Association of multiple sclerosis with vitiligo: a systematic review and meta-analysis

Abstract

Polyautoimmunity implicates that some autoimmune diseases share common etiopathogenesis. Some studies have reported an association between multiple sclerosis (MS) and vitiligo; meanwhile, other studies have failed to confirm this association. We performed a systemic review and meta-analysis to examine the association of MS with vitiligo. We searched the MEDLINE and Embase databases on March 8, 2020 for relevant case–control, cross-sectional, and cohort studies. The Newcastle–Ottawa Scale was used to evaluate the risk of bias of the included studies. Where applicable, we performed a meta-analysis to calculate the pooled odds ratio (OR) for case–control/cross-sectional studies and risk ratio for cohort studies with 95% confidence interval (CI). Our search identified 285 citations after removing duplicates. Six case–control studies with 12,930 study subjects met our inclusion criteria. Our meta-analysis found no significant association of MS with prevalent vitiligo (pooled OR 1.33; 95% CI 0.80‒2.22). Analysis of the pooled data failed to display any increase of prevalent vitiligo in MS patients compared with controls. Ethnic and genetic factors may play an important role for sporadically observed associations between MS and vitiligo. Future studies of this association should therefore consider stratification by ethnic or genetic factors.

relationship between risk factor and clinical type of vitiligo in dermatology and venerology outpatient clinic Dr. Soetomo General Academic Hospital Surabaya

“…It was reported that HSP70i from melanocytes in accelerating autoimmune vitiligo. Stressed cells secrete HSP70i and in the extracellular environment, HSP70i could activate dendritic cells (DCs) and aid in antigen cross-presentation, resulting in a cytotoxic T cell response to melanocytic antigens (Han Shen et al,2020). The exact role of stress in the pathogenesis of vitiligo and the relationship between stress and the development of various types of vitiligo lesions should be clarified by prospective studies with a clinical and immunoserological focus.…”

Association of vitiligo with high‐frequency sensorineural hearing loss: a systematic review and meta‐analysis

“…Vitiligo is an autoimmune depigmenting dermatosis with multifactorial aetiology and considerable impact on the quality of life. 1,2 The prevalence of vitiligo varies among different populations and ranges from 0.2% to 1.8%. 3 Vitiligo presents with sharply marginated depigmented patches due to a progressive loss of functional melanocytes.…”

“…4 Multiple aetiological hypotheses have been proposed, including genetic factors, oxidative stress, protein adhesion defect, and autoimmune reaction. 1 In particular, the autoimmune mechanism is considered the most well established one. 5 Many studies have indicated that in vitiligo patients, a systemic melanocyte destruction happens in the epidermis, hair follicles, mucous membrane, retinal pigment epithelium, leptomeninges, and inner ear.…”

“…Vitiligo is an autoimmune depigmenting dermatosis with multifactorial aetiology and considerable impact on the quality of life 1,2 . The prevalence of vitiligo varies among different populations and ranges from 0.2% to 1.8% 3 .…”

“…Vitiligo presents with sharply marginated depigmented patches due to a progressive loss of functional melanocytes 4 . Multiple aetiological hypotheses have been proposed, including genetic factors, oxidative stress, protein adhesion defect, and autoimmune reaction 1 . In particular, the autoimmune mechanism is considered the most well established one 5 .…”