Poly(Ethylene Glycol) Crosslinked Multi-Armed Poly(l-Lysine) with Encapsulating Capacity and Antimicrobial Activity for the Potential Treatment of Infection-Involved Multifactorial Diseases

Lü, Chao; Wen, Ting; Zheng, Maochao; Liu, Daojun; Quan, Guilan; Pan, Xin; Wu, Chuanbin

doi:10.3390/pharmaceutics12010047

Cited by 16 publications

(10 citation statements)

References 41 publications

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“…Nanoparticles and self-assembling compounds are currently being explored as not only delivery vehicles, but as compounds that also have inherent antibacterial properties. One such example are the previously mentioned star-shaped PLL molecules (also known as multi-armed poly (ʟ-lysine) (MPLL) molecules) which can be crosslinked with poly (ethylene glycol) (PEG) (MPLL- alt -PEG) ( Lu et al, 2020 ). The MPLL polymer is positively charged, allowing it to disrupt bacterial membranes, and when crosslinked with PEG can encapsulate negatively charged drugs and self-assemble into micelles.…”

Section: Multi-unit Materials With Antimicrobial Activitymentioning

confidence: 99%

The Potential of Modified and Multimeric Antimicrobial Peptide Materials as Superbug Killers

Matthyssen¹,

Li²,

Holden³

et al. 2022

Front. Chem.

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Antimicrobial peptides (AMPs) are found in nearly all living organisms, show broad spectrum antibacterial activity, and can modulate the immune system. Furthermore, they have a very low level of resistance induction in bacteria, which makes them an ideal target for drug development and for targeting multi-drug resistant bacteria ‘Superbugs’. Despite this promise, AMP therapeutic use is hampered as typically they are toxic to mammalian cells, less active under physiological conditions and are susceptible to proteolytic degradation. Research has focused on addressing these limitations by modifying natural AMP sequences by including e.g., d-amino acids and N-terminal and amino acid side chain modifications to alter structure, hydrophobicity, amphipathicity, and charge of the AMP to improve antimicrobial activity and specificity and at the same time reduce mammalian cell toxicity. Recently, multimerisation (dimers, oligomer conjugates, dendrimers, polymers and self-assembly) of natural and modified AMPs has further been used to address these limitations and has created compounds that have improved activity and biocompatibility compared to their linear counterparts. This review investigates how modifying and multimerising AMPs impacts their activity against bacteria in planktonic and biofilm states of growth.

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Section: Multi-unit Materials With Antimicrobial Activitymentioning

confidence: 99%

The Potential of Modified and Multimeric Antimicrobial Peptide Materials as Superbug Killers

Matthyssen¹,

Li²,

Holden³

et al. 2022

Front. Chem.

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“…In addition to excellent lamination release and dissolution effects, MNs should have good biocompatibility, which is a prerequisite for biomedical materials. 50 Hence, the in vitro compatibility of the HAMA-HA-PVP MNs was evaluated by testing their cytotoxic effects on human oral keratinocyte (HOK) cells, a type of human oral epithelial cell. Figure 8a shows the proliferation of HOK cells at different HAMA-HA-PVP MN concentrations (0, 0.125, 0.25, 0.5, 1, 2, and 4 mg/mL).…”

Section: Mechanical Strength Analysis and Insertion Ability Of Hama-h...mentioning

confidence: 99%

Novel Double-Layer Dissolving Microneedles for Transmucosal Sequential Delivery of Multiple Drugs in the Treatment of Oral Mucosa Diseases

Yang

et al. 2023

ACS Appl. Mater. Interfaces

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The development of transmucosal drug delivery systems is a practical requirement in oral clinical practice, and controlled sequential delivery of multiple drugs is usually required. On the basis of the previous successful construction of monolayer microneedles (MNs) for transmucosal drug delivery, we designed transmucosal double-layer sequential dissolving MNs using hyaluronic acid methacryloyl (HAMA), hyaluronic acid (HA), and polyvinyl pyrrolidone (PVP). MNs have the advantages of small size, easy operation, good strength, rapid dissolution, and one-time delivery of two drugs. Morphological test results showed that the HAMA-HA-PVP MNs were small and intact in structure. The mechanical strength and mucosal insertion test results indicated the HAMA-HA-PVP MNs had appropriate strength and could penetrate the mucosal cuticle quickly to achieve transmucosal drug delivery. The in vitro and in vivo experiment results of the double-layer fluorescent dyes simulating drug release revealed that MNs had good solubility and achieved stratified release of the model drugs. The results of the in vivo and in vitro biosafety tests also indicated that the HAMA-HA-PVP MNs were biosafe materials. The therapeutic effect of drug-loaded HAMA-HA-PVP MNs in the rat oral mucosal ulcer model demonstrated that these novel HAMA-HA-PVP MNs quickly penetrated the mucosa, dissolved and effectively released the drug, and achieved sequential drug delivery. Compared to monolayer MNs, these HAMA-HA-PVP MNs can be used as double-layer drug reservoirs for controlled release, effectively releasing the drug in the MN stratification by dissolution in the presence of moisture. The need for secondary or multiple injections can be avoided, thus improving patient compliance. This drug delivery system can serve as an efficient, multipermeable, mucosal, and needle-free alternative for biomedical applications.

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“…Moreover, P2 was expected to be a better pathogen antagonist than P1. PEG (polyethylene glycol) based polymers exhibit a broad spectrum of antimicrobial activities and are employed as long-lasting antimicrobial surface coatings able to reduce the adhesion of bacteria [69][70][71][72][73].…”

Section: Chemistry Of the Grafted Polymersmentioning

confidence: 99%

AIEgen orthopalladated hybrid polymers for efficient inactivation of the total coliforms in urban wastewater

Sessa

Diana

Gentile

et al. 2023

Preprint

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Monitorable AIE polymers with a bioactive pattern are employed in advanced biomedical applications such as functional coatings, theranostic probes, and implants. After the global COVID-19 pandemic, interest in developing surfaces with superior antimicrobial, antiproliferative, and antiviral activities dramatically increased. Many formulations for biocide surfaces are based on hybrid organic/inorganic materials. Palladium (II) complexes display relevant activity against common bacteria, even higher when compared to their uncoordinated ligands. This article reports the design and synthesis of two series of orthopalladated polymers obtained by grafting a cyclopalladated fragment on two different O, N chelating Schiff base polymers. Different grafting percentages were examined and compared for each organic polymer. The fluorescence emission in the solid state was explored on organic matrixes and grafted polymers. DFT analysis provided a rationale for the role of the coordination core. The antibacterial response of the two series of hybrid polymers was tested against the total coliform group of untreated urban wastewater, revealing excellent inactivation ability.

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Poly(Ethylene Glycol) Crosslinked Multi-Armed Poly(l-Lysine) with Encapsulating Capacity and Antimicrobial Activity for the Potential Treatment of Infection-Involved Multifactorial Diseases

Cited by 16 publications

References 41 publications

The Potential of Modified and Multimeric Antimicrobial Peptide Materials as Superbug Killers

The Potential of Modified and Multimeric Antimicrobial Peptide Materials as Superbug Killers

Novel Double-Layer Dissolving Microneedles for Transmucosal Sequential Delivery of Multiple Drugs in the Treatment of Oral Mucosa Diseases

AIEgen orthopalladated hybrid polymers for efficient inactivation of the total coliforms in urban wastewater

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