Polycaprolactone Based Nanoparticles Loaded with Indomethacin for Anti-Inflammatory Therapy: From Preparation to Ex Vivo Study

Badri, Waisudin; Miladi, Karim; Robin, Sophie; Viennet, Céline; Nazari, Qand Agha; Agusti, Géraldine; Fessi, Hatem; Elaı̈ssari, Abdelhamid

doi:10.1007/s11095-017-2166-7

Cited by 65 publications

(32 citation statements)

References 27 publications

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“…Owing to its high permeability for small drug molecules [10], the aliphatic polyester, PCL represents an important candidate for fabricating carriers for drug delivery applications, including: microparticles [11], nanoparticles [12], microspheres [13], coatings [14], and scaffolds [15]. However, due to its intrinsic high hydrophobicity and crystallinity, PCL degrades rather slowly.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions

et al. 2020

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Our study focused on the long-term degradation under simulated conditions of coatings based on different compositions of polycaprolactone-polyethylene glycol blends (PCL-blend-PEG), fabricated for titanium implants by a dip-coating technique. The degradation behavior of polymeric coatings was evaluated by polymer mass loss measurements of the PCL-blend-PEG during immersion in SBF up to 16 weeks and correlated with those yielded from electrochemical experiments. The results are thoroughly supported by extensive compositional and surface analyses (FTIR, GIXRD, SEM, and wettability investigations). We found that the degradation behavior of PCL-blend-PEG coatings is governed by the properties of the main polymer constituents: the PEG solubilizes fast, immediately after the immersion, while the PCL degrades slowly over the whole period of time. Furthermore, the results evidence that the alteration of blend coatings is strongly enhanced by the increase in PEG content. The biological assessment unveiled the beneficial influence of PCL-blend-PEG coatings for the adhesion and spreading of both human-derived mesenchymal stem cells and endothelial cells.

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Section: Introductionmentioning

confidence: 99%

Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions

et al. 2020

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“…As previously described, nonsteroidal antiinflammatory drugs can cause numerous serious side effects 25. Therefore, antiinflammatory agents based on nanomaterials emerge as potent drug systems to treat RA 76…”

Section: Nanotherapeutics Of Ra Based On Nanodrugsmentioning

confidence: 99%

“…[25] Therefore, antiinflammatory agents based on nanomaterials emerge as potent drug systems to treat RA. [76] Curcumin, a major extraction derived from turmeric, has excellent antitumor, antimicrobial, and antioxidant properties. Owing to these predominant properties, Cur has been used as therapeutic agents for various diseases such as chronic inflammatory, diabetes, cutaneous diseases, and so forth.…”

Section: Antiinflammatory Therapymentioning

confidence: 99%

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Wang

Meng

et al. 2020

Adv Healthcare Materials

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Early diagnosis, standardized treatment, and regular monitoring are the clinical treatment principle of rheumatoid arthritis (RA). The overarching principles and recommendations of treat‐to‐target (T2T) in RA advocate remission as the optimum aim, especially for patients with very early disease who are initiating therapy with anti‐RA medications. However, traditional anti‐RA drugs cannot selectively target the inflammatory areas and may cause serious side effects due to its short biological half‐life and poor bioavailability. These limitations have significantly driven the research and application of nanomaterial‐based drugs in theranostics of RA. Nanomedicines have appropriate sizes and easily modified surfaces which can enhance their biological compatibility and prolong circulation time of drug‐loading systems in vivo. Traditional T2T regimens cannot evaluate the efficacy of drugs in real time, while clinical drug nanosizing can realize the integration of diagnosis and treatment of RA. This review bridges clinically proposed T2T concepts and nanomedicine in an integrated system for RA early‐stage diagnosis and treatment. The most advanced progress in various nanodrug delivery systems for theranostics of RA is summarized, establishing a clear path and a new perspective for further optimization of T2T. Finally, the key facing challenges are discussed and prospects are addressed.

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“…In contrast to previous investigations on PCL-based microspheres and lms, we demonstrate here for the rst time that we can design nanocarriers based on PCL with diol functionality that allow for a fast payload release of hydrophilic compounds depending on the number of degradable segments and the morphology of the nanocarriers (which is usually not the case if polycaprolactone is used as a biodegradable polymer). 63,64 As compared to other commonly used biodegradable polymers such as polylactic acid, poly glycolic acid, and poly(lactic-co-glycolic acid), polycaprolactone degrades slowly due to the latter's hydrophobicity and crystallinity. 65 However, based on the obtained results via our elegant interfacial formulation procedure, we have shown that the degradation prole can be tuned.…”

Section: Ph-dependent Release Kineticsmentioning

confidence: 99%

Morphology-dependent pH-responsive release of hydrophilic payloads using biodegradable nanocarriers

et al. 2018

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Polycaprolactone Based Nanoparticles Loaded with Indomethacin for Anti-Inflammatory Therapy: From Preparation to Ex Vivo Study

Abstract: The prepared nanoparticles are submicron in nature, with good colloidal stability and penetrate the stratum corneum layer of the skin. This formulation potentiates IND skin penetration and as a promising strategy would be able to decline the side effects of IND.

Cited by 65 publications

References 27 publications

Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions

Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Morphology-dependent pH-responsive release of hydrophilic payloads using biodegradable nanocarriers

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