Polyautoimmunity in a Greek cohort of multiple sclerosis

Deretzi, Georgia; Kountouras, Jannis; Polyzos, Stergios A.; Koutlas, Evangelos; Pelidou, Sygkliti-Henrietta; Xeromerisiou, G.; Zavos, Christos; Tsiptsios, Iakovos

doi:10.1111/ane.12308

Cited by 13 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After removing duplicates, our systematic search identified 285 studies. Ultimately, a total of six case-control studies with 12,930 study subjects that investigated the association of MS with vitiligo met our inclusion criteria [18][19][20][21][22][23] . We found no relevant cross-sectional or cohort studies.…”

Section: Resultsmentioning

confidence: 99%

“…In the Seyfert 1990 study, there were no cases of MS with vitiligo 19 ; therefore, we could not calculate the OR. Only one study 18 reported a positive association of MS with prevalent vitiligo. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Fig. 3 , our meta-analysis was based on five case–control studies, involving a total of 12,829 MS patients and 31,231 controls 18 , 20 – 23 . No significant association of MS with prevalent vitiligo was found (pooled OR 1.33; 95% confidence interval [CI] 0.80‒2.22; I 2 = 44%).…”

Section: Resultsmentioning

confidence: 99%

“…Different types of autoimmune diseases may have shared pathways and may therefore be associated with each other 26 . By using a Greek population, Deretzi and colleagues found a significantly higher prevalence of vitiligo in MS patients than in controls 18 . However, the present meta-analysis did not support an association between MS and vitiligo.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Association of multiple sclerosis with vitiligo: a systematic review and meta-analysis

Shen

Chang

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Polyautoimmunity implicates that some autoimmune diseases share common etiopathogenesis. Some studies have reported an association between multiple sclerosis (MS) and vitiligo; meanwhile, other studies have failed to confirm this association. We performed a systemic review and meta-analysis to examine the association of MS with vitiligo. We searched the MEDLINE and Embase databases on March 8, 2020 for relevant case–control, cross-sectional, and cohort studies. The Newcastle–Ottawa Scale was used to evaluate the risk of bias of the included studies. Where applicable, we performed a meta-analysis to calculate the pooled odds ratio (OR) for case–control/cross-sectional studies and risk ratio for cohort studies with 95% confidence interval (CI). Our search identified 285 citations after removing duplicates. Six case–control studies with 12,930 study subjects met our inclusion criteria. Our meta-analysis found no significant association of MS with prevalent vitiligo (pooled OR 1.33; 95% CI 0.80‒2.22). Analysis of the pooled data failed to display any increase of prevalent vitiligo in MS patients compared with controls. Ethnic and genetic factors may play an important role for sporadically observed associations between MS and vitiligo. Future studies of this association should therefore consider stratification by ethnic or genetic factors.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Association of multiple sclerosis with vitiligo: a systematic review and meta-analysis

Shen

Chang

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Последние встречаются при РС с такой же частотой, как и в об-щей популяции, а иногда и реже [5,12]. Для пони-мания данного феномена большое значение приоб-ретают генетические исследования, в частности из-учение однонуклеотидных полиморфизмов (ОНП).…”

Section: распространенность и структура коморбидных аиз у больных рс unclassified

Comorbid autoimmune pathology in patients treated with disease modifying drugs

Гончарова

Sizyakinа

Belovolova

et al. 2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

View full text Add to dashboard Cite

Multiple sclerosis and inflammatory bowel disease: A systematic review and meta‐analysis

Wang

Wan

Wang

et al. 2022

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Background Multiple sclerosis (MS) and inflammatory bowel disease (IBD) are two autoimmune diseases that seriously affect patients' quality of life. Previous studies have established an association between MS and IBD, including Crohn's disease (CD) and ulcerative colitis (UC), but the results were inconsistent. The aim of this study was to quantify the prevalences of and the association between MS and IBD. Methods The PubMed, Web of Science, and Embase databases were searched through November 2020 for studies reporting data on MS among patients with IBD and vice versa. The main outcomes were the proportion of MS in patients with IBD and vice versa, as well as the association (risk ratio [RR]) of IBD in MS and that of MS in IBD. Results Based on the analysis of 17 studies, the prevalence of MS in patients with IBD was 0.2% (95% CI 0.1–0.4%), while the prevalence of IBD in patients with MS was 0.6% (95% CI 0.4–0.9%). Patients with MS had a higher prevalence of IBD than controls (RR = 1.53, 95% CI 1.38–1.70, p < 0.00001). There was a similarly high risk of developing CD (RR 1.41, 95% CI 1.14–1.74, p = 0.001) or UC (RR 1.42, 95% CI 1.17–1.71, p = 0.0003) in patients with MS (p for subgroup differences: 0.97). Patients with IBD had a higher prevalence of MS than controls (RR = 1.91, 95% CI 1.06–3.45, p = 0.03). Conclusions Clinicians should be aware of the increased risk of IBD or MS comorbidity during the diagnostic process. Systematic diagnosis and management at an earlier stage are suggested.

show abstract

Polyautoimmunity in a Greek cohort of multiple sclerosis

Cited by 13 publications

References 33 publications

Association of multiple sclerosis with vitiligo: a systematic review and meta-analysis

Association of multiple sclerosis with vitiligo: a systematic review and meta-analysis

Comorbid autoimmune pathology in patients treated with disease modifying drugs

Multiple sclerosis and inflammatory bowel disease: A systematic review and meta‐analysis

Contact Info

Product

Resources

About