Poly(Vinyl Alcohol) Enhances Acetylation of Ascorbic Acid in Superparamagnetic Graphene Oxide Nanoparticles Ultrasonically Complexed with Acetylsalicylic Acid

Abstract

A single-step ultrasonic method (20 kHz) is demonstrated for the formation of acetylsalicylic acid-Fe3O4-graphene oxide nanocomposites (∼80 nm) in aqueous solution. The electronic molecular structure of these nanocomposites is stable in acidic or basic aqueous medium. Coating of these nanocomposites with poly­(vinyl alcohol) (PVA) occurs through increased binding with drug, magnetite, Fe­(II)–C–O and carbonaceous network of graphene oxide. PVA-coated-acetylsalicylic acid-Fe3O4-GO nanocomposites substantially improve acetylation of pristine ascorbic acid than free unmodified drug or uncoated acetylsalicylic acid-Fe3O4-GO nanoparticles because of enhanced electron density through the presence of magnetite and graphene oxide, and specific binding of PVA with drug and ascorbic acid.

Fenton-Hydroxyl Radical Antioxidant Efficiency of Ibuprofen-Fe3O4-GO Nanospheres

“…As Fe 3 O 4 -GO exhibits peroxidase-like activity, it can be potentially applied as a nanozyme . At present Fe 3 O 4 -GO has been produced for loading with various drugs such as doxorubicin, 5-fluorouracil, camptothecin and methotrexate and ultrasonic (20 kHz) functionalization of ketorolac and acetylsalicylic acid (ASA) . Iron-based drugs are of special interest because Fe is a transition metal, which has multiple stable oxidation states and its redox chemistry can be accurately controlled .…”

“…20 At present Fe 3 O 4 -GO has been produced for loading with various drugs such as doxorubicin, 21 5-fluorouracil, 22 camptothecin and methotrexate 23 and ultrasonic (20 kHz) functionalization of ketorolac 24 and acetylsalicylic acid (ASA). 25 Iron-based drugs are of special interest because Fe is a transition metal, which has multiple stable oxidation states and its redox chemistry can be accurately controlled. 26 However, only a few iron-based drugs (e.g., Proferdex, Dexferrum, InFeD, Venofer) are in clinical trials because the exact molecular mechanisms of their function and catalytic activity are not fully understood in the biological environment.…”

Ultrasonic Formation of Fe3O4-Reduced Graphene Oxide–Salicylic Acid Nanoparticles with Switchable Antioxidant Function

“…In these studies, Fe 3 O 4 NPs are either grown or coated with GO that is loaded with anticancer drugs. Previously, we have introduced a new approach based on the ultrasonic complexation of pristine NSAIDs–ketorolac or aspirin with preformed Fe 3 O 4 NPs grown on GO. , GO especially stands out here as it provides more binding sites for complexation with drugs and improves the electronic properties and stability of potential pharmaceutical compounds. As an advantage, ultrasound causes efficient complexation of drug molecules in NPs so that the structure of pharmaceutical organic ligands does not undergo severe damage and remain stable during the synthesis.…”

Potent E. coli M-17 Growth Inhibition by Ultrasonically Complexed Acetylsalicylic Acid–ZnO–Graphene Oxide Nanoparticles

“…Superparamagnetic Fe 3 O 4 –graphene–ketorolac nanoparticles enabled drug extraction at pHs 1 and 5 being controlled by the H-bond formation and Fe 3 O 4 , and at pH 8predominantly via interaction with GO. Recently we have demonstrated that poly­(vinyl alcohol) can enhance acetylation of ascorbic acid in superparamagnetic-GO NPs ultrasonically complexed with ASA in relation to free unmodified drug or uncoated ASA–Fe 3 O 4 –GO NPs due to enhanced electron density through the presence of magnetite and GO, and specific binding of polymer with drug and ascorbic acid . The surface composition and electronic molecular structure of ASA–GO-coated CuO and diclofenac-GO-coated CuO nanoparticles can be modified at pH from 1 to 8 through the specific interactions involving Cu–O, C–H, and H-bond formation with the carboxylic and carbonyl groups of ASA, diclofenac, and GO.…”