Polycationic nanoparticles synthesized using ARGET ATRP for drug delivery

Forbes, Diane C.; Creixell, Mar; Frizzell, Hannah; Peppas, Nicholas A.

doi:10.1016/j.ejpb.2013.01.007

Cited by 31 publications

(28 citation statements)

References 28 publications

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“…These size values are also in accordance with published studies on pH-responsive acrylic-based polymer nanospheres. 17 Zeta potential values increased as well to near 0 mV due to surface charge neutralization, which led to poor colloidal stability of the suspension and difficulty for the measure of particles 32 at pH values lower than 3 (data not shown).…”

Section: Resultsmentioning

confidence: 99%

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Surface-Modified P(HEMA-co-MAA) Nanogel Carriers for Oral Vaccine Delivery: Design, Characterization, and In Vitro Targeting Evaluation

et al. 2014

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Oral drug delivery is a route of choice for vaccine administration because of its noninvasive nature and thus efforts have focused on efficient delivery of vaccine antigens to mucosal sites. An effective oral vaccine delivery system must protect the antigen from degradation upon mucosal delivery, penetrate mucosal barriers, and control the release of the antigen and costimulatory and immunomodulatory agents to specific immune cells (i.e., APCs). In this paper, mannan-modified pH-responsive P(HEMA-co-MAA) nanogels were synthesized and assessed as carriers for oral vaccination. The nanogels showed pH-sensitive properties, entrapping and protecting the loaded cargo at low pH values, and triggered protein release after switching to intestinal pH values. Surface decoration with mannan as carbohydrate moieties resulted in enhanced internalization by macrophages as well as increasing the expression of relevant costimulatory molecules. These findings indicate that mannan-modified P(HEMA-co-MAA) nanogels are a promising approach to a more efficacious oral vaccination regimen.

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Section: Resultsmentioning

confidence: 99%

“…32 Cultures were maintained in T-75 flasks (Corning, Corning, NY) at 37 °C in a humidified environment of 5% CO 2 (Sheldon Signature HEPA Clean CO 2 incubator, VWR). The medium was replaced every other day, and the cells were routinely passaged at 80% confluence.…”

Section: Methodsmentioning

confidence: 99%

Surface-Modified P(HEMA-co-MAA) Nanogel Carriers for Oral Vaccine Delivery: Design, Characterization, and In Vitro Targeting Evaluation

et al. 2014

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“…, the inclusion of TBMA and TBAEMA, resulted in a decreased onset of pH-dependent gel swelling, while the TBMA depressed the critical swelling pH from 7.8 to 7.0 [108]. Forbes et al were able to exhibit tighter control of final cationic nanogel parameters by switching from a UV-initiated polymerization to ARGET-ATRP initiated polymerization [109,110]. Furthermore, these cationic nanogels were able to be successfully complexed with siRNA, and promote cellular uptake in RAW264.7 macrophages and HEK293T cells [66,110].…”

Section: Ph-responsive Hydrogelsmentioning

confidence: 99%

Stimulus-responsive hydrogels: Theory, modern advances, and applications

Koetting

Peters

Steichen

et al. 2015

Materials Science and Engineering: R: Reports

866

688

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Over the past century, hydrogels have emerged as effective materials for an immense variety of applications. The unique network structure of hydrogels enables very high levels of hydrophilicity and biocompatibility, while at the same time exhibiting the soft physical properties associated with living tissue, making them ideal biomaterials. Stimulus-responsive hydrogels have been especially impactful, allowing for unprecedented levels of control over material properties in response to external cues. This enhanced control has enabled groundbreaking advances in healthcare, allowing for more effective treatment of a vast array of diseases and improved approaches for tissue engineering and wound healing. In this extensive review, we identify and discuss the multitude of response modalities that have been developed, including temperature, pH, chemical, light, electro, and shear-sensitive hydrogels. We discuss the theoretical analysis of hydrogel properties and the mechanisms used to create these responses, highlighting both the pioneering and most recent work in all of these fields. Finally, we review the many current and proposed applications of these hydrogels in medicine and industry.

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“…Forbes et al recently employed an activators regenerated by electron transfer (ARGET) atom transfer radical polymerization (ATRP) emulsion polymerization technique to synthesize cationic nanogels composed of diethylaminoethyl methacrylate with poly(ethylene glycol) tethers that could be complexed with siRNA and loaded with a small molecule drug. Particle hydrodynamic diameters were 120nm with pH dependent drug release, and have potential for oral delivery to colon cancer or to multi-drug resistant cancer cells by intravenous injection [26]. Hammond and colleagues have utilized layer-by-layer (LbL) nanoparticles for a multitude of applications including drug and siRNA delivery to triple-negative breast cancer.…”

Section: 1 Design Of Intelligent Nanoparticles For Cancer Therapymentioning

confidence: 99%

Intelligent nanoparticles for advanced drug delivery in cancer treatment

Spencer

Puranik

Peppas

2015

Current Opinion in Chemical Engineering

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Treatment of cancer using nanoparticle-based approaches relies on the rational design of carriers with respect to size, charge, and surface properties. Polymer-based nanomaterials, inorganic materials such as gold, iron oxide, and silica as well as carbon based materials such as carbon nanotubes and graphene are being explored extensively for cancer therapy. The challenges associated with the delivery of these nanoparticles depend greatly on the type of cancer and stage of development. This review highlights design considerations to develop nanoparticle-based approaches for overcoming physiological hurdles in cancer treatment, as well as emerging research in engineering advanced delivery systems for the treatment of primary, metastatic, and multidrug resistant cancers. A growing understanding of cancer biology will continue to foster development of intelligent nanoparticle-based therapeutics that take into account diverse physiological contexts of changing disease states to improve treatment outcomes.

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Polycationic nanoparticles synthesized using ARGET ATRP for drug delivery

Cited by 31 publications

References 28 publications

Surface-Modified P(HEMA-co-MAA) Nanogel Carriers for Oral Vaccine Delivery: Design, Characterization, and In Vitro Targeting Evaluation

Surface-Modified P(HEMA-co-MAA) Nanogel Carriers for Oral Vaccine Delivery: Design, Characterization, and In Vitro Targeting Evaluation

Stimulus-responsive hydrogels: Theory, modern advances, and applications

Intelligent nanoparticles for advanced drug delivery in cancer treatment

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