Polychlorinated Biphenyl Congeners as Markers of Toxic Equivalents of Polychlorinated Biphenyls, Dibenzo-p-dioxins and Dibenzofurans in Breast Milk

Glynn, Anders; Atuma, Samuel; Aune, Marie; Darnerud, Per Ola; Cnattingius, Sven

doi:10.1006/enrs.2001.4270

Cited by 46 publications

(24 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, the results were similar to our previous analysis of breast milk PCBs, p,p 0 -DDT, p,p 0 -DDE, and HCH levels, in which the contamination levels in the two cities were comparable, although they were higher in the Guangzhou populations (Wong et al, 2002). In other countries, the detectable dioxin concentrations, in terms of chemical-TEQ (C-TEQ), have been 9.6-35 pg/g fat (PCDD/ PCDF) in Sweden (Glynn et al, 2001), 9.9-48.5 pg/g fat (PCDD/PCDF/CoPCB) in Japan (Nakagawa et al, 1999), 16-40.2 pg/g fat (PCDD/PCDF) in the Republic of Uzbekistan (Ataniyazova et al, 2001), 21-53 pg/g fat (PCDD/PCDF) in agricultural regions of southern Kazakhstan (Hooper et al, 1999), and 5.9-17.1 pg/g fat (PCDD/PCDF) in Spain (Schuhmacher et al, 1999). Despite the results indicated above, EROD-TEQ and C-TEQ analyses have particular pros and cons, and thus caution should be taken in when interpreting the data.…”

Section: Article In Presssupporting

confidence: 47%

“…Hence, numerous studies have tried to develop a more costefficient assessment of dioxin exposure. Most studies have adopted the use of PCB congeners in breast milk as markers for dioxin measurement (Glynn et al, 2001;Koopman-Essebom et al, 1994). However, the association between concentrations of PCB markers and dioxin may vary among individual study populations with different geographical and cultural backgrounds.…”

Section: Introductionmentioning

confidence: 99%

“…However, the association between concentrations of PCB markers and dioxin may vary among individual study populations with different geographical and cultural backgrounds. The underestimation of actual dioxin concentrations using PCB markers has been reported (Atuma et al, 1998;Glynn et al, 2001). Nevertheless, there is still an intrinsic limitation to the chemical analysis for describing the possible biological and toxicological effects of dioxin in animals.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dioxin-like components in human breast milk collected from Hong Kong and Guangzhou

Lai¹,

Li²,

Xu³

et al. 2004

Environmental Research

View full text Add to dashboard Cite

Section: Article In Presssupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dioxin-like components in human breast milk collected from Hong Kong and Guangzhou

Lai¹,

Li²,

Xu³

et al. 2004

Environmental Research

View full text Add to dashboard Cite

“…Congeners CB 105, CB 118, CB 156, and CB 167 were chosen to represent mono-ortho PCBs with dioxin-like activity ( Van den Berg et al 1998). Of these, CB 167 gives a low contribution to the concentrations of dioxin toxic equivalents (TEQs), but a previous study indicated that this congener may be used as a marker of TEQ body burden in Swedish women (Glynn et al 2001). Among the congeners with no reported dioxin-like activity in vivo, the diortho congeners CB 138, CB 153, and CB 180 were chosen because they are present at high concentrations in Swedish food Glynn et al, 2000b) and are included in the PCB regulation in several European countries.…”

Section: Methodsmentioning

confidence: 99%

Organochlorines in Swedish women: determinants of serum concentrations.

Glynn

Granath

Aune

et al. 2003

Environ Health Perspect

Self Cite

173

View full text Add to dashboard Cite

We studied associations between lifestyle/medical factors and lipid-adjusted serum concentrations of seven polychlorinated biphenyl (PCB) congeners and five chlorinated pesticides/metabolites among 205 Swedish women (54-75 years old). Serum concentrations were significantly associated with age, body mass index, body weight change, diabetes mellitus, consumption of fatty fish, and place of residence. The findings suggest that lifestyle/medical factors may confound results in epidemiologic studies when they are related to both serum concentrations and disease. Moreover, disease itself may influence serum concentrations of some organochlorines, as indicated by the negative associations between recent weight change and serum concentrations of some PCB congeners, p,p -dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) and the positive association between diabetes mellitus and HCB concentrations. Age was the only determinant that showed a consistent association with all compounds studied (positive); otherwise associations with single determinants varied among compounds even within the PCB group. This shows that the studied organochlorines should not be treated as a homogeneous group of compounds in epidemiologic studies.

show abstract

“…Because humans are generally exposed to similar mixtures, the patterns seen in different individuals tend to have many similarities. Previous investigations, many involving limited numbers of congeners or relatively small populations, have shown that concentrations of certain congeners in humans are positively correlated, with some of the correlations being quite high (DeVoto et al 1997;Gladen et al 1999a;Glynn et al 2000Glynn et al , 2001Longnecker et al 2000;van den Berg et al 1995). To the extent that high correlations exist among congeners, there is both no need to measure them separately and no ability to distinguish their biologic effects.…”

mentioning

confidence: 99%

Assessing human polychlorinated biphenyl contamination for epidemiologic studies: lessons from patterns of congener concentrations in Canadians in 1992.

Gladen

Doucet

Hansen

2003

Environ Health Perspect

View full text Add to dashboard Cite

Humans are always exposed to mixtures of polychlorinated biphenyls (PCBs), so assessment of their health effects is complicated. Because the original sources are relatively standard mixtures that change in predictable ways while traversing the environment, there is substantial uniformity in the congener mixtures people carry. To the extent that concentrations are highly correlated, measuring multiple congeners within correlated groups would be unnecessary and estimation of separate biologic effects would be impossible. We examined correlation patterns in previously collected data on 38 congeners (and 14 other organochlorines) from 497 human milk samples from Canada from 1992. Congeners 138, 153, 156, 157, 170, 183, 187, 194, 199, and 203 were highly intercorrelated; 180 had slightly lower correlations with this group. Congeners 74, 105, and 118 were highly intercorrelated and moderately to highly correlated with the first group. Congener 99 had moderate correlations with both these groups, and congener 66 had lesser correlations with the primary group. In contrast, congeners 28, 44, 49, 60, 90/101, 128, 137, and 193 showed little correlation with any other congeners. The remaining 14 congeners were uninformative; they were quantified in fewer than 30% of samples, and varying lipid concentrations meant that those quantified were not necessarily at higher concentrations than those not quantified. In study of human health effects of PCBs, the congener pattern present in the population under study should be examined when deciding which congeners to measure; instead of solely redundant or uninformative congeners, attention should be given to other congeners that may be more useful in addressing the question of interest.

show abstract

Polychlorinated Biphenyl Congeners as Markers of Toxic Equivalents of Polychlorinated Biphenyls, Dibenzo-p-dioxins and Dibenzofurans in Breast Milk

Cited by 46 publications

References 27 publications

Dioxin-like components in human breast milk collected from Hong Kong and Guangzhou

Dioxin-like components in human breast milk collected from Hong Kong and Guangzhou

Organochlorines in Swedish women: determinants of serum concentrations.

Assessing human polychlorinated biphenyl contamination for epidemiologic studies: lessons from patterns of congener concentrations in Canadians in 1992.

Contact Info

Product

Resources

About