Polyarteritis in mice due to spontaneous hypertension

Mullink, J. W. M. A.; Haneveld, G.T.

doi:10.1016/0021-9975(79)90013-6

Cited by 12 publications

(6 citation statements)

References 4 publications

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“…36,43,64 However, hypertension may also have a primary role in the development of murine polyarteritis. 37 Interestingly, in a study of 11 commonly used inbred mouse strains, male 129S1/SvImJ mice exhibited the highest systolic blood pressure. 8 Given the assumption that the same male-predominant high blood pressure phenotype is equally represented among different 129 substrains, hypertension in aging 129S6/SvEvTac males might be involved in the pathogenesis of polyarteritis.…”

Section: Discussionmentioning

confidence: 99%

The Pathology of Aging 129S6/SvEvTac Mice

et al. 2015

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The 129 mouse strain is commonly used for the generation of genetically engineered mice. Genetic drift or accidental contamination during outcrossing has resulted in several 129 substrains. Comprehensive data on spontaneous age-related pathology exist for the 129S4/SvJae substrain, whereas only limited information is available for other 129 substrains. This longitudinal aging study describes the life span and spontaneous lesions of 44 male and 18 female mice of the 129S6/SvEvTac substrain. Median survival time was 778 and 770 days for males and females, respectively. Tumors of lung and Harderian gland were the most common neoplasms in both sexes. Hepatocellular tumors occurred mainly in males. Hematopoietic tumors were observed at low frequency. Suppurative and ulcerative blepharoconjunctivitis was the most common nonneoplastic condition in both sexes. Corynebacteria (primarily Corynebacterium urealyticum and C. pseudodiphtheriticum) were isolated from animals with blepharoconjunctivitis and in some cases from unaffected mice, although a clear causal association between corynebacterial infections and blepharoconjunctivitis could not be inferred. Polyarteritis occurred only in males and was identified as the most common nonneoplastic contributory cause of death. Eosinophilic crystalline pneumonia occurred in both sexes and was a relevant cause of death or comorbidity. Epithelial hyalinosis at extrapulmonary sites was noted at higher frequency in females. This study contributes important data on the spontaneous age-related pathology of the 129S6/SvEvTac mouse substrain and is a valuable reference for evaluation of the phenotype in genetically engineered mice obtained with this 129 substrain.Keywords 129 mouse, aging, blepharoconjunctivitis, Harderian gland, hyalinosis, phenotyping Each inbred laboratory mouse strain exhibits a unique spectrum of naturally occurring lesions that develop progressively with age. Crosses of different strains usually result in variations of the original strain-specific phenotype, which include vanishing, attenuation, or exacerbation of expected lesions or even development of completely new conditions. 20,72 In this context, an accurate definition of strain-specific pathology in those inbred mice that are most frequently used in biomedical research (especially for the generation of genetically engineered mice) is crucial to understand whether a phenotype results from the experimental intervention or rather reflects a naturally occurring entity. 3,54,62 In addition, longitudinal survival studies determining the aging phenotype of inbred strains are particularly important, as they provide a useful reference that enables the selection of the most appropriate genetic background for specific experiments and facilitates the interpretation of clinicopathologic changes that develop in long-term studies. 3,45,72 Thorough and comprehensive pathologic analysis of inbred strains is important not only for interpreting lesions in the setting of hypothesis-driven research but also for large-sc...

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Section: Discussionmentioning

confidence: 99%

The Pathology of Aging 129S6/SvEvTac Mice

et al. 2015

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“…The occurrence and severity of this change varies with age, strain and sex, but the etiology is generally considered to be unknown , Faccini et al 1990, Frith & Ward 1988, Frith et al 2007, Percy & Barthold 2007. There are reports of correlations between elevated blood pressure in mice and an increased incidence of polyarteritis (Mullink & Haneveld 1979). Histologically, the affected arteries typically show hyaline degeneration of the walls of the vessel with associated inflammatory cell infiltration affecting the intima, media and adventitia.…”

Section: Hemolymphoreticular Systemmentioning

confidence: 99%

Mouse

Taylor¹

2012

Background Lesions in Laboratory Animals

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“…4,16 The disease in mice has been reported in several different strains and has often included involvement of the aorta. 11,14,15 A polyarteritis syndrome has been recognized in juvenile Beagles. 13 This syndrome is characterized by fever and consistent involvement of cardiac, cranial mediastinal, and cervical meningeal vessels.…”

mentioning

confidence: 99%

“…PAN is most common in adults, and the pathogenesis is uncertain. In animals, reports of PAN-like diseases have included rats, 4,16 mice, 11,14,15 dogs, 13 cats, 2 and pigs. 9 Among nonhuman primates, the disease has been described only in the cynomolgus macaque (Macaca fascicularis).…”

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confidence: 99%

Polyarteritis Nodosa in a Cynomolgus Macaque (Macaca fascicularis)

Porter

Frost²,

Hubbard³

2003

Vet Pathol

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Abstract. Polyarteritis nodosa (PAN) is an idiopathic necrotizing vasculitis affecting small-to mediumsized arteries. The disease is well recognized in humans, and PAN-like syndromes have been described in a number of other species. This report describes a case of PAN in a 6-year-old male cynomolgus macaque. The animal had necrotizing arteritis affecting vessels in the kidney, small intestine, colon, heart, spleen, mesentery, urinary bladder, and pancreas. The lesions were segmental in distribution and of varying severity and stage of development. A transmural mixed inflammatory cell infiltrate was present, often accompanied by fibrinoid necrosis of the tunica media and loss of the internal elastic lamina. Immunohistochemical staining showed that many of the infiltrating cells were T lymphocytes and histiocytes, suggesting a cell-mediated component to the pathogenesis.

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Polyarteritis in mice due to spontaneous hypertension

Cited by 12 publications

References 4 publications

The Pathology of Aging 129S6/SvEvTac Mice

The Pathology of Aging 129S6/SvEvTac Mice

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Polyarteritis Nodosa in a Cynomolgus Macaque (Macaca fascicularis)

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