Poly(trimethylene carbonate) and poly(D,L-lactic acid) modify human dendritic cell responses to staphylococci but do not affect Th1 and Th2 cell development

Balraadjsing, Payal P.S.; Jong, Esther C. de; Grijpma, Dirk W.; Tanck, Michael W.T.; Zaat, S. A. J.

doi:10.22203/ecm.v035a08

Cited by 9 publications

(8 citation statements)

References 53 publications

(36 reference statements)

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“…Likely, APCs are already impaired by the implant and contribute to the immune compromised environment and increased bacterial colonization. Two biodegradable and biocompatible materials that are known to provoke a normal foreign body response were tested for DC activation and subsequent DC-mediated T cell proliferation and polarization in the presence or absence of S. aureus and S. epidermidis , respectively (103). The authors found that the biomaterials alone did not induce DC activation and subsequent DC-mediated T cell activation, but in combination with bacteria, DCs had a slightly changed cytokine secretion profile.…”

Section: Immune Response Against Chronic Implant-related Bone Infectionsmentioning

confidence: 99%

Chronic Implant-Related Bone Infections—Can Immune Modulation be a Therapeutic Strategy?

2019

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Chronic implant-related bone infections are a major problem in orthopedic and trauma-related surgery with severe consequences for the affected patients. As antibiotic resistance increases in general and because most antibiotics have poor effectiveness against biofilm-embedded bacteria in particular, there is a need for alternative and innovative treatment approaches. Recently, the immune system has moved into focus as the key player in infection defense and bone homeostasis, and the targeted modulation of the host response is becoming an emerging field of interest. The aim of this review was to summarize the current knowledge of impaired endogenous defense mechanisms that are unable to prevent chronicity of bone infections associated with a prosthetic or osteosynthetic device. The presence of foreign material adversely affects the immune system by generating a local immune-compromised environment where spontaneous clearance of planktonic bacteria does not take place. Furthermore, the surface structure of the implant facilitates the transition of bacteria from the planktonic to the biofilm stage. Biofilm formation on the implant surface is closely linked to the development of a chronic infection, and a misled adaption of the immune system makes it impossible to effectively eliminate biofilm infections. The interaction between the immune system and bone cells, especially osteoclasts, is extensively studied in the field of osteoimmunology and this crosstalk further aggravates the course of bone infection by shifting bone homeostasis in favor of bone resorption. T cells play a major role in various chronic diseases and in this review a special focus was therefore set on what is known about an ineffective T cell response. Myeloid-derived suppressor cells (MDSCs), anti-inflammatory macrophages, regulatory T cells (T reg s) as well as osteoclasts all suppress immune defense mechanisms and negatively regulate T cell-mediated immunity. Thus, these cells are considered to be potential targets for immune therapy. The success of immune checkpoint inhibition in cancer treatment encourages the transfer of such immunological approaches into treatment strategies of other chronic diseases. Here, we discuss whether immune modulation can be a therapeutic tool for the treatment of chronic implant-related bone infections.

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Section: Immune Response Against Chronic Implant-related Bone Infectionsmentioning

confidence: 99%

Chronic Implant-Related Bone Infections—Can Immune Modulation be a Therapeutic Strategy?

2019

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“…147 Another study found that biomaterials with the presence of bacteria can induce DCs to secrete cytokines, and subsequent T-cell activation is mediated by DCs. 148 Uzhviyuk et al explored the influence of GO nanoparticles on the differentiation of human DCs. 149 It was found that GO had no notable effect on the viability and percentage of DCs in the culture medium.…”

Section: Dendritic Cellsmentioning

confidence: 99%

Graphene and its derivatives: “one stone, three birds” strategy for orthopedic implant-associated infections

Huang

Zhong

et al. 2023

Biomater. Sci.

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“…Although chemical coating or surface modifications can indeed modulate DC maturation, [68,69] biomaterial-regulation of DCs has not yet shown effectiveness in altering T cell responses to Staphylococci. [39,70,71]…”

Section: Host Immune Response To Biomaterials Infectionmentioning

confidence: 99%

Combating Implant Infections: Shifting Focus from Bacteria to Host

et al. 2020

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commensal skin bacteria, Staphylococci, and in particular Staphylococcus aureus, have a strong tendency to colonize foreign bodies and cause IAI. [3,4] Important for the underlying pathophysiology, Staphylococci are highly competent at producing biofilms on implant surfaces, which encapsulate the bacterial niche from the outside environment, [5,6] thereby protecting the bacteria from host defense systems and antibiotics. [7] Antibiotics are administered as a routine procedure. [8] However, as a consequence of widespread antibiotics usage, bacteria are exposed to subinhibitory concentrations of antibiotics at a larger scale, driving their development toward antibiotic resistance, [9] as illustrated by the emergence of methicillin-resistant S. aureus (MRSA). [10,11] As an improvement over current clinically applied local antibiotics delivery systems, [12] the recent developments in implant surface engineering approaches allow better antimicrobial functionalities to be incorporated to allow for more tunable and controlled drug release. [13-15] The "race to the surface" model is popular among biomaterials researchers to predict the biomaterials fate, resulting from the competition between eukaryotic cells and bacteria at the material surface. [16] Using this template, implant antibacterial properties are being stemmed from direct contact killing mechanisms due to implant surface modifications [17,18] or firm immobilization of drugs, [19,20] as they both "shield" the implant from bacterial adhesion. The current anti-infective biomaterials strategies being explored can be categorized as: 1) implant functionalization with antibiotics or antibacterial drugs such as host defense peptides (HDPs), inorganic materials (e.g., chitosan and derivatives), and inorganics (e.g., silver, copper, and zinc metal nanoparticles (NPs)), 2) anti-biofilm surface modification (e.g., coating with antifouling polymers or quorum sensor inhibitors), or 3) physical surface changes for direct contact-killing properties (e.g., nanotubes, nanopillars, and metal implantation). [15,21] Emerging as a serious alternative or adjuvant therapy to antibiotics, bacteriophage (phage) therapy uses viruses responsible for the lysis of specific bacterial strains. [22,23] As a natural predator of bacteria, phages employ different killing mechanisms, making multidrug resistant bacteria susceptible for phages. [24] Moreover, phages are highly specific for pathogenic cells, which can eliminate disastrous off-target effects in the host. [25] As a limitation, the use of phage cocktails is needed for therapeutic efficacy, [26] while there is currently is no conclusive data on possible long-term side effects of phage therapy in The widespread use of biomaterials to support or replace body parts is increasingly threatened by the risk of implant-associated infections. In the quest for finding novel anti-infective biomaterials, there generally has been a one-sided focus on biomaterials with direct antibacterial properties, which leads to excessive use of antibacterial ag...

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Poly(trimethylene carbonate) and poly(D,L-lactic acid) modify human dendritic cell responses to staphylococci but do not affect Th1 and Th2 cell development

Cited by 9 publications

References 53 publications

Chronic Implant-Related Bone Infections—Can Immune Modulation be a Therapeutic Strategy?

Chronic Implant-Related Bone Infections—Can Immune Modulation be a Therapeutic Strategy?

Graphene and its derivatives: “one stone, three birds” strategy for orthopedic implant-associated infections

Combating Implant Infections: Shifting Focus from Bacteria to Host

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