Poly(ε-benzyloxycarbonyl-L-lysine)-grafted branched polyethylenimine as efficient nanocarriers for indomethacin with enhanced oral bioavailability and anti-inflammatory efficacy

Lü, Chao; Li, Xin; Xia, Wenquan; Lu, Siheng; Liu, Hongjun; Ye, Danyan; Zhang, Yanmei; Liu, Daojun

doi:10.1016/j.actbio.2016.11.038

Cited by 27 publications

(18 citation statements)

References 33 publications

(56 reference statements)

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“…Several studies showed that amines in nanoparticle, such as poly L-glutamic acid derivatives, can affect the toxicity [45,46,47]. On the contrary to these studies, we did not observe the hemolytic activity on red blood cells though it contains amine group.…”

Section: Discussioncontrasting

confidence: 98%

Synthesis, characterization and toxicity assessment of a new polymeric nanoparticle, l-glutamic acid-g-p(HEMA)

Bakan

Gülcemal

Akgöl

et al. 2020

Chemico-Biological Interactions

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Section: Discussioncontrasting

confidence: 98%

Synthesis, characterization and toxicity assessment of a new polymeric nanoparticle, l-glutamic acid-g-p(HEMA)

Bakan

Gülcemal

Akgöl

et al. 2020

Chemico-Biological Interactions

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“…In the first step, ZLL-NCA was prepared via phosgenation of ZLL in anhydrous ethyl acetate (Yield: 78%) and then polymerized using PEI as the macroinitiator to obtain the star-block copolymers PEZ (Yield: 92%) according to our previous report [16,24,28,30].…”

Section: Synthesis and Characterization Of Mpll-alt-peg Copolymersmentioning

confidence: 99%

“…The PEG-crosslinked alternating copolymers MPLL-alt-PEG with a multi-armed PLL polyelectrolyte segment, were designed and synthesized. As demonstrated in Figure 1, PEZ was firstly synthesized through ring-opening polymerization of ZLL-NCA using PEI (Mw = 0.8 kDa) with eight peripheral primary amines as a macroinitiator [30]. Subsequently, difunctional SCM-PEG-SCM was introduced to crosslink PEZ and then the crosslinked product PEZ-alt-PEG was obtained under optimized crosslinking conditions [28].…”

Section: Synthesis and Characterization Of Mpll-alt-peg Copolymersmentioning

confidence: 99%

Poly(Ethylene Glycol) Crosslinked Multi-Armed Poly(l-Lysine) with Encapsulating Capacity and Antimicrobial Activity for the Potential Treatment of Infection-Involved Multifactorial Diseases

et al. 2020

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With the development of modern medical technology, common diseases usually can be treated by traditional medicines and their formulation, while diseases with multiple etiologies still remain a great challenge in clinic. Nanoformulation was widely explored to address this problem. However, due to limited drug loading space of nanocarriers, co-delivery strategy usually fails to achieve sufficient loading of multiple drugs simultaneously. In this research, we explored the potential of poly(ethylene glycol) (PEG) crosslinked alternating copolymers MPLL-alt-PEG as both an anionic drug carrier and antimicrobial agent. The high cationic charge density of multi-armed poly(l-lysine) (MPLL) segments in MPLL-alt-PEG could endow the electrostatic encapsulation of anionic model drugs through the formation of polyion complex micelles with a MPLL/drug complex core and crosslinked PEG outer shell, enabling pH-sensitive drug release. Meanwhile, the MPLL-alt-PEG copolymer exhibits a broad spectrum of antimicrobial activities against various clinically relevant microorganisms with low hemolytic activity. Studies on antibacterial mechanism revealed that MPLL-alt-PEG attacked bacteria through the membrane disruption mechanism which is similar to that of typical antimicrobial peptides. Taken together, the present study shed light on the possibility of endowing a polymeric carrier with therapeutic effect and thus offered a promising strategy for achieving a comprehensive treatment of bacterial infection-involved multifactorial diseases.

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“…Experimental intestinal IRI is induced by clamping the superior mesenteric artery alone or with the portal vein for a period of 30 min to 2 h, followed by reperfusion . An intestinal IRI model was (Figure ) successfully employed to study novel polymeric nanocarriers for potentially toxic and poorly water‐soluble pharmaceutical agents, such as indomethacin and simvastatin …”

Section: Animal Models For Studying Cell‐assisted Drug Deliverymentioning

confidence: 99%

Cell‐Based Drug Delivery and Use of Nano‐and Microcarriers for Cell Functionalization

Timin

Litvak

Gorin

et al. 2017

Adv Healthcare Materials

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Cell functionalization with recently developed various nano- and microcarriers for therapeutics has significantly expanded the application of cell therapy and targeted drug delivery for the effective treatment of a number of diseases. The aim of this progress report is to review the most recent advances in cell-based drug vehicles designed as biological transporter platforms for the targeted delivery of different drugs. For the design of cell-based drug vehicles, different pathways of cell functionalization, such as covalent and noncovalent surface modifications, internalization of carriers are considered in greater detail together with approaches for cell visualization in vivo. In addition, several animal models for the study of cell-assisted drug delivery are discussed. Finally, possible future developments and applications of cell-assisted drug vehicles toward targeted transport of drugs to a designated location with no or minimal immune response and toxicity are addressed in light of new pathways in the field of nanomedicine.

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Poly(ε-benzyloxycarbonyl-L-lysine)-grafted branched polyethylenimine as efficient nanocarriers for indomethacin with enhanced oral bioavailability and anti-inflammatory efficacy

Cited by 27 publications

References 33 publications

Synthesis, characterization and toxicity assessment of a new polymeric nanoparticle, l-glutamic acid-g-p(HEMA)

Synthesis, characterization and toxicity assessment of a new polymeric nanoparticle, l-glutamic acid-g-p(HEMA)

Poly(Ethylene Glycol) Crosslinked Multi-Armed Poly(l-Lysine) with Encapsulating Capacity and Antimicrobial Activity for the Potential Treatment of Infection-Involved Multifactorial Diseases

Cell‐Based Drug Delivery and Use of Nano‐and Microcarriers for Cell Functionalization

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