Paraneoplastic arthritides: an up-to-date case-based systematic review

Abstract

Among the rheumatic diseases whose symptoms are more often associated with the possibility of cancer and other malignancies are systemic sclerosis, dermatomyositis and rheumatic polymyalgia. However, a differential diagnosis should be performed in each case of non-typical rheumatic disease and/or other neoplastic disease risk factors. The article’s aim was based on a literature review of this subject and presentation own a case description and discussion about arthritis as a paraneoplastic syndrome. The conclusions of our analysis were as follows: more often paraneoplastic arthritis occurs in men, in ages higher than 50 years old, in patients who poorly respond to treatment of arthritis with polyarticular symmetrical involvement of the limbs, seronegative type of inflammatory joint disease. In this group of patients, complete remission after treatment of the primary tumor and recurrence of the symptoms in the presence of metastasis was observed.

First case report of rheumatoid-like paraneoplastic polyarthritis in a patient with Fallopian tube cancer

“…Many features of this case are in line with prior PA literature, namely occurrence as symmetrical polyarthritis in a patient >50 years of age showing poor response to standard therapy with NSAIDs, glucocorticoids and DMARDs, yet complete vanishing of joint complaints after cancer treatment [ 2–4 ]. However, PA patients are usually male and seronegative for RF and CCP, which are detectable in only 23% and 11%, respectively [ 2 , 5 ].…”

“…Notably, PA has most often been found in lung adenocarcinoma and haematological malignancies [ 2 ], and the literature yields only two prior reports of adnexal tumour association: one ovarian teratoma in a 34-year-old woman [ 6 ] and one ovarian cystadenocarcinoma in a 64-year-old woman, who, however, had an additional malignant sarcomatoid lung tumour [ 7 ].…”

Case report: Paraneoplastic arthritis secondary to ovarian teratoma

“…1,2 A recent systematic review found that the mean age of onset for paraneoplastic arthritis was 53 and was more common in males with the most common pattern of presentation being symmetrical polyarthritis. 2 Our case reflects the majority of paraneoplastic arthritis cases, which are seronegative and demonstrate poor response to NSAIDs, glucocorticoids, or conventional DMARDs. 2 Pulmonary and hematological malignancies are most commonly associated with paraneoplastic arthritis.…”

“…2 Our case reflects the majority of paraneoplastic arthritis cases, which are seronegative and demonstrate poor response to NSAIDs, glucocorticoids, or conventional DMARDs. 2 Pulmonary and hematological malignancies are most commonly associated with paraneoplastic arthritis. 2,3 Ovarian teratoma is the most common benign tumor in premenopausal women and is often asymptomatic.…”

“…2 Pulmonary and hematological malignancies are most commonly associated with paraneoplastic arthritis. 2,3 Ovarian teratoma is the most common benign tumor in premenopausal women and is often asymptomatic. These tumors have been associated with several paraneoplastic syndromes including limbic encephalitis, autoimmune hemolytic anemia, dermatomyositis, Hashimoto thyroiditis, and vasculitis.…”