Polychlorinated biphenyl levels in adipose tissue of primiparous women in Turkey

Çok, İsmet; Şatiroğlu, M. Hakan

doi:10.1016/s0160-4120(03)00140-5

Cited by 31 publications

(4 citation statements)

References 22 publications

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“…Bien que l'efficacité insecticide de la totalité des isomères de l'hexachlorocyclohexane ne soit pas établie, des mixtures techniques renfermant l'ensemble de ces composés ont été commercialisées au travers le monde [4]. Au-delà de leur effet contaminant de l'environnement via l'usage agricole, les BPCs continuent à persister, puisqu'ils sont utilisés dans différents secteurs industriels, tels que la fabrication des transformateurs et conducteurs électriques, ou encore les lubrifiants hydrauliques [5,6].…”

Section: Introductionunclassified

Effet de l'hexachlorobenzène sur certains paramètres de la fonction de reproduction mâle chez Meriones unguiculatus

Bitri¹,

Darragi²,

Ouertani³

et al. 2008

Comptes Rendus. Biologies

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Les pesticides organochlorés, considérés comme contaminants environnementaux, sont connus pour induire des perturbations d'un certain nombre de fonctions physiologiques dont la fonction de reproduction. L'impact de l'hexachlorobenzène (HCB) sur la fonction de reproduction mâle chez Meriones unguiculatus a été étudié sur trois lots d'animaux recevant par gavage quotidien 1,6, 4 et 16 mg/kg PC/j pendant 30 j. Sur un plan macroscopique, le HCB entraîne une diminution significative du poids relatif testiculaire, alors que le poids relatif des vésicules séminales ne semble pas être affecté par le traitement. L'étude cytoarchitecturale montre qualitativement une diminution du nombre de spermatozoïdes, suggérant une modification du déroulement de la spermatogenèse et une perturbation de la phase de différentiation particulièrement visible avec la dose la plus forte. L'état de l'activité testiculaire a été estimé par une détermination morphométrique du diamètre des tubes séminifères et par la quantification de l'activité spermatique. Aucune modification significative du diamètre des tubes séminifères n'est observée ; en revanche, l'activité spermatique des testicules des animaux traités avec 16 mg/kg/j est significativement affectée : elle passe de 88 ± 4,89% chez les animaux témoins à 60 ± 3,16%, soit une diminution de l'ordre de 32%. Sur le plan endocrinien, une diminution significative de la testostéronémie est observée chez les animaux des lots II et III (respectivement 0,48 ± 0,08 ng/ml et 0,54 ± 0,07 ng/ml) comparativement à ceux du lot témoin (1,08 ± 0,1 ng/ml), p < 0.01.

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Section: Introductionunclassified

Effet de l'hexachlorobenzène sur certains paramètres de la fonction de reproduction mâle chez Meriones unguiculatus

Bitri¹,

Darragi²,

Ouertani³

et al. 2008

Comptes Rendus. Biologies

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“…Although limited studies conducted in Turkey has reported the presence of PCB compounds in human, environment, and food. Cok et al reported in the first study aiming the investigation of PCBs in humans that the indicator PCBs were present in both milk and adipose tissues of women (Cok et al 2003;Cok and Satiroglu 2004). The same group also reported the first results about men dioxin-like PCB levels in adipose tissue of Turkish men (Cok et al 2007).…”

Section: Resultsmentioning

confidence: 95%

Determination of organochlorine pesticide and polychlorinated biphenyl levels in adipose tissue of infertile men

