Poly(ε-caprolactone)/poly(glycerol sebacate) electrospun scaffolds for cardiac tissue engineering using benign solvents

Vogt, Lena; Rivera, Laura Ramos; Liverani, Liliana; Piegat, Agnieszka; Fray, Mirosława El; Boccaccını, Aldo R.

doi:10.1016/j.msec.2019.04.091

Cited by 73 publications

(71 citation statements)

References 45 publications

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“…After production, the samples were stored at room temperature. 13 C at 100.624 MHz) at 293 K. Chemical shifts were expressed as δ in parts per million (ppm) and were adjusted to the chemical shift of the residual NMR solvent resonance peak (CDCl 3 , 1 H: δ = 7.26 ppm).…”

Section: Fabrication Of 3d Printed Scaffoldsmentioning

confidence: 99%

Multi-layer Scaffolds of Poly(caprolactone), Poly(glycerol sebacate) and Bioactive Glasses Manufactured by Combined 3D Printing and Electrospinning

2020

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Three-dimensional (3D) printing has been combined with electrospinning to manufacture multi-layered polymer/glass scaffolds that possess multi-scale porosity, are mechanically robust, release bioactive compounds, degrade at a controlled rate and are biocompatible. Fibrous mats of poly (caprolactone) (PCL) and poly (glycerol sebacate) (PGS) have been directly electrospun on one side of 3D-printed grids of PCL-PGS blends containing bioactive glasses (BGs). The excellent adhesion between layers has resulted in composite scaffolds with a Young’s modulus of 240–310 MPa, higher than that of 3D-printed grids (125–280 MPa, without the electrospun layer). The scaffolds degraded in vitro by releasing PGS and BGs, reaching a weight loss of ~14% after 56 days of incubation. Although the hydrolysis of PGS resulted in the acidification of the buffer medium (to a pH of 5.3–5.4), the release of alkaline ions from the BGs balanced that out and brought the pH back to 6.0. Cytotoxicity tests performed on fibroblasts showed that the PCL-PGS-BGs constructs were biocompatible, with cell viability of above 125% at day 2. This study demonstrates the fabrication of systems with engineered properties by the synergy of diverse technologies and materials (organic and inorganic) for potential applications in tendon and ligament tissue engineering.

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Section: Fabrication Of 3d Printed Scaffoldsmentioning

confidence: 99%

Multi-layer Scaffolds of Poly(caprolactone), Poly(glycerol sebacate) and Bioactive Glasses Manufactured by Combined 3D Printing and Electrospinning

2020

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“…However, among those efforts it is noteworthy to mention studies on the use of benign solvents for the electrospinning of blends containing PGSeb prepolymer and mildly crosslinked prepolymer. Vogt et al reported acetic acid as a solvent for the fabrication of PCL/PGSeb electrospun fibers suitable for soft tissue engineering applications, as cardiac tissue engineering [143]. The microstructure of the electrospun fibers obtained from the blend of PCL and PGSeb in acetic acid is shown in Figure 7.…”

Section: Processingmentioning

confidence: 99%

“…Engelmayr et al explored an accordion-like honeycomb pattern [126] while Neal et al studied two-layers constructs, with anisotropic, interconnected, cubic rectangular, or hexagonal rectangular pores [124]. Ravichandran and his coworkers investigated the use of PGSeb nanofibers [149], while Boccaccini et al were interested in electrospun fibrous scaffolds [143,150,151]. PGSeb fibers could be directly injected into the infarct wall, avoiding the need of more invading surgical procedures and limiting cell loss.…”

Section: Myocardial Tissue Engineeringmentioning

confidence: 99%

“…SEM micrograph of electrospun PCL/PGSeb fibers by using acetic acid as solvent, obtained by the authors following the protocol reported by Vogt et al[143]. Data not previously published.Using PVA nanofibers as a template, Hsu et al reported the fabrication of an anisotropic PGSeb membrane: a sacrificial layer of aligned PVA fibers was immersed in the PGSeb prepolymer and, after curing, removed by water, leaving aligned cylindrical pores in the PGSeb membrane (Figure 6h)…”

mentioning

confidence: 99%

“…SEM micrograph of electrospun PCL/PGSeb fibers by using acetic acid as solvent, obtained by the authors following the protocol reported by Vogt et al[143]. Data not previously published.…”

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Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications

Zamboulis

Nakiou

Christodoulou

et al. 2019

IJMS

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In a century when environmental pollution is a major issue, polymers issued from bio-based monomers have gained important interest, as they are expected to be environment-friendly, and biocompatible, with non-toxic degradation products. In parallel, hyperbranched polymers have emerged as an easily accessible alternative to dendrimers with numerous potential applications. Glycerol (Gly) is a natural, low-cost, trifunctional monomer, with a production expected to grow significantly, and thus an excellent candidate for the synthesis of hyperbranched polyesters for pharmaceutical and biomedical applications. In the present article, we review the synthesis, properties, and applications of glycerol polyesters of aliphatic dicarboxylic acids (from succinic to sebacic acids) as well as the copolymers of glycerol or hyperbranched polyglycerol with poly(lactic acid) and poly(ε-caprolactone). Emphasis was given to summarize the synthetic procedures (monomer molar ratio, used catalysts, temperatures, etc.,) and their effect on the molecular weight, solubility, and thermal and mechanical properties of the prepared hyperbranched polymers. Their applications in pharmaceutical technology as drug carries and in biomedical applications focusing on regenerative medicine are highlighted.

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Poly(Glycerol Sebacate) in Biomedical Applications—A Review of the Recent Literature

Vogt

Ruther

Salehi

et al. 2021

Adv Healthcare Materials

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102

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Poly(glycerol sebacate) (PGS) continues to attract attention for biomedical applications owing to its favorable combination of properties. Conventionally polymerized by a two‐step polycondensation of glycerol and sebacic acid, variations of synthesis parameters, reactant concentrations or by specific chemical modifications, PGS materials can be obtained exhibiting a wide range of physicochemical, mechanical, and morphological properties for a variety of applications. PGS has been extensively used in tissue engineering (TE) of cardiovascular, nerve, cartilage, bone and corneal tissues. Applications of PGS based materials in drug delivery systems and wound healing are also well documented. Research and development in the field of PGS continue to progress, involving mainly the synthesis of modified structures using copolymers, hybrid, and composite materials. Moreover, the production of self‐healing and electroactive materials has been introduced recently. After almost 20 years of research on PGS, previous publications have outlined its synthesis, modification, properties, and biomedical applications, however, a review paper covering the most recent developments in the field is lacking. The present review thus covers comprehensively literature of the last five years on PGS‐based biomaterials and devices focusing on advanced modifications of PGS for applications in medicine and highlighting notable advances of PGS based systems in TE and drug delivery.

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Poly(ε-caprolactone)/poly(glycerol sebacate) electrospun scaffolds for cardiac tissue engineering using benign solvents

Cited by 73 publications

References 45 publications

Multi-layer Scaffolds of Poly(caprolactone), Poly(glycerol sebacate) and Bioactive Glasses Manufactured by Combined 3D Printing and Electrospinning

Multi-layer Scaffolds of Poly(caprolactone), Poly(glycerol sebacate) and Bioactive Glasses Manufactured by Combined 3D Printing and Electrospinning

Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications

Poly(Glycerol Sebacate) in Biomedical Applications—A Review of the Recent Literature

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