Polycaprolactone fibers with self-assembled peptide micro/nanotubes: a practical route towards enhanced mechanical strength and drug delivery applications

Abstract

The conjugation between micro/nanotubes of l,l-diphenylalanine and polycaprolactone has led to ductile composite fibers suitable for designing polymer membranes potentially usable as degradable skin patches in drug delivery.

Self-assembly of dipeptide Boc-diphenylalanine nanotubes inside electrospun polymeric fibers with strong piezoelectric response

“…40 Electrospun membranes of poly-3-caprolactone (PCL) with Phe-Phe self-assembled nanotubes were investigated for drug delivery. 41 These hybrid composite materials were found to have enhanced mechanical strength and Young's moduli for 40% and 50% lling of PCL with the peptide, resulting in an overall enhancement of the elastic properties of the composite. 41 Here we report the fabrication of electrospun hybrid structures by embedding Boc-Phe-Phe inside a polymer matrix using the high electric elds associated with the electrospinning technique.…”

“…41 These hybrid composite materials were found to have enhanced mechanical strength and Young's moduli for 40% and 50% lling of PCL with the peptide, resulting in an overall enhancement of the elastic properties of the composite. 41 Here we report the fabrication of electrospun hybrid structures by embedding Boc-Phe-Phe inside a polymer matrix using the high electric elds associated with the electrospinning technique. Easily handled two-dimensional polymer arrays containing dipeptide NT assemblies running along the longitudinal electrospun ber axis were obtained.…”

Emerging Considerations for the Future Development of Electrochemical Paper‐Based Analytical Devices

“…Unlike optical profilometry, X‐ray micro‐computed tomography (Micro‐CT) is a versatile technique for studying polymer and paper 3D properties such as fiber orientation, porosity, ink deposition, and adhesiveness and even the presence of strange bodies in the paper structure . However, it is more expensive than other imaging techniques.…”

Preparation, oil adsorption behavior, and mechanism of micro/nanofibrous polycaprolactone membrane prepared through solution blow spinning

“…It can be degraded to carbon dioxide and water in about 6 months in both soil and aquatic environments . Because of its good biocompatibility, PCL fibers are widely used as drug controlled release carriers and surgical sutures . However, there are no reports of its use as an oil‐adsorbing material.…”

“…20 Because of its good biocompatibility, PCL fibers are widely used as drug controlled release carriers and surgical sutures. 22,23 However, there are no reports of its use as an oil-adsorbing material. Meanwhile, owing to the good solubility of PCL in various solvents, 24 it is possible to prepare PCL fibrous membrane through SBS.…”