Polyanionic Composite Membranes Based on Bacterial Cellulose and Amino Acid for Antimicrobial Application

Abstract

Ideal wound dressing materials should be active components in the healing process. Bacterial cellulose (BC) has attracted a great deal of attention as novel wound dressing materials; however, it has no intrinsic antimicrobial activity. To explore the practical application values of BC and develop novel wound dressing materials, a series of composite membranes based on BC and polymeric ionic liquids (BC/PILs, composed of BC, and PILs formed by choline and different amino acids) with antimicrobial activity were synthesized by an ex situ method. The physicochemical and antimicrobial properties and biocompatibility of these membranes were systematically investigated. The results indicated that BC/PIL membranes with excellent properties could be obtained by adjusting the concentration and type of PILs. Several kinds of BC/ PIL membranes exhibited good biocompatibility and high antimicrobial activity against Gram-positive and Gram-negative bacteria and fungus. The anionic PILs played important roles in the antimicrobial activity of BC/PIL membranes. The obtained membranes provided a novel promising candidate for wound dressing materials.

Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials

“…Similarly, promising results were obtained with a poly-IL (1-vinyl-3-butylimidazolium bromide)/poly(vinyl alcohol) wound dressing [172], a reusable 1-vinyl-3-butylimidazolium bromide-grafted cotton gauze wound dressing [173], and molecular brushes with 3-(12-mercaptododecyl)-1methylimidazolium bromide [186]. Composite membranes composed of bacterial cellulose and cholinium poly-ILs with amino acid anions were active against Gram-negative and Gram-positive bacteria and fungi [187]. Poly(vinylidene fluoride) (PVDF) materials grafted with ILs (1-vinyl-3-butylimidazolium chloride, 1-vinyl-3-ethylimidazolium tetrafluoroborate) showed activity against both common bacteria and "superbugs" [188].…”

Latest Advances on Bacterial Cellulose-Based Antibacterial Materials as Wound Dressings

“…Lysine, tyrosine, arginine and other bioactive substances can promote cell proliferation and collagen deposition related to skin growth, thus accelerating wound healing, and some amino acids can also obtain antibacterial activity after modification. For the sake of exploring the practical application value of BC and developing new wound dressings, a series of BC/PILs composite membranes with antibacterial activity were synthesized by in situ synthesis method (He et al, 2020). Polymer ionic liquids (PILs) were formed by choline and different amino acids.…”

A Review Of Wound Dressings – Biodegradable Materials

“…The results showed that the anionic PILs exhibit sufficient antimicrobial activity. [14] High capital investment, high operating costs and low yield are the major disadvantage of BC production and focus has to be made to overcome this and thus wound dressings have to be developed with low cost, simple process and no potential toxicity.…”