Polyacetylene Glycosides: Isolation, Biological Activities and Synthesis

Santos, Jonh Anderson Macêdo; Santos, Cláudia Laís Araújo Almeida; Filho, João Rufino Freitas; Menezes, Paulo H.; Freitas, Juliano Carlo Rufino

doi:10.1002/tcr.202100176

Cited by 5 publications

(2 citation statements)

References 174 publications

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“…These are grouped according to their synthesis pathway into classes such as alkaloids, flavonoids, and terpenes, among others [ 13 ]. As for glycosides, they are ubiquitous natural products, and due to their structural diversity, they therefore possess many pharmacological activities such as anti-inflammatory, antioxidant, and analgesic effects [ 14 , 15 , 16 ]. In this manuscript, we select 21 glycosides with relatively clear mechanisms and summarize their roles in UC to provide a reference for the drug development of glycoside molecules.…”

Section: Introductionmentioning

confidence: 99%

Glycosides as Potential Medicinal Components for Ulcerative Colitis: A Review

et al. 2023

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Ulcerative colitis (UC) is a chronic, non-specific disease of unknown etiology. The disease develops mainly in the rectum or colon, and the main clinical symptoms include abdominal pain, diarrhea, and purulent bloody stools, with a wide variation in severity. The specific causative factors and pathogenesis of the disease are not yet clear, but most scholars believe that the disease is caused by the interaction of genetic, environmental, infectious, immune, and intestinal flora factors. As for the treatment of UC, medications are commonly used in clinical practice, mainly including aminosalicylates, glucocorticoids, and immunosuppressive drugs. However, due to the many complications associated with conventional drug therapy and the tendency for UC to recur, there is an urgent need to discover new, safer, and more effective drugs. Natural compounds with biodiversity and chemical structure diversity from medicinal plants are the most reliable source for the development of new drug precursors. Evidence suggests that glycosides may reduce the development and progression of UC by modulating anti-inflammatory responses, inhibiting oxidative stress, suppressing abnormal immune responses, and regulating signal transduction. In this manuscript, we provide a review of the epidemiology of UC and the available drugs for disease prevention and treatment. In addition, we demonstrate the protective or therapeutic role of glycosides in UC and describe the possible mechanisms of action to provide a theoretical basis for preclinical studies in drug development.

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Section: Introductionmentioning

confidence: 99%

Glycosides as Potential Medicinal Components for Ulcerative Colitis: A Review

et al. 2023

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“…Natural products, especially plant secondary metabolites are important options for treating different pain conditions, such as alkaloids, flavonoids and glycosides [ 2 , 12 , 13 , 14 ]. As for glycosides, they are ubiquitous natural products, and due to their structural diversity, especially the aglycone part, they have numerous pharmacological activities, such as antinociceptive, neuroprotective, antioxidant and anti-inflammatory effects [ 15 , 16 ]. Evidence also suggests that glycosides can achieve a positive antinociceptive effect on neuropathic pain [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal Components

Tian

Liu

et al. 2021

Molecules

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Neuropathic pain is a refractory disease that occurs across the world and pharmacotherapy has limited efficacy and/or safety. This disease imposes a significant burden on both the somatic and mental health of patients; indeed, some patients have referred to neuropathic pain as being ‘worse than death’. The pharmacological agents that are used to treat neuropathic pain at present can produce mild effects in certain patients, and induce many adverse reactions, such as sedation, dizziness, vomiting, and peripheral oedema. Therefore, there is an urgent need to discover novel drugs that are safer and more effective. Natural compounds from medical plants have become potential sources of analgesics, and evidence has shown that glycosides alleviated neuropathic pain via regulating oxidative stress, transcriptional regulation, ion channels, membrane receptors and so on. In this review, we summarize the epidemiology of neuropathic pain and the existing therapeutic drugs used for disease prevention and treatment. We also demonstrate how glycosides exhibit an antinociceptive effect on neuropathic pain in laboratory research and describe the antinociceptive mechanisms involved to facilitate the discovery of new drugs to improve the quality of life of patients experiencing neuropathic pain.

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Effects of Structural Variations on Antibacterial Properties for Conjugated Diynes Generated through Glaser Hay Couplings

et al. 2022

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Antibiotic resistance is a growing problem facing global societies today. Many new antibiotics are derivatized versions of already existing antibiotics, which allows for antibiotic resistance to arise. To combat this issue, new antibiotics with different core structures need to be elucidated. Asymmetrical polyacetylenes have been isolated from natural products and they have previously been demonstrated to exhibit antimicrobial and antibacterial activity; however, their synthetic preparation has not made them easily amenable to rapid derivatization for SAR studies. Using a combination of solution and solid‐supported chemistries, an array of diynes inspired by a known natural product were prepared and assessed for antibacterial activity. Ultimately, several compounds were identified with improved activity in bacterial viability assays. Moreover, some compounds were discovered that displayed a degree of specificity for E. coli over P. fluorescens and vice versa. These new compounds show promise, and further investigation is needed to pinpoint the specific structural components that elicit biological activity.

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Polyacetylene Glycosides: Isolation, Biological Activities and Synthesis

Cited by 5 publications

References 174 publications

Glycosides as Potential Medicinal Components for Ulcerative Colitis: A Review

Glycosides as Potential Medicinal Components for Ulcerative Colitis: A Review

Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal Components

Effects of Structural Variations on Antibacterial Properties for Conjugated Diynes Generated through Glaser Hay Couplings

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