Polyamidoamine dendrimers-based nanomedicine for combination therapy with siRNA and chemotherapeutics to overcome multidrug resistance

Pan, Jiayi; Mendes, Lívia Palmerston; Yao, Momei; Filipczak, Nina; Garai, Sumanta; Thakur, Ganesh A.; Sarısözen, Can; Torchilin, Vladimir P.

doi:10.1016/j.ejpb.2019.01.006

Cited by 82 publications

(44 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After 4 hrs of treatment, the formulations were removed and replaced with fresh media and cell viability was observed using Cell Titer Blue counted by the plate reader (BioTek) after 24 hrs and 48 hrs of treatment. 33…”

Section: Cell Cytotoxicitymentioning

confidence: 99%

<p>Co-Delivery of Curcumin and Cisplatin to Enhance Cytotoxicity of Cisplatin Using Lipid-Chitosan Hybrid Nanoparticles</p>

Khan¹,

Madni²,

Nawaz³

et al. 2020

IJN

View full text Add to dashboard Cite

Background: Lipid-polymer hybrid nanoparticles (LPHNP) are suitable for co-delivery of hydrophilic and lipophilic drugs. The structural advantages of polymers and biomimetic properties of lipids enable higher encapsulation of drugs and controlled release profile. Lipidpolymer hybrid nanoparticles have been prepared for co-delivery of curcumin and cisplatin for enhanced cytotoxicity against ovarian cancer. Material and Methods: Chitosan, cisplatin, curcumin, Lipoid S75 were selected as structural components and ionic gelation method was used for preparation of LPHNPs. Nanoparticles were formed via ionic interaction of positively charged chitosan and negatively charged lipid. Results: The optimized nanoparticles were of 225 nm with cationic charge. The encapsulation efficiency was greater than 80% with good drug loading. The drug release profile showed controlled release behavior of both curcumin and cisplatin simultaneously and the absence of burst release. The in vitro therapeutic efficacy and cellular association was evaluated using A2780 ovarian cell lines. To further investigate therapeutic efficacy, we developed 3D spheroids as tumor model to mimic the in vivo conditions. The cytotoxicity and uptake of co-loaded LPHNPs were evaluated on 3D spheroids and results indicated increased chemosensitization and enhanced therapeutic efficacy of co-loaded LPHNPs. Conclusion: Lipid-polymer hybrid nanoparticles could be a suitable platform for co-delivery of curcumin and cisplatin for enhanced cytotoxic effect on ovarian cell lines.

show abstract

Section: Cell Cytotoxicitymentioning

confidence: 99%

<p>Co-Delivery of Curcumin and Cisplatin to Enhance Cytotoxicity of Cisplatin Using Lipid-Chitosan Hybrid Nanoparticles</p>

Khan¹,

Madni²,

Nawaz³

et al. 2020

IJN

View full text Add to dashboard Cite

show abstract

“…In fact, several poly-ion complex (PIC) micelles have been designed that incorporate negatively charged biomolecules by electrostatic interaction with positively charged block copolymers [21,27]. In addition, they can be stabilized by the covalent crosslinking of their core through disulfide bonds [28], which can be cleaved under specific intracellular conditions, enabling the complexes to escape from endosomal compartments after endocytosis and to deliver the biomolecules to subcellular destinations [29] without drug degradation. By introducing hydrophobic molecules such as cholesterol to the core [30], PIC micelles become more stable, with a longer half-life in the bloodstream, allowing for the delivery of intact biomolecules to therapeutic targets.…”

Section: Polymeric Nanoparticles (Nps)mentioning

confidence: 99%

Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy

et al. 2020

View full text Add to dashboard Cite

Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, drug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review.

show abstract

“…They also enhance the solubility, stability, and oral bioavailability of many drugs [70]. Recently, Pan et al developed a polyamidoamine dendrimers-based nanomedicine that incorporates a small interfering RNA (siRNA) that can downregulate a multidrug resistance (MDR)-related protein onto the dendrimer in order to overcome multidrug resistance which is frequently encountered in cancer treatments [71]. Such advances in technology bring hope to the future of cancer treatment.…”

Section: Dendrimersmentioning

confidence: 99%

Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems

Kang

2020

Pharmaceutics

103

View full text Add to dashboard Cite

Nanotechnologies have attracted increasing attention in their application in medicine, especially in the development of new drug delivery systems. With the help of nano-sized carriers, drugs can reach specific diseased areas, prolonging therapeutic efficacy while decreasing undesired side-effects. In addition, recent nanotechnological advances, such as surface stabilization and stimuli-responsive functionalization have also significantly improved the targeting capacity and therapeutic efficacy of the nanocarrier assisted drug delivery system. In this review, we evaluate recent advances in the development of different nanocarriers and their applications in therapeutics delivery.

show abstract

Polyamidoamine dendrimers-based nanomedicine for combination therapy with siRNA and chemotherapeutics to overcome multidrug resistance

Cited by 82 publications

References 52 publications

<p>Co-Delivery of Curcumin and Cisplatin to Enhance Cytotoxicity of Cisplatin Using Lipid-Chitosan Hybrid Nanoparticles</p>

<p>Co-Delivery of Curcumin and Cisplatin to Enhance Cytotoxicity of Cisplatin Using Lipid-Chitosan Hybrid Nanoparticles</p>

Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy

Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems

Contact Info

Product

Resources

About