Çok

Durmaz

et al. 2009

Environ Monit Assess

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During the recent two decades, a remarkable drop in fertility rates has been noticed almost all over the world. A series of studies have showed that environmental factors had the primary role causing the observed adverse trends in the male reproductive health problems. Especially chlorinated hydrocarbons, for instance polychlorinated biphenyls (PCB) and pesticides, could mimic or antagonize the effects of steroid hormones, like estrogens and androgens and possibly interfering with male reproductive capacity. Organochlorine pesticides (OCPs) (i.e. p.p'-DDT, endosulfan...) and PCBs are widespread used chemicals in agriculture and industry for different purposes all over the world. Although direct evidence is lacking, theoretical considerations and epidemiological evidence implicate these compounds as potential hazards to human and wildlife reproductive health. For this purpose, in this study adipose tissue samples have provided from healthy males which were diagnosed as infertile men living in Ankara, Turkey at least for 5 years. Residual levels of OCPs (alpha-BHC, beta-BHC, gamma-BHC, HCB, Endosulfan I, II, p,p'-DDE, and p,p'-DDT) and seven major persistent PCB congeners (PCB 28, 52, 101, 118, 138, 153, and 180) were measured in 25 infertile men and 21 healthy men's adipose tissue samples by GC-ECD. Levels of OCPs and PCBs in adipose tissue of infertile men compared with those provided from controls. When the concentrations of each of the OCP were compared between the fertile and infertile groups, no statistical significance was obtained. Concentrations of each of the PCB congeners were compared between the fertile and infertile groups, no statistical significance was obtained (p > 0.05), except for 2,2',5,5'-Tetrachlorobiphenyl (PCB 52) (p = 0.032) and 2,2',3,4,4',5,5'-heptachlorobiphenyl (PCB 180) (p = 0.017).

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“…These compounds may produce immune, oxidative and genotoxic effects in aquatic organisms of different trophic levels, such as bivalves, crabs and fishes (Orbea et al, 2002;van der Oost et al, 2003). In humans, for example, these compounds have been linked with adverse health alterations, including skin lesions, neuro and immunotoxicity, endocrine disruption, carcinogenicity and chronic reproductive effects, with an increasing risk of infertility (Çok and Şartiroğlu, 2004;Jaikanlaya et al, 2009;Meeker and Hauser, 2010). Thus, it is crucial to understand the mechanisms underlying bioaccumulation and detoxification of the marine fauna, particularly of species playing key role in the ecosystems 0 structure and functioning and simultaneously with great socio-economic interest, like the edible shrimp P. varians.…”

Section: Discussionmentioning

confidence: 99%

Uptake and depuration of PCB-153 in edible shrimp Palaemonetes varians and human health risk assessment

Grilo

Cardoso

Pato

et al. 2014

Ecotoxicology and Environmental Safety

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a b s t r a c tA medium-term mesocosm exposure study was conducted to elucidate bioaccumulation and depuration of polychlorinated biphenyl congener 153 (PCB-153) in edible shrimp Palaemonetes varians. Over the 15-day exposure period, shrimp under different exposure concentrations exhibited a significant increase in PCB-153 concentration compared with control organisms. Distinct bioaccumulation patterns and uptake rates were observed depending on the exposure concentrations. For low PCB-153 exposure levels ), accumulation was faster and linear. In addition, the bioaccumulation rate was not proportional to PCB-153 concentration, and the bioaccumulation was higher at intermediate exposure concentrations. Regarding the depuration phase, P. varians lost up to 30% of PCB-153 after 72 h and levels continued slowly to decrease until the end of the 30-d experimental period. However, PCB-153 levels in shrimp did not reach background values, and those exposed to moderate and high PCB-153 concentrations presented contamination levels much higher than the regulatory limit for human food consumption (75 ng g À 1 ww for Σ 6 PCB).

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Polychlorinated biphenyl levels in adipose tissue of primiparous women in Turkey

Cited by 31 publications

References 22 publications

Effet de l'hexachlorobenzène sur certains paramètres de la fonction de reproduction mâle chez Meriones unguiculatus

Effet de l'hexachlorobenzène sur certains paramètres de la fonction de reproduction mâle chez Meriones unguiculatus

Determination of organochlorine pesticide and polychlorinated biphenyl levels in adipose tissue of infertile men

Uptake and depuration of PCB-153 in edible shrimp Palaemonetes varians and human health risk assessment

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