Polybrominated diphenyl ethers and their hydroxylated and methoxylated derivatives in seafood obtained from Puget Sound, WA

Cade, Sara; Kuo, Lih; Schultz, Irvin R.

doi:10.1016/j.scitotenv.2018.02.301

Cited by 21 publications

(5 citation statements)

References 37 publications

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“…Since some of them have toxic properties similar to those of anthropogenic contaminants, their characterization is needed [ 37 ]. The lack of reports regarding the industrial production of commercially available bromophenols (hydroxylated and methoxylated bromodiphenyl ethers) suggest that they should come from natural sources and from biotransformation of natural and anthropogenic compounds [ 38 ]. Red algae are the major source of natural marine bromophenols [ 39 ], but other organisms such as fish, shrimps and crabs ingest them through the food chain.…”

Section: Marine Phenolics: Sources and Phenolic Compositionmentioning

confidence: 99%

“…Red algae are the major source of natural marine bromophenols [ 39 ], but other organisms such as fish, shrimps and crabs ingest them through the food chain. Cade et al [ 38 ] found polybrominated diphenyl ethers (PBDEs) at higher concentration in finfish than in shellfish. Among shellfish, bivalves (clams and mussels) tended to have higher levels of hydroxylated and methoxylated PBDEs than other types of seafood.…”

Section: Marine Phenolics: Sources and Phenolic Compositionmentioning

confidence: 99%

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Bioactive Properties of Marine Phenolics

2020

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Phenolic compounds from marine organisms are far less studied than those from terrestrial sources since their structural diversity and variability require powerful analytical tools. However, both their biological relevance and potential properties make them an attractive group deserving increasing scientific interest. The use of efficient extraction and, in some cases, purification techniques can provide novel bioactives useful for food, nutraceutical, cosmeceutical and pharmaceutical applications. The bioactivity of marine phenolics is the consequence of their enzyme inhibitory effect and antimicrobial, antiviral, anticancer, antidiabetic, antioxidant, or anti-inflammatory activities. This review presents a survey of the major types of phenolic compounds found in marine sources, as well as their reputed effect in relation to the occurrence of dietary and lifestyle-related diseases, notably type 2 diabetes mellitus, obesity, metabolic syndrome, cancer and Alzheimer’s disease. In addition, the influence of marine phenolics on gut microbiota and other pathologies is also addressed.

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Section: Marine Phenolics: Sources and Phenolic Compositionmentioning

confidence: 99%

Section: Marine Phenolics: Sources and Phenolic Compositionmentioning

confidence: 99%

Bioactive Properties of Marine Phenolics

2020

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“…Table S2 (supplementary data) summarizes published studies from 2004 to 2020 regarding shrimp contamination with BFRs [ 47 , 49 , 51 , 55 , 59 , 62 , 64 , 68 , 69 , 70 , 74 , 75 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 ]. As shown in Table S2, 30 different PBDEs were analysed.…”

Section: Occurrence Of Pollutants In Shrimpsmentioning

confidence: 99%

“…Being the number of individuals collected between 2 [ 96 ] and 180 [ 70 ], and the number of specimens per pool analysed between 7 [ 84 – 86 ] and 50 [ 97 ]. Concerning the sample collection, some authors reported that they purchased the samples at local markets [ 47 , 59 , 75 , 78 , 79 , 82 , 89 , 91 , 93 , 95 , 96 ] or directly from local fishermen [ 68 , 70 , 94 ]. The sample catchment methods applied were trawl fishing [ 49 , 51 , 62 , 64 , 77 , 97 , 101 ] and electric pulse fishing [ 68 , 84 , 85 , 86 ].…”

Section: Occurrence Of Pollutants In Shrimpsmentioning

confidence: 99%

Organochlorine pesticides, brominated flame retardants, synthetic musks and polycyclic aromatic hydrocarbons in shrimps. An overview of occurrence and its implication on human exposure

Maia

Sousa

Correia-Sá

et al. 2020

Heliyon

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Shrimps are widely distributed in coastal areas, estuaries and rivers. Although this shellfish is a good source of nutrients, it can also accumulate environmental contaminants, such as organochlorine pesticides (OCPs), brominated flame retardants (BFRs), synthetic musks (SMs) and polycyclic aromatic hydrocarbons (PAHs). Due to their bioaccumulative properties, these pollutants are endocrine disruptors. In this review, an overview of the world's shrimp market, pollutants legislation and values found in shrimp samples will be discussed. Shrimps analysed from all continents showed the presence of contaminants, Asia being the continent with the highest values reported. The concentration values reached a maximum of 26100 ng/g wet weight (ww) for OCPs, of 226.45 ng/g ww for BFRs, of 12.1 ng/g ww for SMs and of 50650 ng/g ww for PAHs. Exposure data and risk, taken from different studies, are very variable and indicate that shrimp's consumption may represent a risk especially in certain geographic areas.

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“…Although they are persistent, PBDEs can be biotransformed to hyroxylated PBDEs (HO-PBDEs) through various metabolic pathways. − Although the parent PBDEs rather than OH-PBDEs were used in industry, the appalling fact is that a higher concentration of OH-PBDEs over their precursors was found in animal tissues . Moreover, the toxicological effects of the OH-PBDEs are more potent than those of parent PBDEs, especially in endocrine disruption and development neurotoxicity .…”

Section: Introductionmentioning

confidence: 99%

Polybrominated Diphenyl Ethers Quinone Induces NCOA4-Mediated Ferritinophagy through Selectively Autophagic Degradation of Ferritin

Dong

et al. 2019

Chem. Res. Toxicol.

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Polybrominated diphenyl ethers (PBDEs) have been detected ubiquitously in biological and environmental samples. Growing epidemiological data suggested the obvious correlation of PBDEs exposure with adverse health outcomes toward human beings, but exact molecular mechanism(s) are limited. Especially, the toxicological information regarding PBDEs metabolites is missing. Thereafter, this study intends to explore unidentified cell death modalities caused by PBDEs reactive quinone-type metabolite, PBDEQ. We found that PBDEQ induces autophagy in an ROS-dependent manner. Interestingly, the results indicated that PBDEQ degraded ferritin and activated a selective autophagy (termed as ferritinophagy) by using NCOA4 as its cargo receptor. These processes may further promote the release of iron and ROS. These results suggested the incidence of ferritinophagy induced by PBDEQ, which may contribute to PBDE exposure-caused diseases and dysfunctions.

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Polybrominated diphenyl ethers and their hydroxylated and methoxylated derivatives in seafood obtained from Puget Sound, WA

Cited by 21 publications

References 37 publications

Bioactive Properties of Marine Phenolics

Bioactive Properties of Marine Phenolics

Organochlorine pesticides, brominated flame retardants, synthetic musks and polycyclic aromatic hydrocarbons in shrimps. An overview of occurrence and its implication on human exposure

Polybrominated Diphenyl Ethers Quinone Induces NCOA4-Mediated Ferritinophagy through Selectively Autophagic Degradation of Ferritin

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