Polybrominated diphenyl ethers and polychlorinated biphenyls in cord blood from women in Poland

Hernik, Agnieszka; Góralczyk, Katarzyna; Struciński, Paweł; Czaja, Katarzyna; Korcz, Wojciech; Minorczyk, Maria; Ludwicki, Jan K

doi:10.1016/j.chemosphere.2013.06.045

Cited by 15 publications

(6 citation statements)

References 55 publications

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“…, blood pressure) (Liu et al 2015a; Petry et al 2007, 2014). Previous findings showed significant positive correlations between maternal blood concentrations of organohalogens and cord blood after the first trimester (Zhao et al 2013; Vizcaino et al 2014) of pregnancy and between maternal levels and umbilical cord serum at 6 months of pregnancy (Choi et al 2014) and at delivery (Hernik et al 2013) providing evidence of the placental transfer of organohalogens between mother and fetus. High maternal-fetal transfer mean ratios were shown for BDE-47 and BDE-99 in a placenta perfused model but a small overall amount was found in fetus (Frederiksen et al 2010).…”

Section: Discussionmentioning

confidence: 92%

Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants

Traglia

Croen

Lyall

et al. 2017

G3 Genes|Genomes|Genetics

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Maternal exposure to environmental pollutants could affect fetal brain development and increase autism spectrum disorder (ASD) risk in conjunction with differential genetic susceptibility. Organohalogen congeners measured in maternal midpregnancy blood samples have recently shown significant, but negative associations with offspring ASD outcome. We report the first large-scale maternal and fetal genetic study of the midpregnancy serum levels of a set of 21 organohalogens in a subset of 790 genotyped women and 764 children collected in California by the Early Markers for Autism (EMA) Project. Levels of PCB (polychlorinated biphenyl) and PBDE (polybrominated diphenyl ether) congeners showed high maternal and fetal estimated SNP-based heritability (h2g) accounting for 39–99% of the total variance. Genome-wide association analyses identified significant maternal loci for p,p′-DDE (P = 7.8 × 10−11) in the CYP2B6 gene and for BDE-28 (P = 3.2 × 10−8) near the SH3GL2 gene, both involved in xenobiotic and lipid metabolism. Fetal genetic loci contributed to the levels of BDE-100 (P = 4.6 × 10−8) and PCB187 (P = 2.8 × 10−8), near the potential metabolic genes LOXHD1 and PTPRD, previously implicated in neurodevelopment. Negative associations were observed for BDE-100, BDE153, and the sum of PBDEs with ASD, partly explained by genome-wide additive genetic effects that predicted PBDE levels. Our results support genetic control of midgestational biomarkers for environmental exposures by nonoverlapping maternal and fetal genetic determinants, suggesting that future studies of environmental risk factors should take genetic variation into consideration. The independent influence of fetal genetics supports previous hypotheses that fetal genotypes expressed in placenta can influence maternal physiology and the transplacental transfer of organohalogens.

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Section: Discussionmentioning

confidence: 92%

Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants

Traglia

Croen

Lyall

et al. 2017

G3 Genes|Genomes|Genetics

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“…PBDEs are addictive flame retardants, which means that they are linked to the matrix of plastics only by interaction of physical nature. This fact causes a justifiable concern over their uncontrolled infiltration to the environment, which has often been confirmed by worldwide research studies [].…”

Section: Introductionmentioning

confidence: 99%

Methods for determination of polybrominated diphenyl ethers in environmental samples – review

Fulara

Czaplicka

2012

J of Separation Science

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Polybrominated diphenyl ethers (PBDEs) are a group of persistent organic pollutants. They are used as flame retardants in plastics, paints, varnishes and textile materials. PBDEs pose great risk to the environment because of their high persistence and ability to get into the environment easily due to the lack of chemical bonds with the matrix of materials, to which they are added. Global research studies confirmed the occurrence of those compounds in the majority of elements of water and land environment. Analysis of PBDEs in environmental samples is one of the specific analytical methods of criteria that comprise low detection limits and high selectivity. The analysis of PBDEs in environmental samples is one of the specific analytical methods, in which the main criteria are low detection limits and high selectivity. In this article, a literature review of methods for environmental sample preparation and analysis of the PBDE content was presented. The article discusses the potential of modern extraction techniques such as: solid-phase microextraction, single-drop microextraction, dispersive liquid-liquid microextraction, microwave-assisted extraction, cloud point extraction, hollow fibre-liquid phase microextraction and others for the separation of PBDEs from environmental samples with a complex matrix. Among the methods for qualitative and quantitative determination of PBDEs, a particular focus was put on gas chromatography/mass spectrometry with various injection techniques and different types of sample ionisation.

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“…details of both modified methods have been previously described by Hernik et al (2011Hernik et al ( , 2013.…”

Section: Methodsmentioning

confidence: 99%

“…After cooling, 5 ml of the extract was taken for gravimetric measurement of lipids. The extracts were preliminarily cleaned-up with concentrated sulphuric Analyt ical met ho d fo r co rd blo o d (Hernik et al, 2013) A modified version of the extraction method described by Päpke et al (2004), was applied. The cord blood sample was diluted in water and after addition of ethanol it was extracted twice with n-hexane, followed by two consecutive extractions with a mixture of n-hexane and isopropanol.…”

Section: Methodsmentioning

confidence: 99%

“…PBDEs have structural and functional similarities to PCBs. The presence of these organohalogens have been found in various environmental samples, including adipose tissue and maternal milk (Covaci et al, 2002;Gómara et al, 2012;Herbstman et al, 2010;Hernik et al, 2011Hernik et al, , 2013Jaraczewska et al, 2006;Liu et al, 2012;Shen et al, 2008). There is evidence these substances act as PCBs successors as environmental contaminants and may cause a delayed effect in humans (Chen et al, 2015;Costa and Giordano, 2007;Herbstman et al, 2010;Viberg, 2004) .…”

Section: Introductionmentioning

confidence: 99%

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Relationship between paired cord blood and milk POPs levels as a tool for assessing perinatal exposure, a pilot study

Hernik

Struciński

Buckley

et al. 2016

Human and Ecological Risk Assessment: An International Journal

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The long term health threats posed to humans exposed to pollutants acting as endocrine disruptors (EDs) is yet to be quantified. There is insufficient knowledge about the sources and magnitude of exposure to selected polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) during the most sensitive period of fetal development, suggesting the need for a study. Organochlorine pesticides, classified as being persistent organic pollutants (POPs) and potential EDs, were also included in this analysis. Xenobiotics were measured in paired fetal cord blood and maternal breast milk samples. There were no significant differences in the concentrations of PCB-101, PBDE-47 and PBDE-99 between maternal milk and cord blood

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Polybrominated diphenyl ethers and polychlorinated biphenyls in cord blood from women in Poland

Cited by 15 publications

References 55 publications

Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants

Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants

Methods for determination of polybrominated diphenyl ethers in environmental samples – review

Relationship between paired cord blood and milk POPs levels as a tool for assessing perinatal exposure, a pilot study

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