Polyacrylic acid@zeolitic imidazolate framework-8 nanoparticles with ultrahigh drug loading capability for pH-sensitive drug release

Abstract

The polyacrylic acid@zeolitic imidazolate framework-8 (PAA@ZIF-8) nanoparticles (NPs) were first fabricated using a facile and simple route. It is worthwhile noting that the as-fabricated PAA@ZIF-8 NPs possessed ultrahigh doxorubicin (DOX) loading capability (1.9 g DOX g(-1) NPs), which were employed as pH-dependent drug delivery vehicles.

Zeolitic Imidazole Framework (ZIF) Nanospheres for Easy Encapsulation and Controlled Release of an Anticancer Drug Doxorubicin under Different External Stimuli: A Way toward Smart Drug Delivery System

“…As the cavity of the ZIFs frameworks are filled by drug molecules, so they become more rigid and become more thermally 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 13 Therefore, it is clear from IR, UV, TGA and PXRD data that drug is incorporated inside the ZIFs framework. It is noteworthy that although ZIF-8 has been used as a DDS for camptothecin and other drug molecules as reported earlier, [43][44][45] there are no such reports where drug ...…”

Facile fabrication of hollow mesoporous Eu 3+ -doped Gd 2 O 3 nanoparticles for dual-modal imaging and drug delivery

“…HMNPs and the applications in simultaneous fluorescence, MR imaging and drug delivery are presented in Scheme 1. Briefly, the PAAS NPs were firstly synthesized by using a facile and mild route in a deionized water (DI water)-isopropyl alcohol (IPA) (volume ratio = 1:4) system at room temperature [42]. After successively adding Gd(NO 3 ) 3 After calcination at 600 °C for 5h, the PAAS NPs templates were removed, Gd(OH) 3 and Eu(OH) 3 were transferred to Gd 2 O 3 and Eu 2 O 3 after thermal decomposition, resulting in the formation of well-dispersed Eu 3+ -doped Gd 2 O 3 HMNPs.…”

“…2A (a), (b) and (c) show the FT-IR spectra of PAAS NPs, PAA@Gd(OH) 3 /Eu(OH) 3 precursors and Eu 3+ -doped Gd 2 O 3 HMNPs, respectively. The obvious peaks appeared at 1560 and 1410 cm -1 in PAAS NPs and PAA@Gd(OH) 3 /Eu(OH) 3 precursors are assigned to the shift of the C=O bands caused by coordination of -COO -groups and metal cations, qualitativelyindicating the presence of PAA[42]. For Eu 3+ -doped Gd 2 O 3 HMNPs, the band around 1500 cm -1 attributed to -COO -stretching vibration almost disappeared, confirming that the PAAS templates have been removed successfully from the obtained HMNPs.In addition, the peak appeared at 550 cm -1 which results from the Gd-O vibration of cubic Gd 2 O 3 is obviously found from the curve of Eu 3+ -doped Gd 2 O 3 HMNPs[43].The aforementioned results strongly suggest that the PAA@Gd(OH)3 /Eu(OH) 3 precursors have successfully converted to Eu 3+ -doped Gd 2 O 3 HMNPs during the (curve b), which further affirm the transformation from amorphous PAA@Gd(OH) 3 /Eu(OH) 3 precursors to highly crystalline Eu 3+ -doped Gd 2 O 3 HMNPs.…”

Designed preparation of polyacrylic acid/calcium carbonate nanoparticles with high doxorubicin payload for liver cancer chemotherapy

“…2C. The first event is the loss of PAA at a temperature range of 400-440°C, 12 and the second event takes place at a temperature range of 600-750°C, which is consistent with the typical weight loss of CaCO 3 . 13 The XRD pattern of the obtained PAA/CaCO 3 NPs shows no obvious diffraction peak, as shown in Fig.…”