Poly(vinyl alcohol) as a novel constituent to form aqueous two-phase systems with acetonitrile: Phase diagrams and partitioning experiments

Measurement and Correlation of Phase Equilibria in Aqueous Two-Phase Systems Containing Polyoxyethylene Cetyl Ether and Three Organic Salts at Different Temperatures

“…As a new green separation/enrichment technology, the aqueous two-phase extraction (ATPE) has many advantages, for example, being easy to operate, timesaving, highly efficient, green, and environmental friendly. ATPE has been applied in fields ranging from the quantitative separation and extraction of metal ions − and the separation and purification of active biosubstance − to the extraction of natural products. − Currently, the aqueous two-phase system (ATPS) falls into four categories: polymer–salt ATPS, − two-polymer ATPS, , micromolecule alcohol–salt ATPS, , and ion liquid–salt ATPS. , The last three kinds of ATPSs are hard to convert from the laboratory prototype into mass production for the following reasons. First, the viscosity of the two-polymer system is high.…”

Acetonitrile and Na+ or K+ Salts as Constituents of the Aqueous Two-Phase System: Equilibrium Data and Capsaicin Purification

“…The tie-lines (TLs) were measured according to the gravimetric method report by our group in the literature. ,− Briefly, the mixing points located in the biphasic region of the diagram were chosen and the solutions were prepared, vigorously stirred, and centrifuged at 3000g for 10 min. After the system reached the thermodynamic equilibrium (at 298.15 ± 1.00 K for at least 4 h), the top and bottom phases were separated and weighed.…”

“…Besides the alcohols, other organic solvents have been used in ATPSs such as tetrahydrofuran , and acetonitrile (ACN). , ACN (methyl cyanide, C 2 H 3 N) is an aprotic solvent with a high dielectric constant, is miscible in water at all ratios, presents low viscosity, and does not interact strongly with itself. , …”

“…10,11 Besides the alcohols, other organic solvents have been used in ATPSs such as tetrahydrofuran 12,13 and acetonitrile (ACN). 14,15 ACN (methyl cyanide, C 2 H 3 N) is an aprotic solvent with a high dielectric constant, is miscible in water at all ratios, presents low viscosity, and does not interact strongly with itself. 16,17 Several biomolecules have been partitioned/purified using ATPSs, such as enzymes, 18,19 alkaloids, 20,21 dyes, 22,23 antibodies, 24,25 antibiotics, 26,27 and recently, capsaicin (CPS).…”