Polycaprolactone-based <i>in situ</i> implant containing curcumin-PLGA nanoparticles prepared using the multivariate technique

Kasinathan, Narayanan; Amirthalingam, Muthukumar; Reddy, Neetinkumar D.; Vanthi, Meenashi B; Volety, Subrahmanyam Mallikarjuna; Rao, J. Venkata

doi:10.3109/21691401.2015.1058810

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…However, MBGs are not optimal for scaffolds because of their high brittleness and low fracture toughness and do not meet the mechanical strength requirements of clinical bone repair, especially in mesoporous form [28,33]. Synthetic bioresorbable polymers are known for their high modifiability because these polymers can be easily fabricated into complex structures [6,15,34,35]. However, their performance in cell attachment, proliferation and osteoconductivity is poor because of the lack of specific cell-recognition signals [36].…”

Section: Discussionmentioning

confidence: 99%

Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects

Cheng

Zhang

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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Chronic osteomyelitis and infected bone defects are substantial challenges faced by orthopaedic surgeons. In this study, vancomycin was loaded into mesoporous bioactive glass (MBG) to form a local antibiotic delivery system and then a bone tissue-engineering scaffold combining MBG and poly-(L-lactic-co-glycolic acid) (PLGA) was prepared by freeze-drying fabrication. In vitro degradation and water contact angle analysis suggested that the MBG-incorporated PLGA scaffold exhibited controlled degradability, stabilizing the pH of the surrounding environment and improved the hydrophilicity. Moreover, the presence of MBG provides a well-interconnected pore structure, to which human bone marrow-derived mesenchymal stem cells can attach, spread and proliferate, promoting upregulation of the expression of osteogenic markers. Thus, MBG/PLGA scaffolds exhibit better cytocompatibility and osteoblastic difierentiation properties compared with pure PLGA scaffolds. Vancomycin-loaded scaffolds have been found to yield sustained release that lasts for more than eight weeks in vitro. We tested the antibacterial performance of vancomycin-loaded scaffolds against Staphylococcus aureus, the most common bacteria isolated from infected bone. In vitro experiments demonstrated that loading vancomycin onto the scaffold promoted antibacterial activity and inhibited biofilm formation without deleterious effect on cytocompatibility. In conclusion, the novel inorganic-organic composites are considered potential materials for the treatment of infected bone defects.

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Section: Discussionmentioning

confidence: 99%

Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects

Cheng

Zhang

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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Preclinical studies of the antitumor effect of curcumin‐loaded polymeric nanocapsules: A systematic review and meta‐analysis

Oliveira

Stein

Andrade

et al. 2022

Phytotherapy Research

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Curcumin, a plant-derived compound, has various well-known biological effects (antiinflammatory, antioxidant, antitumor, among others) as well as some important limitations for formulators, such as poor water solubility and low oral bioavailability. Its nanoencapsulation is reported to overcome these drawbacks and to improve its in vivo efficacy. Here, data from preclinical in vivo studies evaluating the antitumor efficacy of curcumin-loaded polymeric nanocapsules are collected, analyzed, and discussed as a systematic review. Meta-analyses are performed to assess the contribution of this nanoencapsulation compared with nonencapsulated curcumin. Eighteen studies (116 animals) meet the inclusion criteria. The evidence that curcumin-loaded polymeric nanocapsules inhibits tumor growth (SMD: À3.03; 95% CI: À3.84, À2.21; p < 0.00001) and decreases tumor weight (SMD: À3.96; 95% CI: À6.22, À1.70; p = 0.0006) in rodents is established, regardless of the solid tumor model. To assess the quality of the studies included in the review a bias risk analysis was performed using the SYRCLE's RoB tool. Therefore, encapsulation in polymeric nanocapsules represents an important tool to improve the antitumor effects of curcumin, and this systematic review paves the way for future clinical studies and the translation of curcumin formulations into novel nanomedicines for human cancer treatment.

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Curcumin encapsulation in functional PLGA nanoparticles: A promising strategy for cancer therapies

Feltrin

Agner

Sayer

et al. 2022

Advances in Colloid and Interface Science

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Polycaprolactone-based in situ implant containing curcumin-PLGA nanoparticles prepared using the multivariate technique

Cited by 4 publications

References 23 publications

Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects

Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects

Preclinical studies of the antitumor effect of curcumin‐loaded polymeric nanocapsules: A systematic review and meta‐analysis

Curcumin encapsulation in functional PLGA nanoparticles: A promising strategy for cancer therapies

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