Polyamines and colon cancer

Wallace, Heather M.; Caslake, Robert

doi:10.1097/00042737-200109000-00006

Cited by 91 publications

(46 citation statements)

References 34 publications

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“…The tumour suppressor adenomatous polyposis coli (APC) is mutated or lost in the germline of individuals with FAP 24,25 and in somatic intestinal epithelial cells that develop into colonic polyps in individuals who are not genetically predisposed to colon cancer 26 . In colon tumour cells, loss of APC function leads to increased expression of the MYC 27 oncogene, aberrant expression are an adequate prognostic marker of cancer 12 . The role of urinary polyamines as a predictive marker for response to therapy remains to be established.…”

Section: Mechanisms Of Polyamine Upregulation In Cancermentioning

confidence: 99%

Polyamines and cancer: old molecules, new understanding

2004

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| The amino-acid-derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism. Inhibition of polyamine synthesis has proven to be generally ineffective as an anticancer strategy in clinical trials, but it is a potent cancer chemoprevention strategy in preclinical studies. Clinical trials, with well-defined goals, are now underway to evaluate the chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues. UREA CYCLEThe key metabolic pathway in mammals for eliminating cellular breakdown products containing nitrogen. NATURE REVIEWS | CANCER VOLUME 4 | OCTOBER 2004 | 7 8 1

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Section: Mechanisms Of Polyamine Upregulation In Cancermentioning

confidence: 99%

Polyamines and cancer: old molecules, new understanding

2004

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“…Colorectal cancer is associated with significant morbidity and mortality in the industrialized world, including the United Kingdom, United States of America and Japan [2][3][4][5]. Age-standardized incidence rates vary from [23][24][25][26][27][28][29][30][31][32][33][34][35] per 100 000 population in North America to 5-15 per 100 000 in the developing countries of Africa and Asia [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Colorectal cancer: case-control study of sociodemographic, lifestyle and anthropometric parameters in Riyadh

Almurshed¹

2009

East Mediterr Health J

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This case-control study compared sociodemographic variables, lifestyle and certain anthropometric parameters of 50 patients hospitalized with colorectal cancer with those of 50 ageand sex-matched controls at a referral hospital in Riyadh. Among cases, females were generally more affected by gastrointestinal symptoms and 4% of male patients had a family history of colorectal cancer. Unlike weight and height, body mass index did not differ between cases and controls, but poor knowledge of high-fibre diets was a significant factor. Regression analysis showed low education level, unemployment and not taking exercise regularly were significant risk factors for colorectal cancer. Better education and awareness of colorectal cancer screening is recommended.Cancer colorectal : une étude cas/témoins des paramètres sociodémographiques, relatifs au mode de vie et anthropométriques à Riyad RÉSUMÉ Cette étude cas/témoins a comparé les variables sociodémographiques, le mode de vie et certains paramètres anthropométriques de 50 malades hospitalisés pour un cancer colorectal, par rapport à 50 témoins appariés sur l'âge et le sexe dans un hôpital de recours de Riyad. Parmi les cas, les femmes étaient généralement plus concernées par les symptômes gastro-intestinaux et 4 % des hommes avaient des antécédents familiaux de cancer colorectal. Contrairement au poids et à la taille, l'indice de masse corporelle n'était pas différent entre les cas et les témoins, mais la méconnaissance des régimes riches en fibres était un facteur significatif. L'analyse de régression a montré que le faible niveau d'instruction, le chômage et le manque d'exercice régulier étaient des facteurs de risque significatifs du cancer colorectal. Il est recommandé de renforcer l'information et la prise de conscience à propos du dépistage du cancer colorectal.

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“…High levels of polyamines are associated with the cell proliferation and the decrease in apoptosis 23 . The content of these compounds in the colorectal tissue with neoplasms can be up to four times higher when compared to the normal tissue 24 , and they can be considered a trustable biomarker for the neoplastic growth 25 .…”

Section: Discussionmentioning

confidence: 99%

Sodium butyrate does not decrease the evolution of precancerous lesions in rats

Silva¹,

Penido²,

Valente³

et al. 2010

Acta Cir. Bras.

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Purpose:To evaluate the preventive effect of sodium butyrate in the appearance of aberrant crypt foci (ACF) in rats after induction with the carcinogen 1,2-dimethylhydrazine (DMH). Methods: Forty Wistar rats were separated into four groups (n=10) distributed as follows: control 1, control 2, butyrate 1 and butyrate 2. The groups control 1 and butyrate 1 remained under experimentation for 4 weeks, while the groups control 2 and butyrate 2 remained for 8 weeks. In the first four weeks, the animals of the control groups received water ad libitum and the animals of the butyrate groups received a sodium butyrate solution (3.4%) ad libitum. Injections of the drug 1,2-dimethylhydrazine were applied during the two first weeks of the experiment in all the animals, concurrently with the application of sodium butyrate. The large intestine of the animals was removed, for the analysis of the ACF and of the content of polyamines. The animal feces were collected for the analysis of the SCFA profile. Results: The spermidine presented a higher concentration in the group butyrate 2 in comparison to the group control 2. There was a significant difference in the concentration value (µmol/mL) of acetate in comparison to the groups control 2 and butyrate 2. Conclusion: The use of sodium butyrate together with the induction of colorectal cancer was not effective in the prevention of the disease progression. Key words: Colonic Neoplasms. Precancerous Conditions. Butyrates. Rats. RESUMO Objetivo:Avaliar o efeito preventivo do butirato de sódio no surgimento de focos de cripta aberrante (FCA) em ratos após a indução com o carcinógeno 1,2-dimetilhidrazina. Métodos: Quarenta ratos foram divididos em quatro grupos, com dez animais em cada. Os grupos controle 1 e butirato 1 ficaram em experimentação por 4 semanas e os grupos controle 2 e butirato 2 por oito semanas. Nas primeiras quatro semanas, os animais dos grupos controle receberam água ad libitum e os animais dos grupos butirato receberam solução de butirato de sódio (3,4%) ad libitum. Em todos os animais foram aplicadas quatro injeções subcutâneas da droga 1,2-dimetilhidrazina nas duas primeiras semanas, concomitante a administração do butirato de sódio. Foi retirado o intestino grosso dos animais, para análise dos FCA e do teor de poliaminas. As fezes dos animais foram recolhidas para análise do perfil de AGCC. Resultados: A espermidina apresentou maior concentração no grupo butirato 2 em relação ao grupo controle 2. Foi encontrada diferença significativa no valor da concentração de acetato quando comparado os grupos controle 2 e butirato 2. Conclusão: A utilização do butirato de sódio concomitante à indução do câncer colorretal não se mostrou efetiva na prevenção da progressão da doença. Descritores: Neoplasias do Colo. Lesões Pré-Cancerosas. Butiratos. Ratos.

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Polyamines and colon cancer

Cited by 91 publications

References 34 publications

Polyamines and cancer: old molecules, new understanding

Polyamines and cancer: old molecules, new understanding

Colorectal cancer: case-control study of sociodemographic, lifestyle and anthropometric parameters in Riyadh

Sodium butyrate does not decrease the evolution of precancerous lesions in rats

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