV-A1 LEDs in treating hypertrophic scar on rabbit ear.…”

Section: Introductionmentioning

confidence: 99%

Portable ultraviolet light A1 light source to treat hypertrophic scar

Huang

et al. 2015

Dermatologica Sinica

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a b s t r a c tBackground/Objectives: Recently, fibrotic diseases such as hypertrophic scar, keloid, and scleroderma have been treated with UV-A1 radiation with encouraging results. However, conventional UV light sources are bulky and expensive. In this study, we aimed to verify the effectiveness of a portable UV-A1 radiation device in treating hypertrophic scars. Materials and methods: A light-emitting diode array that emitted 365 ± 5 nm (UV-A1) was used to irradiate fibroblasts and hypertrophic scar in a rabbit model. Results: In cell cultures, UV-A1 light exposure inhibited post-wound cell migration and reduced the total amount of soluble collagen production in fibroblasts. Type I collagenase production and its activity increased after treatment. On the rabbit ear, UV-A1 light irradiation reduced the thickness of hypertrophic scars, confirming the antifibrotic effect in vivo. Conclusion: These results support the potential of a portable UV-A1 light device in treating hypertrophic scar.

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“…[1][2][3][4][5][6] However, we do not yet have a full understanding of the mechanisms involved in this.…”

Section: Introductionmentioning

confidence: 99%

“…17 It seems possible that LEDPT presents beneficial effects similar to the ones observed when LPT is used, as several reports on the benefits of the use of LEDs operating at several wavelengths, both in vitro and in vivo, in both normal and pathologic conditions, have been published elsewhere. 2,3,6,[18][19][20][21][22][23][24][25] It is also possible that the mechanism involved is similar.…”

Section: Introductionmentioning

confidence: 99%

Effect of LED Phototherapy (λ700 ± 20 nm) on TGF-β Expression During Wound Healing: An Immunohistochemical Study in a Rodent Model

Sousa

Neto²,

Marchionni³

et al. 2011

Photomedicine and Laser Surgery

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Polychromatic LED in Oval Full-Thickness Wound Healing in Non-diabetic and Diabetic Rats

Abstract: The effect of polychromatic LED therapy in oval full-thickness wound-healing in the diabetic model with the use of 5 and 10 J/cm(2) is promising. Further studies to determine optimum dosimetry and efficacy of LEDs are recommended.

Cited by 33 publications

References 11 publications

Evaluation of LED photobiomodulation on wound healing in hypothyroid and euthyroid rats

Evaluation of LED photobiomodulation on wound healing in hypothyroid and euthyroid rats

Portable ultraviolet light A1 light source to treat hypertrophic scar

Effect of LED Phototherapy (λ700 ± 20 nm) on TGF-β Expression During Wound Healing: An Immunohistochemical Study in a Rodent Model

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