Relationship between paired cord blood and milk POPs levels as a tool for assessing perinatal exposure, a pilot study

Abstract

The long term health threats posed to humans exposed to pollutants acting as endocrine disruptors (EDs) is yet to be quantified. There is insufficient knowledge about the sources and magnitude of exposure to selected polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) during the most sensitive period of fetal development, suggesting the need for a study. Organochlorine pesticides, classified as being persistent organic pollutants (POPs) and potential EDs, were also included in this analysis. Xenobiotics were measured in paired fetal cord blood and maternal breast milk samples. There were no significant differences in the concentrations of PCB-101, PBDE-47 and PBDE-99 between maternal milk and cord blood

Prenatal exposure to persistent organic pollutants in Northern Tanzania and their distribution between breast milk, maternal blood, placenta and cord blood

“…This is also suggested for PBDEs by others (Kim et al 2012). Furthermore, Hernik et al (2016) found insignificant differences in concentrations of PCB-101, BDE-47 and BDE-99 between breast milk and cord blood concentrations. However, contradictory to the p,p´-DDE distribution in the present study, Hernik et al (2016) found significantly higher concentrations in breast milk than cord blood for p,p'-DDE and other POPs, i.e.…”

Scopes of Bioanalytical Chromatography–Mass Spectrometry

“…Russkikh et al [10] reported the results of the individual determination of compounds included in the HELCOM list of the Helsinki Commission for the Protection of the Marine Environment by liquid CMS with tandem mass-spectrometric detection (HPLC-MS/MS) and proposed a procedure for the simultaneous determination of a group of perfluoroorganic acids, estradiol derivatives, hexabromocyclododecane, and triclosan. Breast milk, blood, and umbilical cord blood are commonly used to determine polychlorinated biphenyls, dioxins, organochlorine pesticides, bromine-containing flame retardants, perfluorinated compounds, and organotin compounds [11,12]. Urine samples are analyzed for bisphenol A, organophosphates, hydroxylated metabolites of polyaromatic hydrocarbons, and phthalates [13,14].…”