Polyarthritis and Membranoproliferative Glomerulonephritis as Paraneoplastic Manifestation of Hodgkin's Lymphoma: A Case Report and Literature Review

Erlij, Daniel; Calderón, Beatriz; Rivera, Ángela; Mella, Cristián; Valladares, Ximena; Roessler, Emilio; Rivera, Maria; Méndez, Gonzalo

doi:10.1016/j.reumae.2015.10.009

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…Concomitantly, Handy et al [34] described the only case of a RA-like polyarthritis developing in a patient with a T cell ALL. Furthermore, Erlij et al [35], reported one of the few cases of Hodgkin lymphoma held responsible for articular paraneoplastic manifestations.…”

Section: Hematological Malignanciesmentioning

confidence: 99%

Paraneoplastic arthritides: an up-to-date case-based systematic review

Khayyat¹,

Conticini²,

Falsetti³

et al. 2022

Reumatologia

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Among the rheumatic diseases whose symptoms are more often associated with the possibility of cancer and other malignancies are systemic sclerosis, dermatomyositis and rheumatic polymyalgia. However, a differential diagnosis should be performed in each case of non-typical rheumatic disease and/or other neoplastic disease risk factors. The article’s aim was based on a literature review of this subject and presentation own a case description and discussion about arthritis as a paraneoplastic syndrome. The conclusions of our analysis were as follows: more often paraneoplastic arthritis occurs in men, in ages higher than 50 years old, in patients who poorly respond to treatment of arthritis with polyarticular symmetrical involvement of the limbs, seronegative type of inflammatory joint disease. In this group of patients, complete remission after treatment of the primary tumor and recurrence of the symptoms in the presence of metastasis was observed.

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Section: Hematological Malignanciesmentioning

confidence: 99%

Paraneoplastic arthritides: an up-to-date case-based systematic review

Khayyat¹,

Conticini²,

Falsetti³

et al. 2022

Reumatologia

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“…A case report by Erlij et al describes a patient presenting with symmetric, seronegative polyarthritis and acute renal failure about three months prior to a diagnosis of HL. Although his arthritis responded to steroids initially, he had a recurrence of renal failure which resolved only with ABVD chemotherapy [84]. Although polyarthritis did not recur like kidney dysfunction, its timing and lack of recurrence are certainly suggestive of paraneoplastic pathology related to HL.…”

Section: Miscellaneous Paraneoplastic Arthritismentioning

confidence: 95%

“…However, it resolved with ABVD chemotherapy [85]. Although paraneoplastic arthritis has been associated with antinuclear antibodies and rheumatoid factor in other malignancies [84], both these cases were seronegative.…”

Section: Miscellaneous Paraneoplastic Arthritismentioning

confidence: 99%

Paraneoplastic Syndromes in Hodgkin’s Lymphoma

Jadoon,

Patil,

Loke

et al. 2024

Lymphatics

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Hodgkin’s lymphoma (HL) is a monoclonal lymphoid neoplasm that is mainly characterized by multinucleated Reed–Sternberg cells on a background of non-neoplastic inflammatory cells. The incidence rate of Hodgkin’s lymphoma is 2.5 new cases per 100,000 people per year (1). Paraneoplastic syndromes are conditions that are related to malignancy; however, they are not a result of tumor invasion or compression of malignant tissues. These paraneoplastic syndromes can occur virtually at any point in the disease course, and paraneoplastic syndromes in HL and their various forms are not well studied. In this review article, we will be discussing paraneoplastic syndromes in general and then delve into specific syndromes seen in HL, followed by a brief discourse regarding their early recognition and timely management.

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“…1 Since then, there have been a multitude of reports on PNS, which is observed in approximately 8-10% of all malignant tumors. [1][2][3] PNS can affect any organ or tissue. It is generally due to ectopic hormone or cytokine production, or may be related to autoimmune factors.…”

mentioning

confidence: 99%

“…[5][6][7] In addition to the above, hepatic, dermatologic, and rheumatologic manifestations have also been described in adults. 3,6,[8][9][10][11] PNS in children with HL is relatively rare, with few published case reports and case series in this population. This article will review the state of knowledge of PNS in pediatric HL.…”

mentioning

confidence: 99%

Paraneoplastic Syndromes in Children with Hodgkin Lymphoma

Betcherman¹,

Punnett²

2017

Oncology &Amp; Hematology Review (US)

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Paraneoplastic syndromes (PNS) refer to a phenomenon whereby certain malignancies manifest as symptoms not directly related to the tumor itself. PNS has been described in association with Hodgkin lymphoma (HL) in adults and children and may affect a number of organ systems. The pathophysiology is variable and in many cases is not well understood. Specific paraneoplastic antibodies have been isolated in some syndromes, though are not required for the diagnosis. The two best described for HL are the anti-Tr and anti-mGluR5 antibodies identified in some cases of limbic encephalitis and cerebellar degeneration respectively. A high index of suspicion for underlying malignancy is necessary when recognizing these clinical syndromes to avoid a diagnostic delay. Successful treatment of the HL often reverses the manifestations of PNS although organ function at diagnosis may limit therapeutic options. Some patients suffer devastating complications of their PNS.

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Polyarthritis and Membranoproliferative Glomerulonephritis as Paraneoplastic Manifestation of Hodgkin's Lymphoma: A Case Report and Literature Review

Cited by 4 publications

References 8 publications

Paraneoplastic arthritides: an up-to-date case-based systematic review

Paraneoplastic arthritides: an up-to-date case-based systematic review

Paraneoplastic Syndromes in Hodgkin’s Lymphoma

Paraneoplastic Syndromes in Children with Hodgkin Lymphoma

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