Poly(N-isopropylacrylamide-co-N-t-butylacrylamide)-block-poly(ethylene glycol)-block-poly(N-isopropylacrylamide-co-N-t-butylacrylamide) triblock copolymers: synthesis and thermogelation properties of aqueous solutions

Negru, Ioana; Teodorescu, Mircea; Stănescu, Paul Octavian; Drăghici, Constantin; Lungu, Anamaria; Sârbu, Andrei

doi:10.1007/s00396-013-2994-x

Cited by 8 publications

(8 citation statements)

References 53 publications

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“…Similarly, Pluronic F127 has a reported sol–gel transition (14–40 °C) that is dependent upon concentration, but has T cp above 100 °C . These findings stand in contrast to the PNiPAAm‐ block ‐PEO‐ block ‐PNiPAAm triblock copolymers studied by Teodorescu and co‐workers, wherein the cloud point measurements and the vial inversion gelation temperatures occurred at similar temperatures …”

Section: Resultsmentioning

confidence: 71%

Tunable temperature‐ and shear‐responsive hydrogels based on poly(alkyl glycidyl ether)s

Fellin

Adelmund

Karis

et al. 2018

Polymer International

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We describe the synthesis, characterization and direct-write 3D printing of triblock copolymer hydrogels that have a tunable response to temperature and shear stress. In aqueous solutions, these polymers utilize the temperature-dependent self-association of poly(alkyl glycidyl ether) 'A' blocks and a central poly(ethylene oxide) segment to create a physically crosslinked three-dimensional network. The temperature response of these hydrogels was dependent upon composition, chain length and concentration of the 'A' block in the copolymer. Rheological experiments confirmed the existence of sol-gel transitions and the shear-thinning behavior of the hydrogels. The temperature-and shear-responsive properties enabled direct-write 3D printing of complex objects with high fidelity. Hydrogel cytocompatibility was also confirmed by incorporating HeLa cells into select hydrogels resulting in high viabilities over 24 h. The tunable temperature response and innate shear-thinning properties of these hydrogels, coupled with encouraging cell viability results, present an attractive opportunity for additive manufacturing and tissue engineering applications.

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Section: Resultsmentioning

confidence: 71%

Tunable temperature‐ and shear‐responsive hydrogels based on poly(alkyl glycidyl ether)s

Fellin

Adelmund

Karis

et al. 2018

Polymer International

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“…However, its incidence can be demonstrated by rheometry too, the rheological measurements of such thermosensitive polymers aqueous solutions as a function of temperature showing an increase of viscosity and elastic (G 0 ) and viscous (G 00 ) moduli around T ph [18][19][20]42], followed by a sharp decrease of these parameters when demixing occurs [20]. If viscosity, G 0 and G 00 reach a maximum, and then decrease relatively slowly with increasing temperature, this is indicative for the formation of a more stable gel, displaying demixing after longer time intervals [20].…”

Section: Resultsmentioning

confidence: 98%

“…It was very much studied, especially for biomedical purposes, due to the LCST close to body temperature (about 32 C), abrupt thermal response and low sensitivity to slight modifications of pH, concentration or chemical environment [14,15]. However, PNIPAM aqueous gels [16], as well as some of its block copolymers [17][18][19] and other polymer gels [20], undergo demixing=syneresis (i.e., conversion to a shrunken gel and a low viscosity aqueous phase), on or soon after gelation, due to the increased hydrophobic character of the polymer above T ph , which is an important drawback when applications as injectable hydrogels are targeted [13,16,21].…”

Section: Introductionmentioning

confidence: 99%

Novel Thermoreversible Injectable Hydrogel Formulations Based on Sodium Alginate and Poly(N-Isopropylacrylamide)

Teodorescu

Mihai

Turturicǎ

et al. 2015

International Journal of Polymeric Materials and Polymeric Biom

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Novel injectable thermoreversible hydrogel compositions with semi-interpenetrating network structure were prepared through the addition of sodium alginate (SA) to poly(N-isopropylacrylamide) (PNIPAM) aqueous solutions. The addition of the hydrophilic alginate strongly improved the stability against syneresis of the 15 wt% PNIPAM hydrogels formed at 37 C from less than 15 min in the absence of alginate to more than 7 days in the presence of 4 wt% SA. Besides the SA concentration, the hydrogel stability depended on the molecular weight and polydispersity of PNIPAM, being lower when a high molecular weight fraction was present. The phase transition temperature (T ph ) of the PNIPAM aqueous solutions decreased with alginate concentration, while the dynamic viscosity and elastic modulus of the hydrogels increased. By decreasing the PNIPAM molecular weight and polydispersity, the dynamic viscosity and elastic modulus of the PNIPAM-alginate hydrogels formed above T ph diminished, while their viscoelastic behavior changed from predominantly elastic to predominantly viscous.

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“…Although the values of the molecular weight from Table 1 are not the “absolute values” because of the calibration with a polystyrene standard, 21 the results are extremely useful because they show the molecular weight distribution D of the samples and they make possible the comparison between samples regarding the molecular weight.…”

Section: Resultsmentioning

confidence: 99%

Advanced studies on synthesis and cure reaction of fluorinated epoxy resin

Damian

Vulcan

Zaharia

et al. 2016

High Performance Polymers

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Fluorinated epoxy resins (FERs) were extensively studied for applications in electronic packaging, optical waveguides, and antifouling coatings. This research focuses on the synthesis and characterization of FER following a polycondensation reaction between fluorinated bisphenol and epichlorohydrin. Cure reaction was monitored using dispersive Raman spectroscopy and by calculation of the oxirane groups conversion. After one short postcuring stage, the decomposition temperatures of fluoroepoxy showed increased values with 28–35°C for the samples cured at 50°C. The resultant materials showed excellent fracture morphology, while the presence of fluorine was revealed by energy-dispersive X-ray and X-ray photoelectron spectroscopic techniques. Hydrophobic surface was evidenced through the surface energy resulted from contact angle measurements.

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Poly(N-isopropylacrylamide-co-N-t-butylacrylamide)-block-poly(ethylene glycol)-block-poly(N-isopropylacrylamide-co-N-t-butylacrylamide) triblock copolymers: synthesis and thermogelation properties of aqueous solutions

Cited by 8 publications

References 53 publications

Tunable temperature‐ and shear‐responsive hydrogels based on poly(alkyl glycidyl ether)s

Tunable temperature‐ and shear‐responsive hydrogels based on poly(alkyl glycidyl ether)s

Novel Thermoreversible Injectable Hydrogel Formulations Based on Sodium Alginate and Poly(N-Isopropylacrylamide)

Advanced studies on synthesis and cure reaction of fluorinated epoxy resin

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